Ovarian steroid cell tumor, not otherwise specified: A clinicopathological and immunohistochemical experience of 12 cases

2014 ◽  
Vol 41 (3) ◽  
pp. 424-431 ◽  
Author(s):  
Saroona Haroon ◽  
Romana Idrees ◽  
Saira Fatima ◽  
Aisha Memon ◽  
Naila Kayani
Keyword(s):  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

scholarly journals A large ovarian steroid cell tumor‐not otherwise specified with a unique combination of benign and malignant features as a challenging cause of oligomenorrhea and hirsutism in a 21‐year‐old Syrian female: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sawsan Ismail ◽  
Munawar Hraib ◽  
Rana Issa ◽  
Thanaa Alassi ◽  
Zuheir Alshehabi
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Virgin Female ◽  
Cell Tumor ◽  
Diagnostic Methods ◽  
Unique Combination ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
Rare Category

Abstract Background Ovarian steroid cell tumors represent a rare category of sex cord-stromal tumors that constitute less than 0.1% of all ovarian tumors. These neoplasms are classified into three main subtypes according to the cell of origin: Leidyg cell tumors, stromal luteomas, and steroid cell tumors not otherwise specified (SCTs-NOS). The latter subtype is defined as a neoplasm of an uncertain lineage that mostly affects middle-aged women, whereas it’s rare in younger ages. Case presentation We report a case of a 21-year-old virgin female who presented to our hospital with complaints of mild abdominal pain, hirsutism, and oligomenorrhea for more than a year. Before her current admission, the patient had attended an external gynecologic clinic where she had been prescribed oral contraceptives to regulate her periods. Nevertheless, on presentation to our institution, physical examination revealed abdominal tenderness with a palpable pelvic mass and mild hirsutism in the thigh. Ultrasonography demonstrated a large left ovarian mass measuring 154 × 104 mm, and compressing the uterus. Therefore, a unilateral salpingo-oophorectomy was performed, and interestingly, pathologic examination of the large aforementioned mass alongside with immunohistochemical correlation revealed the diagnosis of a large ovarian steroid cell tumor-not otherwise specified with a unique combination of benign and malignant features. Conclusions Although ovarian steroid cell tumors represent a rare category, they must be considered in the differential diagnosis for mild virilization symptoms in young females due to the importance of early diagnosis and management. In this manuscript, we aimed to present the first case report from Syria that highlights the crucial role of detailed morphological examination for challenging cases despite the difficulties in differential diagnosis, and the absence of ancillary techniques. Furthermore, we managed to discuss a brief review of diagnostic methods, histological characteristics, and treatment recommendations.

Ovarian steroid cell tumor not otherwise specified with virilizing manifestations: clinical case

2014 ◽  
Author(s):  
Raquel Espirito-Santo ◽  
Teresa Sabino ◽  
Tania Almeida ◽  
Antonio Figueiredo ◽  
Ana Pena ◽  
...  
Keyword(s):  
Clinical Case ◽  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

Ovarian steroid cell tumor, not otherwise specified, producing testosterone

2014 ◽  
Vol 40 (9) ◽  
pp. 2081-2085 ◽  
Author(s):  
Mika Mizoguchi ◽  
Sawako Minami ◽  
Madoka Yamamoto ◽  
Yuko Tanizaki ◽  
Aya Kobayashi ◽  
...  
Keyword(s):  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

scholarly journals MON-004 Ovarian Steroid Cell Tumor, Not Otherwise Specified (NOS): A Case Report and Clinical Review

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Miry Lobaton ◽  
Luz M Malanco ◽  
Liliana Trejo
Keyword(s):  
Multidisciplinary Team ◽  
Transvaginal Ultrasound ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Total Testosterone ◽  
Ovarian Steroid ◽  
Endocrine Activity ◽  
Not Otherwise Specified ◽  
Imaging Results ◽  
Steroid Cell Tumor

