scholarly journals Ocular Surface Disorders in a Group of Egyptian Children with End Stage Renal Failure on Dialysis: A Cross-Sectional Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Mohamed Anbar ◽  
Ahmed R. H. Ahmed ◽  
Abdel-Azeem M. El-Mazary ◽  
Ramadan A. Mahmoud
Keyword(s):  
Renal Failure ◽  
Dry Eye ◽  
Tear Film ◽  
Film Stability ◽  
End Stage Renal Failure ◽  
Tear Secretion ◽  
Tear Film Stability ◽  
Eye Symptoms ◽  
End Stage ◽  
Dry Eye Symptoms

Purpose. To investigate tear function, ocular manifestations, and squamous metaplasia of the conjunctival epithelium (SMCE) in children with end stage renal failure (ESRF) on dialysis.Methods. Thirty children with ESRF and 20 age and sex matched controls during the period from January 2014 to May 2015 underwent full ophthalmologic examination and the tear function was investigated by the Schirmer and tear film break-up time (TBUT) tests. SMCE was evaluated by impression cytology and immunocytochemistry. The correlations of tear function status with ESRF-related clinical and biochemical variables were measured statistically.Results. Dry eye symptoms were detected in 26% of children with ESRF, compared with none of the controls (P=0.05) and SMCE was almost absent. Values of the Schirmer and TBUT tests were significantly lower in children with ESRF for right eye (t=24.63,P=0.01, andt=11.9,P=0.002, resp.) and left eye (t=24.7,P=0.02, andt=11.4,P=0.0004, resp.). TBUT and the Schirmer test values were correlated inversely with the duration of ESRF (R=-0.45,P=0.01, andR=-0.46,P=0.01, resp.) and with the duration of dialysis (R=-0.39,P=0.03, andR=-0.45,P=0.01, resp.). None of the following parameters was associated with distorted tear function including serum creatinine, electrolytes, parathyroid hormone, total protein, albumin, CBC parameters, and systolic or diastolic blood pressure.Conclusion. The basal tear secretion and tear film stability were lower while the dry eye symptoms such as itching and redness were more common among children with ESRF. The duration of ESRF and dialysis duration seem to be related to the disturbances in tear secretion and tear film stability. However, SMCE is very rare.

Associations between dry eye symptoms with tear film stability, volume, and osmolarity in a sample of young adults in Kuala Lumpur

2018 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Bariah Mohd-Ali ◽  
MohamadHanif Hajar-Maidin ◽  
Asmah Ahmad ◽  
Zainora Mohammed ◽  
Jamaluddin Mohamed
Keyword(s):  
Young Adults ◽  
Dry Eye ◽  
Tear Film ◽  
Kuala Lumpur ◽  
Film Stability ◽  
Tear Film Stability ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

scholarly journals Effects of aerobic exercise on tear secretion and tear film stability in dry eye patients

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Chao Sun ◽  
Xiaofan Chen ◽  
Yanming Huang ◽  
Huan Zou ◽  
Wei Fan ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Dry Eye ◽  
Tear Film ◽  
Oxidative Stress Marker ◽  
Blink Rate ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability ◽  
Before And After ◽  
Schirmer I Test

Abstract Background To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients. Methods This study consisted of two parts, each part included 3 groups, namely dry eye without AE group, dry eye with AE group and pre-clinical dry eye with AE group. In part 1, we studied the variations of Schirmer I test and six tear compositions before and after AE (34 eyes in each group). In part 2, we studied the variations of tear meniscus height, first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness, number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity before and after AE (30 eyes in each group). Results In dry eye with AE group, Schirmer I test at 0 min after AE increased significantly compared to baseline (P < 0.001), the oxidative stress marker 8-hydroxy-2′-deoxyguanosine after AE decreased significantly compared to baseline (P = 0.035, P = 0.045), F-NITBUT and A-NITBUT after AE prolonged significantly compared to baseline (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 min after AE decreased significantly compared to baseline (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001). Besides, significant differences were also found between dry eye with AE group and dry eye without AE group at all above corresponding time point (P < 0.05). Conclusion AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye. Trial registration Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020,

scholarly journals Effects of Aerobic Exercise on Tear Secretion and Tear Film Stability in Dry Eye Patients

