scholarly journals Evaluation of a new artificial tear formulation for the management of tear film stability and visual function in patients with dry eye

2017 ◽  
Vol Volume 11 ◽  
pp. 1883-1889 ◽  
Author(s):  
Gail Torkildsen ◽  
Mile Brujic ◽  
Michael Cooper ◽  
Paul Karpecki ◽  
Parag Majmudar ◽  
...  
Keyword(s):  
Dry Eye ◽  
Visual Function ◽  
Tear Film ◽  
Film Stability ◽  
Artificial Tear ◽  
Tear Film Stability

scholarly journals Changes in the functionality of tear film and autorefractometry reading after instillations of artificial tear products of different viscosity

2021 ◽  
Vol 21 (4) ◽  
pp. 200-204
Author(s):  
V.V. Brzheskiy ◽  
◽  
E.L. Efimova ◽  
M.A. Kopylova ◽  
P.V. Kocharina ◽  
...  
Keyword(s):  
Dry Eye ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Critical Parameters ◽  
Film Stability ◽  
Axis Orientation ◽  
Artificial Tear ◽  
Diagnostic Unit ◽  
Tear Film Stability

Aim: to study the changes in the critical parameters of tear film stability and autorefractometry in patients with mild dry eye syndrome (DES) after instilling artificial tear products of different viscosity. Patients and Methods: thirty patients aged 23–70 with mild bilateral DES were examined using the Visionix VX120+Dry Eye multi-diagnostic unit equipped with the TF-Scan to fix and assess tear film stability and tear breakup time (TBUT). The critical refraction and tear film parameters were evaluated by keratometry, corneal topography, TBUT, and tear meniscus height measurements. Next, an artificial tear product was instilled, i.e., group 1 (14 patients, 28 eyes) received a 0.15% sodium hyaluronate-based preparation, and group 2 (16 patients, 32 eyes) received a 0.4% sodium hyaluronate-based preparation. The examination was repeated after 30 sec and 5 min. Controls were seven healthy individuals (14 eyes). Results: in DES, breaks in the tear film appeared earlier and affected greater corneal surface area. A "Destabilized tear film area" parameter of the Visionix VX120+Dry Eye contributed significantly to the knowledge of tear film functionality, thereby empowering the diagnostic armamentarium in DES. As early as 30 sec after instillation of both artificial tear preparations, breakup-free time tended to increase, while the area of tear film destabilization tended to reduce. After 5 min, this trend continued to increase, particularly after instilling 0.15% sodium hyaluronate-based preparation. At the same time, changes in keratometry readings (i.e., sphere and cylinder) and astigmatism axis orientation were reported. Corneal refractive power (more in the flattest axis) increased, in particular, after the instillations of 0.15% hyaluronic acid. The range of changes was 0.00–0.75 D for the sphere power, 0.00–0.50 D for the cylinder power, and 0–69 degrees for astigmatism axis orientation. Conclusions: our findings with the Visionix VX120+Dry Eye multi-diagnostic unit demonstrate a significant variation of autorefractometry readings in DES depending on the extent of ocular surface hydration. These phenomena raise questions about the accuracy of autorefractometry readings. Therefore, autorefractometry should be performed after normalizing tear film volume and stability. Keywords: dry eye syndrome, Visionix®, autorefractometry, tearscopy, the effect of artificial tears on results. For citation: Brzheskiy V.V., Efimova E.L., Kopylova M.A. et al. Changes in the functionality of tear film and autorefractometry reading after instillations of artificial tear products of different viscosity. Russian Journal of Clinical Ophthalmology. 2021;21(4):200–204 (in Russ.). DOI: 10.32364/2311-7729-2021-21-4-200-204.