Abstract Background: Ovarian tumors are divided into non functioning and functioning, within the last group, we can find those with endocrine activity that produce androgenization. Ovarian cell tumors, not otherwise specified (SCT-NOS) is a rare type of ovarian sex cordomal tumor and represents the 60% of this tumors, which compromise less than 0.1% of the ovarian tumors. (1) Clinical Case: We here present a 28 year old woman who was referred to the Endocrine Clinic due to secondary amenorrhea and virilization signs. At the age of twelve a diagnosis of polycystic ovarian syndrome (POS) was made and treated with combined oral anticonceptive (COA). Menses became regular only with medication. Six months after she stopped medication, amenorrhea and virilization signs worsened. Biochemically she had levels of serum total testosterone 6.8 ng/mL (0.02-0.45) and free testosterone 42 pg/mL (0.1-6.4) since only pelvic ultrasonography has been made by physician, a transvaginal ultrasound and abdomen – pelvic CT scan showed a anexial tumor. After analysis of biochemical and imaging results a multidisciplinary team performed a surgical extirpation of the primary lesion, which was diagnosed by histopathology as a tumor of lipoidic cells NOS. A month after the surgery, menses became regular. Conclusion: The purpose of this article is to present the available information about this kind of tumors and the treatment recommended. It is mandatory to follow a correct approach among a multidisciplinary team, in order to get the correct diagnosis at the proper time. (1) Zang L, Ye M, Yang G, Li J, Liu M, Du J et al. Accessory ovarian steroid cell tumor producing testosterone and cortisol. Medicine. 2017;96(37):e7998.

Hypothyroidism and hyperlipidemia with a virilizing ovarian steroid cell tumor, not otherwise specified

2007 ◽  
Vol 23 (2) ◽  
pp. 69-71 ◽  
Author(s):  
Horng-Jyh Tsai ◽  
Shu-Chen Chen ◽  
Hsiao-Yun Wei ◽  
Gin-Den Chen
Keyword(s):  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

scholarly journals Ovarian steroid cell tumor, not otherwise specified: A case report and literature review

2016 ◽  
Vol 5 (6) ◽  
pp. 839-841 ◽  
Author(s):  
Lili Qian ◽  
Zhen Shen ◽  
Xuefen Zhang ◽  
Dabao Wu ◽  
Ying Zhou
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cell Tumor ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor

scholarly journals Androgen Secreting Steroid Cell Tumor of the Ovary Represented with Postmenopasal Bleeding and Extensive Hirsutism

2013 ◽  
Vol 1 (1) ◽  
pp. 93-98
Author(s):  
Jadranka Georgievska ◽  
Vesna Antovska ◽  
Neli Basheska ◽  
Natasha Aleksioska
Keyword(s):  
Elevated Serum ◽  
Serum Testosterone ◽  
Cell Tumor ◽  
Postmenopausal Bleeding ◽  
Normal Range ◽  
Ovarian Steroid ◽  
Not Otherwise Specified ◽  
Steroid Cell Tumor ◽  
History Of

Introduction: Steroid cell tumors of the ovary present less than 0.1% of all ovarian tumors and belong in the group of sex cord-stromal tumors.Case description: We present a case of 69-year-old woman investigated because of postmenopausal bleeding, a 5-year history of excessive hirsutism, baldness and acne. The evaluation revealed elevated serum testosterone, but ultrasound detected a 2 cm-mass of the left ovary. The patient underwent hysterectomy and bilateral adnexectomy. The histopathology diagnosis was steroid cell tumor, not otherwise specified. Postoperative chemotherapy was administered at the discretion of the radio-oncologist. At the last follow-up 48 months after surgery, the hirsutism was completely resolved, the serum testosterone was within the normal range and there was no evidence of recurrence.Conclusion: In adult patients with hirsutism and elevated serum testosterone a possibility of a presence of an ovarian steroid cell tumor should be considered. Surgery is the main treatment of such patients.

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