scholarly journals Biochemical Markers of Bone Turnover in Patients withβ-Thalassemia Major: A Single Center Study from Southern Pakistan

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Sadia Sultan ◽  
Syed Mohammed Irfan ◽  
Syed Ijlal Ahmed
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
Biochemical Markers ◽  
Demographic Data ◽  
Thalassemia Major ◽  
Cross Sectional ◽  
Children And Adolescent ◽  
Markers Of Bone Turnover ◽  
25 Oh Vitamin D

Objectives. Skeletal complications inβ-homozygous thalassemic patients are uncommon but often debilitating, even amongst children and adolescent patients with well maintained transfusion and chelation therapy. The aim is to evaluate the biochemical markers of bone turnover in regularly transfused thalassemic patients and its possible correlations with demographic data and hematological and biochemical markers.Methods. In this prospective cross-sectional study, 36β-thalassemia major patients were enrolled from March 2012 to March 2014. All patients underwent complete blood counts, LFTs, serum ferritin, serum calcium, phosphorus, serum albumin, alkaline phosphatase, 25-OH vitamin D, and parathormone (PTH) levels.Results. There were 17 males and 19 females with mean age of 12.56 ± 5.9 years. Hypocalcemia and hypophosphatemia were seen in 66.6% and 19.4%, respectively, while 25-OH vitamin D deficiency was present in 72.2% of thalassemic children and adolescents. Hypoparathyroidism was seen in 13.8% while hyperparathyroidism was detected in 8.3% of patients. There was direct correlation between serum phosphorus and ferritin levels (P<0.05). No correlation was found between indirect bilirubin and skeletal parameters, calcium and parathyroid hormone (P>0.05).Conclusions. Biochemical profile is significantly altered in patients withβ-thalassemia major and bone associated biochemical abnormalities like hypocalcaemia, 25-OH vitamin D deficiency, and hypophosphatemia are not uncommon in Pakistani patients with thalassemia major.

scholarly journals Vitamin D Status of Epileptic Children in India: A Prospective Cross-Sectional Study from a Tertiary Care Centre

2020 ◽  
Vol 10 (01) ◽  
pp. e87-e92
Author(s):  
Chandrika Azad ◽  
Vishal Guglani ◽  
Jasbinder Kaur ◽  
Roosy Aulakh ◽  
Sukhvinder Singh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Epileptic Children ◽  
25 Oh Vitamin D

AbstractVitamin D deficiency is prevalent all over the world, especially in tropical countries. In epileptics, antiepileptic drugs (AED) and associated comorbidities further impact vitamin D status. The aim of this study is to estimate the prevalence of 25(OH) vitamin D deficiency in epileptic children and evaluate probable risk factors. A cross-sectional study of 200 children between 1 and 18 years of age on AED was undertaken in the pediatric neurology clinic of a tertiary care center of Northern India. In all children, serum 25(OH) vitamin D levels, calcium, phosphorus, and alkaline phosphatase were estimated. The deficiency levels of vitamin D were categorized as: deficiency <20 ng/mL, insufficiency 20 to 30 ng/mL, and sufficiency >30 ng/mL. The potential risk factors for hypovitaminosis D, including type of epilepsy, AED regimen (specific medications, polytherapy vs. monotherapy), cerebral palsy, ambulatory status, intellectual disability, body mass index, gender, and vegetarianism were examined. Among the 200 enrolled children (60% boys), 106/200 (53%) were vitamin D deficient. There was no significant relation of vitamin D levels with gender, type of epilepsy, neurological deficit, and type of AED. An inverse relationship of higher phenytoin doses during monotherapy associated with lower vitamin D levels in monotherapy was found, thereby suggesting adverse effect of high doses of phenytoin on vitamin D levels. VDD is common among epileptic children on AED therapy. Vitamin D deficiency is common prevalent among epileptic children on AED therapy, and its detection and treatment correction should be an integral part of epilepsy management.

scholarly journals Vitamin D deficiency in children with bronchial asthma in southern Jordan: a cross-sectional study