Associations between dry eye symptoms with tear film stability, volume, and osmolarity in a sample of young adults in Kuala Lumpur

2018 ◽  
Vol 10 (1) ◽  
pp. 32
Author(s):  
Bariah Mohd-Ali ◽  
MohamadHanif Hajar-Maidin ◽  
Asmah Ahmad ◽  
Zainora Mohammed ◽  
Jamaluddin Mohamed
Keyword(s):  
Young Adults ◽  
Dry Eye ◽  
Tear Film ◽  
Kuala Lumpur ◽  
Film Stability ◽  
Tear Film Stability ◽  
Eye Symptoms ◽  
Dry Eye Symptoms

scholarly journals Improved Tear Film Stability in Patients with Dry Eye After Hyaluronic Acid and Galactoxyloglucan Use

2020 ◽  
Vol Volume 14 ◽  
pp. 1153-1159 ◽  
Author(s):  
Pedro Molina-Solana ◽  
Francisco de Borja Domínguez-Serrano ◽  
Antonio Manuel Garrido-Hermosilla ◽  
Jesús Montero-Iruzubieta ◽  
Ana Fernández-Palacín ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Dry Eye ◽  
Tear Film ◽  
Film Stability ◽  
Tear Film Stability

Assessment of Tear Film Stability in Dry Eye With a Newly Developed Keratograph

Cornea ◽  
2013 ◽  
Vol 32 (5) ◽  
pp. 716-721 ◽  
Author(s):  
Jiaxu Hong ◽  
Xinghuai Sun ◽  
Anji Wei ◽  
Xinhan Cui ◽  
Yimin Li ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Film Stability ◽  
Tear Film Stability

scholarly journals Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome

2016 ◽  
Vol 95 (3) ◽  
pp. e230-e235 ◽  
Author(s):  
Ki Won Jin ◽  
Jin Woo Ro ◽  
Young Joo Shin ◽  
Joon Young Hyon ◽  
Won Ryang Wee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Film Stability ◽  
Vitamin D Levels ◽  
Tear Film Stability

scholarly journals Easy and effective test to evaluate tear-film stability for self-diagnosis of dry eye syndrome: Blinking tolerance time (BTT)

2020 ◽  
Author(s):  
Hyung Bin Hwang ◽  
Yong Ho Ku ◽  
Eun Chul Kim ◽  
Hyun Seung Kim ◽  
Man Soo Kim ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Controlled Study ◽  
Eye Disease ◽  
Cutoff Score ◽  
Time Interval ◽  
Film Stability ◽  
Tolerance Time ◽  
Tear Film Stability

Abstract Background: The tear film breakup time (tBUT) is a clinical evaluation of evaporative dry eye disease assessed by instilling topical fluorescein into the eyes. In the present study, we introduce a new diagnostic test, blinking tolerance time (BTT), for self-evaluation of tear-film stability. We compared the results with the tBUT and validated the BTT test for self-assessment of tear film instability.Methods: This was a prospective controlled study involving 212 eyes of 106 participants 20–79 years of age. A total of 114 eyes of 57 dry eye patients and 98 eyes of 49 healthy subjects were included in the study. All patients and subjects were administered the following tests to diagnose dry eye disease: Ocular Surface Disease Index, BTT, tBUT, slit-lamp examination, corneal stain score, and Schirmer I test (without anesthesia). Patients and subjects were instructed not to blink for as long possible after reset blinking. The time interval between the reset blink and the next blink was measured. The mean of 3 tBUT values in both the right and left eyes was defined as tBUTBE. Correlations between the BTT and tBUTBE were also evaluated. To evaluate the diagnostic efficacy of the BTT and tBUT tests, receiver operating characteristic (ROC) curves were generated to obtain a cutoff score, and the sensitivities of the tests against the specificity at all possible thresholds were plotted.Results: Spearman’s correlation analysis revealed a significant weakly positive correlation between BTT and tBUTBE (r = 0.447; p=0.000). The intraclass correlation coefficient (ICC) of the tBUT was 0.679 (95% confidence interval [CI]: 0.575–0.765) and the ICC of the BTT was 0.904 (95% CI: 0.867–0.932). The area under the ROC curve did not significantly differ between the tBUTBE (0.678) and BTT (0.628, p=0.641). When the cutoff value of the BTT test was set to 8.1 s, the sensitivity was 63.3% and the specificity was 56.1%.Conclusion: The BTT test is a simple, inexpensive, and effective method for self-diagnosing dry eye that can also be used in the clinical setting.

