Biochemical markers of bone turnover, intact serum parathyroid hormone and renal calcium excretion in patients with pseudohypoparathyroidism and hypoparathyroidism before and during vitamin D treatment

1989 ◽  
Vol 148 (6) ◽  
pp. 535-539 ◽  
Author(s):  
K. Kruse ◽  
U. Kracht ◽  
K. Wohlfart ◽  
U. Kruse
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Calcium Excretion ◽  
Serum Parathyroid Hormone ◽  
Markers Of Bone Turnover ◽  
Renal Calcium Excretion

scholarly journals High Prevalence of Vitamin D Insufficiency in China: Relationship with the Levels of Parathyroid Hormone and Markers of Bone Turnover

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e47264 ◽  
Author(s):  
Han-Kui Lu ◽  
Zeng Zhang ◽  
Yao-Hua Ke ◽  
Jin-Wei He ◽  
Wen-Zhen Fu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Bone Turnover ◽  
Vitamin D Insufficiency ◽  
Markers Of Bone Turnover ◽  
High Prevalence

Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy

2008 ◽  
Vol 167 (12) ◽  
pp. 1369-1377 ◽  
Author(s):  
Sina Nettekoven ◽  
Alexander Ströhle ◽  
Birgit Trunz ◽  
Maike Wolters ◽  
Susanne Hoffmann ◽  
...  
Keyword(s):  
Vitamin D ◽  
Drug Therapy ◽  
Bone Turnover ◽  
Antiepileptic Drug ◽  
Biochemical Markers ◽  
Vitamin D Status ◽  
Markers Of Bone Turnover ◽  
Antiepileptic Drug Therapy

Changes in calciotrophic hormones and biochemical markers of bone turnover in normal human pregnancy

1994 ◽  
Vol 131 (4) ◽  
pp. 369-374 ◽  
Author(s):  
Stephen J Gallacher ◽  
William D Fraser ◽  
Owen J Owens ◽  
Frances J Dryburgh ◽  
Fraser C Logue ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Plasma Concentrations ◽  
First Trimester ◽  
Creatinine Ratio ◽  
Human Pregnancy ◽  
Markers Of Bone Turnover ◽  
Normal Human

Gallacher SJ, Fraser WD, Owens OJ, Dryburgh FJ, Logue FC, Jenkins A, Kennedy J, Boyle IT. Changes in calciotrophic hormones and biochemical markers of bone turnover in normal human pregnancy. Eur J Endocrinol 1994;131:369–74. ISSN 0804–4643 Plasma concentrations of parathyroid hormone-related protein (PTHrP), parathyroid hormone, alkaline phosphatase, osteocalcin and albumin-adjusted calcium were measured along with nephrogenous cyclic adenosine monophosphate (NcAMP) in 10 normal women longitudinally through pregnancy. In addition, an assessment of bone resorption was made in these same subjects by the measurement in true fasting urine specimens of the calcium/creatinine ratio (Ca/Cr), hydroxyproline/ creatinine ratio (HP/Cr), pyridinoline/creatinine ratio (Pyr/Cr) and deoxypyridinoline/creatinine ratio (Dpyr/Cr). The PTHrP level rose through pregnancy from (mean±sem) 0.8 ± 0.2 pmol/l in the first trimester to 2.7 ± 0.2 pmol/l 6 weeks postpartum (p < 0.0001). Serum alkaline phosphatase rose from 94 ± 8 U/l (first trimester) to 347 ± 25 U/l at term (p < 0.0001). A significant positive correlation was evident between PTHrP and alkaline phosphatase up to term (r = 0.44, p < 0.005). Parathyroid hormone concentrations remained unchanged during pregnancy but rose significantly postpartum from 1.8 ± 0.2 pmol/l (first trimester) to 3.1 ± 0.5 pmol/l (p < 0.0001). Similarly, osteocalcin, a marker of bone formative activity, remained unchanged through pregnancy but rose significantly at 6 weeks after delivery to 0.38 ± 0.05 nmol/l from 0.19 ± 0.03 nmol/l (first trimester) (p = 0.019). No significant change was noted in serum-adjusted calcium or NcAMP, either through pregnancy or at the postpartum assessment. Fasting urinary Ca/Cr fell through pregnancy from 0.70 ± 0.11 (first trimester) to a nadir of 0.19 ± 0.04 6 weeks postpartum (p = 0.007). Fasting urinary HP/Cr rose from 0.026 ± 0.003 (first trimester) to a peak of 0.049 ± 0.012 (third trimester), thereafter falling to 0.024 ± 0.002 6 weeks after delivery. Fasting urinary Pyr/Cr rose from 30.5 ± 1.7 (first trimester) to a peak of 58.3 ± 6.6 (term) (p = 0.009); Dpyr/Cr also increased through pregnancy from 9.9 ± 1.3 (first trimester) to 16.1 ± 1.7 (term) (p = 0.01). Previous studies have suggested that the placenta (during pregnancy) and breast milk (postpartum) are the main sources of PTHrP in pregnancy. This study illustrates that changes in plasma concentrations of PTHrP also can be demonstrated— although whether or not circulating PTHrP has a specific endocrine function is not clear. SJ Gallacher, University Department of Medicine, Queen Elizabeth Building, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK

scholarly journals Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women

2018 ◽  
Vol 56 (212) ◽  
pp. 754-758 ◽  
Author(s):  
Bikram Khadka ◽  
Mohan Lal Tiwari ◽  
Ravi Gautam ◽  
Binod Timalsina ◽  
Nandu Prasad Pathak ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Biochemical Markers ◽  
Inorganic Phosphorus ◽  
Menopausal Women ◽  
Markers Of Bone Turnover ◽  
Post Menopausal ◽  
Year Since Menopause

Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal.  Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20. Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01). Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.

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