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052097424
Author(s):  
Enas Al-Zayadneh ◽  
Nedal Awad Alnawaiseh ◽  
Salma Ajarmeh ◽  
Areej Hamed Altarawneh ◽  
Eman M Albataineh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bronchial Asthma ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Objectives To assess serum 25-hydroxycholecalciferol (25-OH vitamin D) levels in Jordanian children with bronchial asthma, and to examine correlations between 25-OH vitamin D levels and asthma severity and control. Methods A cross-sectional study was conducted at the Paediatric Chest Clinic, Al-Karak Governmental Hospital, Southern Jordan, between May 2015 and February 2016. Serum 25-hydroxyvitamin D level was determined in children aged 1–14 years diagnosed with bronchial asthma (6–14 years) or recurrent wheezing episodes (<6 years). Asthma severity was determined based on the Global Initiative for Asthma assessment, the Asthma Control Test, and the Childhood Asthma Control Test. Demographic and clinical characteristics were compared between patients with low and normal 25-OH vitamin D levels, and correlations between asthma severity and 25-OH vitamin D level were assessed. Results Out of 98 included children, 25-OH vitamin D levels were deficient and insufficient in 41 (41.8%) and 34 (34.7%) children, respectively. Only 23 (23.5%) had sufficient 25-OH vitamin D levels. A significant correlation was found between severity of asthma symptoms and 25-OH vitamin D deficiency. Conclusion 25-OH vitamin D deficiency is highly prevalent in Jordanian children with bronchial asthma and correlates significantly with asthma severity.

scholarly journals Vitamin D deficiency associations with metabolic, bone turnover and adverse general health markers in community free living adults

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Salah Gariballa ◽  
Javed Yasin ◽  
Ghada Abluwi ◽  
Awad Al Essa
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
United Arab Emirates ◽  
Multiple Logistic Regression Analysis ◽  
Health Impact ◽  
Clinical Markers ◽  
Free Living ◽  
Cross Sectional ◽  
Older Subjects

Abstract Background Although there is some evidence that vitamin D deficiency is highly prevalent in the Middle East, however its health impact is still not clear. The aim of this study was to assess the prevalence, causes and health implications of vitamin D deficiency in local United Arab Emirates (UAE) citizens. Methods A cross-sectional study was conducted on community free living adults living in the city of Al Ain, UAE. Following informed written consent eligible subject’s blood and urine samples were taken for measurements of vitamin D [25(OH)D], metabolic and bone turnover markers. Clinical assessment that includes general and self-rated health, muscle health, and physical activity were also performed. Results A total of 648 subjects (491 female) were included in this analysis. Their mean (SD) age was 38 (12) years. Mean 25(OH)D was 24 ng/ml (range: 4–67) with 286 (44%) subjects found to have vitamin D deficiency (< 20 ng/ml), 234 (36%) subjects have insufficiency (20-32 ng/ml) and 128 (20%) subjects have optimal concentrations (> 32 ng/ml). 25(OH)D concentrations were significantly higher in local indigenous UAE subjects compared to other Arab expatriates (p = 0.071). Although there were no statistically significant differences in clinical markers between groups, however, utra-sensitive C-reactive protein (us-CRP), parathyroid hormone (PTH), body mass index (BMI) and the bone markers U-PYD and PYD/CR were higher in vitamin D deficient older subjects aged ≥50 years and female subjects younger than 50 years respectively compared to those with insufficiency or optimal concentrations (p value < 0.05. Multiple logistic regression analysis revealed significant and independent association between 25(OH)D status and age and sex (p < 0.05). Conclusion Older subjects with vitamin D deficiency have increased BMI, inflammation and PTH compared with those with insufficiency or optimal concentrations. Co-existence of obesity and vitamin D deficiency may have increased adverse health effects.

Association Of Vitamin D Deficiency And Pelvic Organ Prolapse In Postmenopausal Women: A Cross-Sectional Study

2021 ◽  
Author(s):  
Mateja Legan ◽  
Matija Barbič ◽  
Josko Osredkar ◽  
Mija Blaganje
Keyword(s):  
Vitamin D ◽  
Pelvic Organ Prolapse ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Test Group ◽  
Pelvic Organ ◽  
Cross Sectional ◽  
Vaginal Deliveries ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Abstract Background: Vitamin D is vital for skeletal integrity as well as optimal muscle work. High incidence and prevalence of vitamin D deficiency as well as pelvic organe prolapse are found in postmenopausal women, thus raising the question of whether the entities could be related.Methods: We compared 50 postmenopausal women with pelvic organ prolapse (POP) with 48 age- and weight-matched controls. The clinical assessment of the disorder was performed using the Pelvic Organ Prolapse Quantification system (POP-Q). A questionnaire was filled out by the participants and a blood sample was collected for 25-OH-vitamin D determination.Results: The two groups did not differ significantly in body mass index, but differed significantly in vitamin D blood level concentrations, those being lower in POP patients. A significantly higher prevalence of vitamin D deficiency (25-OH-vitamin D< 50 nmol/l) was found in the test group compared to controls. Higher parity/vaginal deliveries and less caesarean sections were found in patients than in controls. Conclusions: Vitamin D deficiency might be an important associated systemic factor associated to pelvic organ prolapse. The determination of vitamin D levels in postmenopausal women and replenishing its deficiency might also be of importance for the pelvic floor.

Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy

2008 ◽  
Vol 167 (12) ◽  
pp. 1369-1377 ◽  
Author(s):  
Sina Nettekoven ◽  
Alexander Ströhle ◽  
Birgit Trunz ◽  
Maike Wolters ◽  
Susanne Hoffmann ◽  
...  
Keyword(s):  
Vitamin D ◽  
Drug Therapy ◽  
Bone Turnover ◽  
Antiepileptic Drug ◽  
Biochemical Markers ◽  
Vitamin D Status ◽  
Markers Of Bone Turnover ◽  
Antiepileptic Drug Therapy

scholarly journals Is there an association between vitamin D and risk of stroke?: a North Indian study

2019 ◽  
Vol 7 (4) ◽  
pp. 1026
Author(s):  
Mahajan M. ◽  
Hilal A. Sheikh ◽  
Anand Ish ◽  
Batra A. ◽  
Sethi P. K.
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
North India ◽  
Care Hospital ◽  
Cross Sectional ◽  
Age And Gender ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
And Gender

Background: Vitamin D deficiency is present in India in epidemic proportions despite plenty of sunshine. Reduced plasma 25(OH) D concentrations as a diagnostic marker of vitamin D deficiency have been in past decade associated with several well-established risk factors for ischaemic stroke, such as arterial hypertension, thrombosis, atherosclerosis. The aims and objectives of this study was to compare the serum 25(OH) D levels between the first ever acute stroke patients and healthy controls.Methods: A cross-sectional, case control study was conducted in a tertiary care hospital in New Delhi situated in north India. Serum 25‑hydroxyvitamin D (25(OH) D) levels in 85 patients of ischemic stroke, presenting within 7 days of onset of stroke was measured and was compared with 70 age and gender matched controls.Results: The mean age was 61.02±11.58 years and 58.63±11.28 years in cases and controls respectively. Females constituted 37.6% of the total number of cases and 43.4% of the controls. The age and gender-distribution were comparable between the cases and controls. The median value (IQR) of serum 25(OH) vitamin D level was 7.94 ng/mL (4.59-14.00) in the cases and it was 8.82 ng/mL (5.59-14.70) in the controls. The difference between the serum 25(OH) vitamin D levels of the two groups was not found to be statistically significant.Conclusions: There is a high prevalence of biochemical hypo-vitaminosis D in apparently healthy Indians of all age and sex groups despite adequate sunshine. There is no association between low vitamin D levels and stroke.

scholarly journals Investigation of Vitamin D Deficiency in 
Pre-School Children During Summer Season

2021 ◽  
Vol 10 (1) ◽  
pp. 21-27
Author(s):  
Esra Ulgen Temel ◽  
Kenan Kocabay ◽  
Aybars Ozkan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Public Health Problem ◽  
Summer Season ◽  
Important Public Health Problem ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Aim: Vitamin D deficiency is an important public health problem, especially affecting children. The aim of our study is to evaluate the serum 25 (OH) vitamin D levels of children during the summer and to determine some features such as exposure to the sun, oral vitamin D supplementation, and to examine the parameters that affect serum vitamin D levels. Methods: In our study, children aged between 12 and 83 months were included. A questionnaire was answered by families. In this cross-sectional study, serum 25 (OH) vitamin D levels of children and biochemical parameters were examined. Results: The mean serum 25 (OH) vitamin D level was 27.0±12.4 ng/ml. Vitamin D deficiency was found 17%, and vitamin D insufficiency was 6%. The children that taking daycare indoors and body mass index <5th percentile had lower serum 25 (OH) vitamin D levels. Children between the ages of 12- 36 months and children with chronic diseases were found to have a shorter time to benefit from sunlight. Conclusion: The rate of vitamin D deficiency and insufficiency (<20 ng/ml) in children were found at 23% in summer season. Families and caregivers should be informed about vitamin D and should be aware of safe sun exposure. Keywords: Vitamin D, sunlight, summer, children, vitamin D deficiency

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