2021 ◽  
Author(s):  
Chao Sun ◽  
Xiaofan Chen ◽  
Yanming Huang ◽  
Huan Zou ◽  
Wei Fan ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Aerobic Exercise ◽  
Dry Eye ◽  
Tear Film ◽  
Normal Subjects ◽  
Oxidative Stress Marker ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability ◽  
Before And After

Abstract Background: To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients.Methods: Firstly we observed Schirmer Ⅰ test and 6 tear compositions detected by ELISA in 34 eyes of dry eye patients and 34 eyes of normal subjects before and after AE. Then we observed 30 eyes of dry eye patients and 30 eyes of normal subjects before and after AE, the evaluated variables included tear meniscus height (TMH), first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness (LLT), number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity.Results: In dry eye group, compared with baseline, Schirmer Ⅰ test at 0 minutes after AE increased significantly (P < 0.001), F-NITBUT and A-NITBUT at every time point after AE prolonged significantly (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 minutes after AE decreased significantly (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001), visual acuity at 10 and 20 minutes after AE improved significantly (P = 0.017, P = 0.021). The overall oxidative stress marker 8-hydroxy-2’-deoxyguanosine at 0 minutes after AE decreased significantly compared with baseline (P = 0.040).Conclusion: AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye.Trial registration: Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020, http://www.chictr.org.cn/showproj.aspx?proj=57282

scholarly journals Tear secretion and tear film stability in Nigerians with non-insulin dependent diabetes mellitus

2010 ◽  
Vol 69 (3) ◽  
Author(s):  
F. K. Idu ◽  
E. Orge
Keyword(s):  
Tear Film ◽  
Insulin Dependent Diabetes Mellitus ◽  
T Test ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability ◽  
Eye Symptoms ◽  
Niddm Patients

It has been reported that many diabetic patients complain of dry eye symptoms. Thus this study was aimed at investigating tear secretion and tear film stability in patients with non-insulin dependent diabetes mellitus (NIDDM). Eighty (80) subjects within the age range of 50-60 years with mean age of 55 ± 3.42 years were recruited for this study.They comprised of 40 NIDDM patients (19 males and 21 females) and 40 age and gender matched controls (18 males and 22 females) without diabetes. Schirmer test and invasive tear break up time(TBUT) were used to determine tear secretion and tear film stability respectively. Results showed an apparent reduction in both total and basal tear secretions for the NIDDM patients compared with that for control subjects. However this reduction was not statistically significant with the unpaired t-test. (p > 0.05). Unpaired t-test revealed a statistically significant reduction in TBUT of the NID-DM group compared with control subjects. Cor-relation analysis revealed a negative correlation between fasting blood sugar (FBS) levels and both basal and total tear secretions. (r = −0.51, p < 0.05) and (r = −0.54 p < 0.05) respectively. There was also a negative correlation between FBS and TBUT (r = −0.34 p = 0.03). The student t-test showed no influence of gender on both tear secretions and TBUT for NIDDM patients and controls. This study shows that both tear secretion and tear film stability are affected by NIDDM, and concurs with the findings that diabetic patients often complain of dry eye symptoms. (S Afr Optom 2010 69(3) 140-145)

scholarly journals Comparable effects on tear film parameters after femtosecond laser-assisted and conventional cataract surgery

2020 ◽  
Vol 40 (11) ◽  
pp. 3097-3104 ◽  
Author(s):  
Marc Schargus ◽  
Svetlana Ivanova ◽  
Gesa Stute ◽  
H. Burkhard Dick ◽  
Stephanie C. Joachim
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Dry Eye ◽  
Surgical Techniques ◽  
Tear Film ◽  
Schirmer Test ◽  
Fluorescein Staining ◽  
Significant Difference ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

