scholarly journals The Role of Nonhuman Primate Animal Models in the Clinical Development of Pluripotent Stem Cell Therapies

2016 ◽  
Vol 24 (7) ◽  
pp. 1165-1169 ◽  
Author(s):  
So Gun Hong ◽  
Yongshun Lin ◽  
Cynthia E Dunbar ◽  
Jizhong Zou
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Nonhuman Primate ◽  
Pluripotent Stem Cell ◽  
Clinical Development ◽  
Stem Cell Therapies ◽  
Cell Therapies

Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies

2019 ◽  
Vol 14 (6) ◽  
pp. 454-459
Author(s):  
Xuejing Hou ◽  
Ying Liu ◽  
Isabelle Streuli ◽  
Patrick Dällenbach ◽  
Jean Dubuisson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Molecular Mechanisms ◽  
Uterine Cavity ◽  
Stem Cell Therapies ◽  
Intrauterine Adhesions ◽  
Asherman’S Syndrome ◽  
Cell Therapies ◽  
Fibrotic Process ◽  
Physical Barriers

Asherman’s Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman’s syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman’s Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.

scholarly journals Stem cell therapies for ischemic stroke: current animal models, clinical trials and biomaterials

RSC Advances ◽  
2017 ◽  
Vol 7 (30) ◽  
pp. 18668-18680 ◽  
Author(s):  
Hugh H. Chan ◽  
Connor A. Wathen ◽  
Ming Ni ◽  
Shuangmu Zhuo
Keyword(s):  
Tissue Engineering ◽  
Clinical Trials ◽  
Stem Cell ◽  
Ischemic Stroke ◽  
Animal Models ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Stem Cell Therapies ◽  
Cell Therapies

We report the facilitation of stem cell therapy in stroke by tissue engineering and applications of biomaterials.

scholarly journals Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Renata M. Martin ◽  
Jonas L. Fowler ◽  
M. Kyle Cromer ◽  
Benjamin J. Lesch ◽  
Ezequiel Ponce ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies

scholarly journals Endothelial-Mesenchymal Transition in Regenerative Medicine

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Damian Medici
Keyword(s):  
Stem Cell ◽  
Degenerative Diseases ◽  
Connective Tissues ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Mesenchymal Transition ◽  
Signaling Mechanisms ◽  
Recent Developments ◽  
Endothelial Mesenchymal Transition

Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration.

scholarly journals Large animal models for cardiac stem cell therapies

2011 ◽  
Vol 75 (8) ◽  
pp. 1416-1425 ◽  
Author(s):  
F. Gandolfi ◽  
A. Vanelli ◽  
G. Pennarossa ◽  
M. Rahaman ◽  
F. Acocella ◽  
...  
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Large Animal ◽  
Cardiac Stem Cell ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Large Animal Models
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