scholarly journals Involvement of Ovarian Estradiol Biosynthesis and Pituitary FSH Expression in the Mechanism of Human Chorionic Gonadotropin Stimulation of Uterine Growth in Immature Female Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sandrine Rafert ◽  
Julie Mariot ◽  
Danièle Klett ◽  
Yves Combarnous
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Plasma Concentrations ◽  
Female Rats ◽  
Aromatase Activity ◽  
Immature Female ◽  
Subunit Mrna ◽  
B Subunit ◽  
New Information ◽  
Uterine Growth

In a previous work, we showed that human Chorionic Gonadotropin (hCG) alone is able to stimulate uterine ponderal growth in immature female rats. In the present paper, we provide new information indicating that a single 100 ng hCG injection increased ovarian androgen availability and aromatase activity. These changes are consistent with an increase in ovarian estradiol secretion. Ovarian activin βA and activin βB subunit RNAs expression were also increased following hCG injection. Most interestingly, this treatment also led to an increase in FSHβ subunit mRNA expression in the pituitary, which might be due to hCG-stimulated ovarian activin secretion. We have not been able so far to follow the kinetics of the plasma concentrations of activin and FSH in hCG-treated animals compared to control animals. This has to be explored in the future to provide a more complete assessment of our model.

Administration of human chorionic gonadotropin affects sleep-wake phases and other associated behaviors in cycling female rats

1994 ◽  
Vol 654 (2) ◽  
pp. 181-190 ◽  
Author(s):  
P. Toth ◽  
H. Lukacs ◽  
E.S. Hiatt ◽  
K.H. Reid ◽  
V. Iyer ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Female Rats

scholarly journals The effects of estradiol and human chorionic gonadotropin on ACHT cells in peripubertal female rats: A histological and stereological study

2014 ◽  
Vol 66 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Verica Milosevic ◽  
Danijela Todorovic ◽  
Branka Sosic-Jurjevic ◽  
Ivana Medigovic ◽  
Jasmina Pantelic ◽  
...  
Keyword(s):  
Body Weight ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Volume Density ◽  
Female Rats ◽  
Stereological Analysis

The effects of estradiol (EDP) and human chorionic gonadotropin (HCG) on histological and stereological features of adrenocorticotropic (ACTH) cells in peripubertal female rats were examined. The first group of females received five injections of EDP (0.25 mg/kg b.w.), every second day from the 4th to 14th day after birth, and was killed at the peripubertal stage. The second group of females was given two injections of pregnyl-gonadotrophinum chorionicum (HCG; 50 IU/kg body weight) on the 36th and 37th days after birth, and it was killed 24 h after the last treatment. The controls were injected with an equivalent volume of the corresponding vehicle. ACTH cells were immunohistochemically labeled and stereologically evaluated. Stereological analysis showed that the volume of ACTH cells and their volume density in peripubertal females treated with EDP, were decreased by 15.6% and 53.8% (p<0.05), respectively, compared to the controls. In HCG-treated animals, the observed parameters were increased by 39.2% and 15.4% (p<0.05), respectively, in comparison with the control females. These findings suggest that the application of EDP or HCG exerted opposite effects on the stereological features of pituitary ACTH cells.

Ectopic production of the b-subunit of human chorionic gonadotropin by non-trophoblastic tumors and its clinical relevance

Placenta ◽  
1997 ◽  
Vol 18 (8) ◽  
pp. A2
Author(s):  
R. Nishimura ◽  
T. Koizumi ◽  
T. Yokotani ◽  
M. Yoshimura ◽  
T. Nakagawa ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Clinical Relevance ◽  
B Subunit ◽  
Trophoblastic Tumors ◽  
Ectopic Production

scholarly journals Cyp11b1 Is Induced in the Murine Gonad by Luteinizing Hormone/Human Chorionic Gonadotropin and Involved in the Production of 11-Ketotestosterone, a Major Fish Androgen: Conservation and Evolution of the Androgen Metabolic Pathway

Endocrinology ◽  
2007 ◽  
Vol 149 (4) ◽  
pp. 1786-1792 ◽  
Author(s):  
Takashi Yazawa ◽  
Miki Uesaka ◽  
Yoshihiko Inaoka ◽  
Tetsuya Mizutani ◽  
Toshio Sekiguchi ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Metabolic Pathway ◽  
Leydig Cells ◽  
Plasma Concentrations ◽  
Luciferase Reporter ◽  
Reporter System ◽  
Mouse Ovary ◽  
Luciferase Reporter System

We have shown previously that Cyp11b1, an 11β-hydroxylase responsible for glucocorticoid biosynthesis in the adrenal gland, was induced by cAMP in androgen-producing Leydig-like cells derived from mesenchymal stem cells. We found that Cyp11b1 was induced in male Leydig cells, or female theca cells, when human chorionic gonadotropin was administered in immature mice. Expression of Cyp11b1 in rodent gonads caused the production of 11-ketotestosterone (11-KT), a major fish androgen, which induces male differentiation or spermatogenesis in fish. As in teleosts, plasma concentrations of 11-KT were elevated in human chorionic gonadotropin-treated mice. In contrast to teleosts, however, plasma concentrations of 11-KT were similar in both sexes, despite levels of testosterone, a precursor substrate, being about 20 times higher in male mice. Because expression of 11β-hydroxysteroid dehydrogenase type 2, was much higher in the mouse ovary than in the testis, conversion of testosterone into 11-KT may occur more efficiently in the ovary. In a luciferase reporter system that was responsive to and activated by androgens, 11-KT efficiently activated mammalian androgen receptor-mediated transactivation. Our results suggest that the androgen metabolic pathway is conserved between teleosts and mammals, despite sexual dominance and reproductive functions of 11-KT being altered during evolution.

ABSENCE OF THE COOH-TERMINAL PEPTIDE ON ECTOPIC HUMAN CHORIONIC GONADOTROPIN B-SUBUNIT (hCGB)

Endocrinology ◽  
1982 ◽  
Vol 110 (6) ◽  
pp. 2198-2200 ◽  
Author(s):  
LAURENCE A. COLE ◽  
STEVEN BIRKEN ◽  
SUSSAN SUTPHEN ◽  
ROBERT O. HUSSA ◽  
ROLAND A. PATTILLO
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
B Subunit

scholarly journals Evaluation of Human Chorionic Gonadotropin β-Subunit mRNA Concentrations in Maternal Serum in Aneuploid Pregnancies: A Feasibility Study

2004 ◽  
Vol 50 (6) ◽  
pp. 1055-1057 ◽  
Author(s):  
Enders K O Ng ◽  
Ahmad El-Sheikhah ◽  
Rossa W K Chiu ◽  
K C Allen Chan ◽  
Matthew Hogg ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Maternal Serum ◽  
Β Subunit ◽  
Subunit Mrna
Sign in / Sign up

Export Citation Format

Share Document