scholarly journals Effects of regulating gut microbiota on the serotonin metabolism in the chronic unpredictable mild stress rat model

2019 ◽  
Vol 31 (10) ◽  
Author(s):  
Huawei Li ◽  
Peng Wang ◽  
Luqiao Huang ◽  
Ping Li ◽  
Dianliang Zhang
Keyword(s):  
Gut Microbiota ◽  
Rat Model ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Serotonin Metabolism

A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25751-25765 ◽  
Author(s):  
Xinyu Yu ◽  
Shanlei Qiao ◽  
Di Wang ◽  
Jiayong Dai ◽  
Jun Wang ◽  
...  
Keyword(s):  
Animal Model ◽  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Depressive Disorder ◽  
Rat Model ◽  
Untargeted Metabolomics ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Major Depressive ◽  
Metabolomics Study

An untargeted metabolomics study to investigate the metabolome change in plasma, hippocampus and prefrontal cortex (PFC) in an animal model with a major depressive disorder (MDD) had been conducted.

Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress

2014 ◽  
Vol 152 (1) ◽  
pp. 217-226 ◽  
Author(s):  
Guang Yue Su ◽  
Jing Yu Yang ◽  
Fang Wang ◽  
Jie Ma ◽  
Kuo Zhang ◽  
...  
Keyword(s):  
Rat Model ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress

scholarly journals Integration of 1H NMR and UPLC-Q-TOF/MS for a Comprehensive Urinary Metabonomics Study on a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63624 ◽  
Author(s):  
Hong-mei Jia ◽  
Yu-fei Feng ◽  
Yue-tao Liu ◽  
Xing Chang ◽  
Lin Chen ◽  
...  
Keyword(s):  
1H Nmr ◽  
Rat Model ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Tof Ms

scholarly journals Effect of Electroacupuncture on Reuptake of Serotonin via miRNA-16 Expression in a Rat Model of Depression

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Jun Zhao ◽  
Huiling Tian ◽  
Hongtao Song ◽  
Xu Wang ◽  
Tong Luo ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Rat Model ◽  
Exploratory Behavior ◽  
Continuous Wave ◽  
Behavioral Changes ◽  
Sucrose Preference ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Antidepressant Effects

The current study aimed to investigate the effects and mechanisms of electroacupuncture (EA) treatment applied to Bai hui (GV20) and Yin tang (GV29) acupoints (1 mA, 2 Hz, continuous wave, 20 minutes) for 28 days in a rat model of chronic unpredictable mild stress (CUMS) on reuptake of serotonin (5-hydroxytryptamine (5-HT)) and miRNA-16 levels in the hippocampus and serum. Rats were housed in individual cages, and CUMS was used to establish a rat model of depression. After EA treatment for 4 weeks, behavioral changes and indices including 5-HT transporter (SERT), 5-HT, and miRNA-16 levels in the hippocampus and serum were examined. The EA treatment significantly improved base levels of sucrose preference and exploratory behavior and significantly decreased SERT protein and mRNA expression in the hippocampus of depressed rats. Significantly increased 5-HT levels were observed, and miRNA-16 levels were significantly decreased in the hippocampus and serum of depressed rats. In conclusion, the antidepressant effects of EA treatment may be affected via inhibition of 5-HT reuptake, upregulation of 5-HT levels, and inhibition of miRNA-16 expression in the hippocampus and serum.

Impact of traditional Chinese medicine treatment on chronic unpredictable mild stress-induced depression-like behaviors: intestinal microbiota and gut microbiome function

2019 ◽  
Vol 10 (9) ◽  
pp. 5886-5897 ◽  
Author(s):  
Wan Qu ◽  
Shuo Liu ◽  
Weijie Zhang ◽  
Huawei Zhu ◽  
Qian Tao ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Gut Microbiota ◽  
Noncommunicable Diseases ◽  
Mild Stress ◽  
Chronic Unpredictable Mild Stress ◽  
Brain Health ◽  
Health Disorders ◽  
Chinese Medicine Treatment ◽  
Gut Microbiota Dysbiosis

Gut microbiota dysbiosis is a recognized contributing factor to many noncommunicable diseases, but more evidence is still needed to illustrate its causative impact on mental and brain health disorders and mechanism(s) for targeted mitigation.

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