scholarly journals Metastatic Malignant Ovarian Steroid Cell Tumor: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Jessica Lee ◽  
Veena S. John ◽  
Sharon X. Liang ◽  
Catherine A. D’Agostino ◽  
Andrew W. Menzin
Keyword(s):  
Case Report ◽  
Residual Disease ◽  
Tumor Resection ◽  
Cell Tumor ◽  
Clinicopathological Features ◽  
Review Of The Literature ◽  
Ovarian Steroid ◽  
Total Hysterectomy ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

We report a case of malignant ovarian steroid cell tumor not otherwise specified (NOS) in a 47-year-old female who presented with hirsutism, virilization, and amenorrhea. At the time of laparotomy, the tumor had already spread to the pelvic cul-de-sac. She underwent a total hysterectomy, bilateral salpingo-oophorectomy, and tumor resection with no residual disease. She received three cycles of bleomycin, etoposide, and cisplatin (BEP) and is now free of disease 24 months after surgery. Literature review of ovarian steroid cell tumors NOS including clinicopathological features and clinical management was performed.

scholarly journals A large ovarian steroid cell tumor‐not otherwise specified with a unique combination of benign and malignant features as a challenging cause of oligomenorrhea and hirsutism in a 21‐year‐old Syrian female: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Munawar Hraib ◽  
Rana Issa ◽  
Thanaa Alassi ◽  
Zuheir Alshehabi
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Virgin Female ◽  
Cell Tumor ◽  
Diagnostic Methods ◽  
Unique Combination ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
Rare Category

Abstract Background Ovarian steroid cell tumors represent a rare category of sex cord-stromal tumors that constitute less than 0.1% of all ovarian tumors. These neoplasms are classified into three main subtypes according to the cell of origin: Leidyg cell tumors, stromal luteomas, and steroid cell tumors not otherwise specified (SCTs-NOS). The latter subtype is defined as a neoplasm of an uncertain lineage that mostly affects middle-aged women, whereas it’s rare in younger ages. Case presentation We report a case of a 21-year-old virgin female who presented to our hospital with complaints of mild abdominal pain, hirsutism, and oligomenorrhea for more than a year. Before her current admission, the patient had attended an external gynecologic clinic where she had been prescribed oral contraceptives to regulate her periods. Nevertheless, on presentation to our institution, physical examination revealed abdominal tenderness with a palpable pelvic mass and mild hirsutism in the thigh. Ultrasonography demonstrated a large left ovarian mass measuring 154 × 104 mm, and compressing the uterus. Therefore, a unilateral salpingo-oophorectomy was performed, and interestingly, pathologic examination of the large aforementioned mass alongside with immunohistochemical correlation revealed the diagnosis of a large ovarian steroid cell tumor-not otherwise specified with a unique combination of benign and malignant features. Conclusions Although ovarian steroid cell tumors represent a rare category, they must be considered in the differential diagnosis for mild virilization symptoms in young females due to the importance of early diagnosis and management. In this manuscript, we aimed to present the first case report from Syria that highlights the crucial role of detailed morphological examination for challenging cases despite the difficulties in differential diagnosis, and the absence of ancillary techniques. Furthermore, we managed to discuss a brief review of diagnostic methods, histological characteristics, and treatment recommendations.

scholarly journals MALIGNANT OVARIAN STEROID CELL TUMOR CAUSING SEVERE HYPERANDROGENISM: CASE REPORT AND REVIEW OF THE LITERATURE

2017 ◽  
Vol 3 (3) ◽  
pp. e269-e274
Author(s):  
Omalkhaire M. Alshaikh ◽  
Stephane Laframboise ◽  
Sylvia L. Asa ◽  
Blaise Clarke ◽  
Ozgur Mete ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Tumor ◽  
Review Of The Literature ◽  
Ovarian Steroid ◽  
Steroid Cell Tumor

scholarly journals Ovarian steroid cell tumor, not otherwise specified: A case report and literature review

2016 ◽  
Vol 5 (6) ◽  
pp. 839-841 ◽  
Author(s):  
Lili Qian ◽  
Zhen Shen ◽  
Xuefen Zhang ◽  
Dabao Wu ◽  
Ying Zhou
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

scholarly journals Malignant Ovarian Steroid Cell Tumor, Not Otherwise Specified, Causes Virilization in a 4-Year-Old Girl: A Case Report and Literature Review

2020 ◽  
Vol 13 (1) ◽  
pp. 358-364
Author(s):  
Takaharu Yoshimatsu ◽  
Kozo Nagai ◽  
Reiji Miyawaki ◽  
Kyoko Moritani ◽  
Kazuhiro Ohkubo ◽  
...  
Keyword(s):  
Replacement Therapy ◽  
Tumor Resection ◽  
Serum Levels ◽  
Cell Tumor ◽  
Pathological Examination ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
The Right ◽  
Tomography Scan

We report a case of a 4-year-old girl with an ovarian steroid cell tumor, not otherwise specified (SCT-NOS). She was admitted to the hospital with progressing virilization and Cushing’s syndrome, which included abnormality of the perineum, hirsutism, hypertrichosis, flushing of face, hoarseness, and weight gain. Blood testing showed a significantly increased testosterone level and slightly increased cortisol level. Computed tomography scan revealed an 8.0 × 5.0 × 5.0 cm tumor of the right ovary. The patient underwent right salpingo-oophorectomy, and pathological examination showed malignant potential. Three courses of bleomycin, etoposide, and cisplatin were administered as postoperative chemotherapy. After tumor resection, her testosterone decreased to undetectable levels. However, during the course of the treatment, the patient suffered from adrenal insufficiency resulting in the need for hydrocortisone replacement therapy. Although SCT-NOS in childhood are typically benign, pathological findings should be carefully observed for potential malignancy. In cases of cortisol-producing SCT-NOS, serum levels should be monitored, and hydrocortisone replacement therapy should be considered before resection.

Ovarian steroid cell tumor, not otherwise specified: A clinicopathological and immunohistochemical experience of 12 cases

2014 ◽  
Vol 41 (3) ◽  
pp. 424-431 ◽  
Author(s):  
Saroona Haroon ◽  
Romana Idrees ◽  
Saira Fatima ◽  
Aisha Memon ◽  
Naila Kayani
Keyword(s):  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

scholarly journals An asymptomatic ovarian steroid cell tumor with complete cystic morphology: A case report

2013 ◽  
Vol 56 (1) ◽  
pp. 50 ◽  
Author(s):  
Yoon Jung Chun ◽  
Hyun Jung Choi ◽  
Han Na Lee ◽  
Sook Cho ◽  
Ji Hyang Choi
Keyword(s):  
Case Report ◽  
Cell Tumor ◽  
Ovarian Steroid ◽  
Steroid Cell Tumor
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