scholarly journals Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Henghui Cheng ◽  
Shouhua Yang ◽  
Zhiling Qu ◽  
Sheng Zhou ◽  
Qiurong Ruan
Keyword(s):  
Breast Carcinoma ◽  
Breast Tissue ◽  
Invasive Carcinoma ◽  
Malignant Tumors ◽  
Myoepithelial Cells ◽  
Invasive Breast Carcinoma ◽  
Breast Lesions ◽  
Human Breast ◽  
Stromal Tumors ◽  
Muscle Myosin

Aims. DOG1 has proven to be a useful marker of gastrointestinal stromal tumors (GISTs). Recently, DOG1 expression has also been reported in some non-GIST malignant tumors, but the details related to DOG1 expression in breast tissue remain unclear. The aim of this study was to detect the expression of DOG1 in the human breast and to evaluate the feasibility of using DOG1 to discriminate between invasive breast carcinoma and noninvasive breast lesions.Methods and Results. A total of 210 cases, including both invasive and noninvasive breast lesions, were collected to assess DOG1 expression immunohistochemically. DOG1 expression was consistently positive in breast myoepithelial cells (MECs), which was similar to the results obtained for three other MEC markers: calponin, smooth muscle myosin heavy chain (SMMHC), and P63 (P>0.05in all). Importantly, DOG1 was useful in discriminating invasive breast carcinoma from noninvasive breast lesions (P<0.05).Conclusions. DOG1 is a useful marker of breast MECs, and adding DOG1 to the MEC identification panel will provide more sophisticated information when diagnosing uncertain cases in the breast.

Tubulopapillary Carcinoma: An Aggressive Variant of Invasive Breast Carcinoma With a Micropapillary DCIS-Like Morphology

2019 ◽  
Vol 28 (5) ◽  
pp. 536-540
Author(s):  
Claudio Guerrieri ◽  
Rachel Hudacko
Keyword(s):  
Breast Carcinoma ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Myoepithelial Cells ◽  
Invasive Breast Carcinoma ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Invasive Micropapillary Carcinoma ◽  
Serous Papillary Carcinoma

Tubulopapillary carcinoma is a recently described variant of breast carcinoma characterized by a proliferation of elongated and anastomosing tubular glands exhibiting intraluminal micropapillary and sometimes papillary epithelial projections. We have recently encountered a patient with invasive breast carcinoma displaying a prominent tubulopapillary component. The histomorphology in our case had an uncanny resemblance to micropapillary ductal carcinoma in situ, but the invasive nature of the glands was confirmed not only by the lack of myoepithelial cells but also by the presence of identical metastatic foci within ipsilateral axillary lymph nodes. This case was made all the more intricate by the simultaneous presence of invasive micropapillary carcinoma in the opposite breast and a carcinosarcoma of the uterus with a serous papillary carcinoma component. As noted in the only prior report on tubulopapillary carcinoma of the breast, our case confirms the aggressive nature of this form of invasive carcinoma, the histological features of which appear to be easily identifiable and reproducible.

scholarly journals Invasive Carcinoma Mammae dengan Metastasis Orbita, Tulang, dan Paru

2019 ◽  
Vol 8 (1S) ◽  
pp. 89
Author(s):  
Putri Avryna ◽  
Irza Wahid ◽  
Fauzar Fauzar
Keyword(s):  
Breast Carcinoma ◽  
Invasive Ductal Carcinoma ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Invasive Breast Carcinoma ◽  
Not Otherwise Specified ◽  
Grade Ii ◽  
Carboplatin Auc

Carcinoma mammae (kanker payudara) merupakan penyakit keganasan yang paling banyak terjadi pada wanita di negara berkembang dan merupakan penyebab kematian wanita kedua di Amerika Serikat.Pada tahun 2014, terdapat 232.000 kasus baru pada wanita di Amerika Serikat dan dengan angka kematian 40.000 jiwa. Invasive breast carcinoma paling banyak berasal dari epitel duktus dan lebih dari 75% merupakan invasive ductal carcinoma not otherwise specified (IDC-NOS). Angka kejadian metastasis orbita 2-9% dari semua kasus keganasan pada dewasa dan 8-10% berasal dari kanker payudara. Pada kasus ini, wanita 36 tahun datang dengan keluhan sesak napas dan terdapat benjolan pada mata kiri sejak 2 bulan yang lalu. Pasien telah dikenal menderita Ca Mammae dengan hasil biopsy jaringan ditemukan invasive carcinoma mammae of no special type (NST) Grade II sejak 1,5 tahun sebelumnya, namun menolak pengobatan dan kemoterapi. Saat ini telah terjadi metastasis di orbita, metastasis tulang dan paru. Pasien diberikan kemoterapi dengan regimen Carboplatin (AUC 6) dan Paclitaxel 170 mg/m2 dan mengalami perbaikan secara signifikan.

Immunohistochemical demonstration of metallothionein in normal human breast tissue and benign and malignant breast lesions

1994 ◽  
Vol 30 (3) ◽  
pp. 213-221 ◽  
Author(s):  
Bert Bier ◽  
Anthony Douglas-Jones ◽  
Martin T�tsch ◽  
Barbara Dockhorn-Dworniczak ◽  
Werner B�cker ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Breast Lesions ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Immunohistochemical Demonstration ◽  
Normal Human Breast ◽  
Malignant Breast ◽  
Normal Human
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