scholarly journals Insights into Tear Film Stability from Babies and Young Adults: A Study of Human Meibum Lipid Conformation and Rheology

2018 ◽  
Vol 19 (11) ◽  
pp. 3502 ◽  
Author(s):  
Poonam Mudgil ◽  
Douglas Borchman ◽  
Aparna Ramasubramanian
Keyword(s):  
Phase Transition ◽  
Dry Eye ◽  
Tear Film ◽  
Hydrocarbon Chain ◽  
Lipid Phase ◽  
Film Stability ◽  
Lipid Order ◽  
Lipid Phase Transitions ◽  
Tear Film Stability ◽  
Lipid Conformation

Babies have the most stable tears and people with dry eye have the least stable tears. Meibum may contribute to tear film stability, so in this study, the hydrocarbon chain conformation and rheology of meibum from babies was studied for the first time. Infrared spectroscopy was used to measure lipid phase transitions. Rheology was measured using Langmuir film technology. Meibum from 25 donors 1 to 13 years old was compared with meibum from 18 donors 13 to 25 years old. The phase transition temperature and lipid order (stiffness) increased with increasing age from 1 to 25 years. The increase in meibum lipid order from 1 to 25 years of age may contribute to the instability of the tear film with age and contribute to films with a higher reciprocal compressibility modulus that are not as compressible and not as viscoelastic. Changes in the lipid phase transition parameters of meibum lipid with dry eye are an exacerbation of the changes observed with age. The lower reciprocal compressibility moduli of meibum films from children and babies compared with meibum from adults reiterates higher stability in their films which spread better, resist deformation, and facilitates their ability to be quickly restored after blinking.

scholarly journals Effects of aerobic exercise on tear secretion and tear film stability in dry eye patients

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Chao Sun ◽  
Xiaofan Chen ◽  
Yanming Huang ◽  
Huan Zou ◽  
Wei Fan ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Dry Eye ◽  
Tear Film ◽  
Oxidative Stress Marker ◽  
Blink Rate ◽  
Film Stability ◽  
Tear Secretion ◽  
Tear Film Stability ◽  
Before And After ◽  
Schirmer I Test

Abstract Background To study the effects of aerobic exercise (AE) on tear secretion and tear film stability in dry eye patients. Methods This study consisted of two parts, each part included 3 groups, namely dry eye without AE group, dry eye with AE group and pre-clinical dry eye with AE group. In part 1, we studied the variations of Schirmer I test and six tear compositions before and after AE (34 eyes in each group). In part 2, we studied the variations of tear meniscus height, first and average non-invasive tear breakup time (F-NITBUT and A-NITBUT), lipid layer thickness, number of incomplete and complete blinks, partial blink rate (PBR) and visual acuity before and after AE (30 eyes in each group). Results In dry eye with AE group, Schirmer I test at 0 min after AE increased significantly compared to baseline (P < 0.001), the oxidative stress marker 8-hydroxy-2′-deoxyguanosine after AE decreased significantly compared to baseline (P = 0.035, P = 0.045), F-NITBUT and A-NITBUT after AE prolonged significantly compared to baseline (P < 0.001, P = 0.007, P = 0.036; P < 0.001, P = 0.001, P = 0.044), number of incomplete blinks and PBR at 10 min after AE decreased significantly compared to baseline (P < 0.001; P < 0.001) while number of complete blinks increased significantly (P < 0.001). Besides, significant differences were also found between dry eye with AE group and dry eye without AE group at all above corresponding time point (P < 0.05). Conclusion AE promotes tear secretion and improves tear film stability in dry eye patients. AE may be a potential treatment for dry eye. Trial registration Chinese Clinical Trial Registry, ChiCTR2000038673. Registered 27 September 2020,

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