Abstract Purpose Dry eye symptoms after conventional cataract surgery are a very common problem. Until now, only few data are available on objective tear film parameters in regard to femtosecond laser-assisted cataract surgery (LCS). Aim of this study was therefore to analyze and compare tear film parameter changes between LCS and conventional cataract surgery. Methods A consecutive group of 34 patients, scheduled for cataract surgery, were randomly selected for either LCS or conventional cataract surgery (17 patients/group). Tear film assessments including tear film osmolarity, Schirmer test, MMP-9 analysis via quantitative ELISA, corneal sensitivity, corneal fluorescein staining, and conjunctival fluorescein staining were sequentially evaluated pre- as well as 1 and 3 months postoperatively. Results Both groups showed no significant difference in baseline characteristics. All surgeries were performed without any complications. After 1 and 3 months, there was no statistically significant difference in regard to tear film osmolarity (1 month: p = 0.81, 3 months: p = 1.0), Schirmer test (1 month: p = 0.35, 3 month: p = 0.08), and MMP-9 concentration (1 month: p = 0.36, 3 month: p = 0.28) between the two groups. Conclusions Neither LCS nor conventional cataract surgery affected objective tear film parameters significantly during our 3-month postoperative observation period. Hence, both surgical techniques can be equally used to treat patients without prior dry eye symptoms.

scholarly journals Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

2018 ◽  
Vol 103 (8) ◽  
pp. 1024-1029 ◽  
Author(s):  
Ryan J Diel ◽  
Jodi Hwang ◽  
Zachary A Kroeger ◽  
Roy C Levitt ◽  
Constantine D Sarantopoulos ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Chronic Migraine ◽  
Dry Eye ◽  
Botulinum Toxin A ◽  
Demographic Data ◽  
Tear Film ◽  
Phenol Red ◽  
Toxin A ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

BackgroundTo evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients.MethodsRetrospective review of 76 patients who received BoNT-A for chronic migraine between 23 August 2017 and 13 December 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all comorbidities were queried via chart review. Standardised validated surveys were administered to assess symptoms prior to and after BoNT-A injection. Preinjection tear volumes were obtained using the phenol red thread (PRT) test.ResultsPreinjection migraine, photophobia and dry eye symptom scores were all significantly correlated, p<0.05, and none were associated with preinjection PRT results. After BoNT-A, improvements in migraine, photophobia and dry eye symptoms were also significantly correlated, p<0.05 and similarly did not associate with preinjection PRT results. Photophobia scores significantly improved following BoNT-A, while dry eye symptoms significantly improved in those with severe symptoms at baseline (DEQ-5 score ≥12), p=0.027. In logistic regression analysis of all individuals with dry eye symptoms (DEQ-5 ≥6), individuals with more severe dry eye symptoms were more likely improve, OR 1.27, 95% CI 1.06 to 1.51, p<0.01.ConclusionsBoNT-A significantly improved photophobia in patients being treated for migraine and also improved dry eye symptoms in patients with severe symptoms at baseline, independent of baseline tear film volume. These improvements may be due to modulation of shared trigeminal neural pathways.

scholarly journals Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use

2020 ◽  
Vol Volume 14 ◽  
pp. 1153-1159 ◽  
Author(s):  
Pedro Molina-Solana ◽  
Francisco de Borja Domínguez-Serrano ◽  
Antonio Manuel Garrido-Hermosilla ◽  
Jesús Montero-Iruzubieta ◽  
Ana Fernández-Palacín ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Dry Eye ◽  
Tear Film ◽  
Film Stability ◽  
Tear Film Stability

scholarly journals Evaluation of a new artificial tear formulation for the management of tear film stability and visual function in patients with dry eye

2017 ◽  
Vol Volume 11 ◽  
pp. 1883-1889 ◽  
Author(s):  
Gail Torkildsen ◽  
Mile Brujic ◽  
Michael Cooper ◽  
Paul Karpecki ◽  
Parag Majmudar ◽  
...  
Keyword(s):  
Dry Eye ◽  
Visual Function ◽  
Tear Film ◽  
Film Stability ◽  
Artificial Tear ◽  
Tear Film Stability

The ocular surface in children: A review of current knowledge and meta-analysis of tear film stability and tear secretion in children

2019 ◽  
Vol 17 (1) ◽  
pp. 28-39 ◽  
Author(s):  
Ngozi Charity Chidi-Egboka ◽  
Nancy E. Briggs ◽  
Isabelle Jalbert ◽  
Blanka Golebiowski
Keyword(s):  
Ocular Surface ◽  
Current Knowledge ◽  
Meta Analysis ◽  
Tear Film ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability
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