scholarly journals Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Basil Alnasrallah ◽  
John F. Collins ◽  
L. Jonathan Zwi
Keyword(s):  
Liver Dysfunction ◽  
Recent Literature ◽  
Kidney Injury ◽  
Renal Effect ◽  
Exact Role

Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy.

scholarly journals Covid-19 and Acute Kidney Injury: Recent Updates

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Salman Tahir Shafi
Keyword(s):  
Acute Kidney Injury ◽  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Recent Literature ◽  
Kidney Injury ◽  
World Health ◽  
Related Disease ◽  
Increased Risk ◽  
The World ◽  
Health Organization

In January 2020, the pathogen was identified and named by the World Health Organization as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2). The consequent SARS-CoV-2-related disease was defined as coronavirus disease 2019 (COVID-19). As data emerged about characteristics of the disease, it was found to be associated with increased risk of acute kidney injury (AKI). We explore the recent literature and reports emerging from the epicenters of the pandemic to help our viewers understand the nature of AKI among these patients. 

Heavy metal-induced tubulointerstitial nephritis

2015 ◽  
Author(s):  
Patrick C. D’Haese ◽  
Benjamin A. Vervaet ◽  
Anja Verhulst
Keyword(s):  
Heavy Metals ◽  
Renal Damage ◽  
Recent Literature ◽  
Tubulointerstitial Nephritis ◽  
Health Hazard ◽  
Kidney Injury ◽  
Renal Handling ◽  
Important Health ◽  
Severe Chronic Kidney Disease ◽  
Low Levels

Environmental and occupational exposure to heavy metals should be considered an important health hazard, even more so since evidence has been provided in recent literature for toxic effects occurring even at low levels. The kidney is highly vulnerable to metal toxicity and the extent of renal damage depends on the nature, dose, route, and duration of exposure. Both acute and chronic intoxication have been demonstrated to cause kidney injury, with various levels of severity, ranging from tubular dysfunctions to severe chronic kidney disease. The epidemiology of heavy metals poisoning, their renal handling, pathophysiological mechanisms of renal toxicity, diagnosis, and monitoring, as well as therapeutic aspects are dealt with. The metals discussed include lead, cadmium, mercury, uranium, arsenic, and chromium.

scholarly journals Acute kidney injury after aneurysmal subarachnoid hemorrhage: is chloride really responsible?

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Gildas Gueret ◽  
Pierre Lefebvre ◽  
Pascale Le Maguet ◽  
Renaud Fabre
Keyword(s):  
Acute Kidney Injury ◽  
Subarachnoid Hemorrhage ◽  
Recent Literature ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Kidney Injury ◽  
Hypertonic Solution ◽  
Randomized Studies ◽  
The Relationship ◽  
High Chloride

Abstract Sadan et al. find an association between acute kidney injury and high chloride containing a hypertonic solution. Recent large prospective non-randomized studies bring conflicting results on the relationship between chloride and acute kidney injury. We discuss Sadan et al.’s results according to the recent literature.

Emerging Therapy-Related Kidney Disease

2009 ◽  
Vol 133 (2) ◽  
pp. 268-278
Author(s):  
Lois J. Arend ◽  
Tibor Nadasdy
Keyword(s):  
Kidney Disease ◽  
Renal Injury ◽  
Recent Literature ◽  
Renal Toxicity ◽  
Kidney Injury ◽  
Clinical History ◽  
Drug Induced ◽  
Stage Renal Disease ◽  
End Stage

Abstract Context.—Many new therapies have emerged within the last 5 to 10 years to treat a variety of conditions. Several of these have direct or indirect renal toxicities that may go undiagnosed without careful attention of the pathologist to a patient's clinical history, particularly the addition of new medications or treatments. Objective.—To discuss patterns of renal injury resulting from medications or therapeutic regimens that have been introduced within the last 10 years. Recognition of these patterns may allow the pathologist to alert the attending clinician to a possible drug-induced renal injury and prevent further deterioration of renal function and possible chronic kidney disease. Data Sources.—A review of recent literature and unpublished observations of case-derived material. Conclusions.—A number of newer therapies have emerged as agents of renal toxicity, producing a variety of pathologic changes in the kidney. The outcome can be acute or chronic glomerular, tubular, interstitial, and/or vascular injury. Some drugs will result in irreversible changes and end-stage renal disease, whereas many of the alterations can be reversed with removal of the offending agent, avoiding potential long-term kidney injury.

scholarly journals Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction

2013 ◽  
Vol 84 (1) ◽  
pp. 192-197 ◽  
Author(s):  
Charles M. van Slambrouck ◽  
Fadi Salem ◽  
Shane M. Meehan ◽  
Anthony Chang
Keyword(s):  
Liver Dysfunction ◽  
Kidney Injury ◽  
Pathologic Finding ◽  
Severe Liver ◽  
Cast Nephropathy ◽  
Severe Liver Dysfunction

scholarly journals Renohepatic crosstalk: does acute kidney injury cause liver dysfunction?

2013 ◽  
Vol 28 (7) ◽  
pp. 1634-1647 ◽  
Author(s):  
K. Lane ◽  
J. J. Dixon ◽  
I. A. M. MacPhee ◽  
B. J. Philips
Keyword(s):  
Acute Kidney Injury ◽  
Liver Dysfunction ◽  
Kidney Injury

scholarly journals Function of Astrocytes in Neuroprotection and Repair after Ischemic Stroke

2021 ◽  
pp. 1-9
Author(s):  
Shufen Zhang ◽  
Deshu Shang ◽  
Han Shi ◽  
Weiyu Teng ◽  
Li Tian
Keyword(s):  
Central Nervous System ◽  
Ischemic Stroke ◽  
Recent Literature ◽  
Current Knowledge ◽  
Cell Types ◽  
Exact Role ◽  
Exact Function ◽  
Numerous Cell ◽  
The Central Nervous System

<b><i>Background:</i></b> Astrocytes are the most numerous cell types within the central nervous system, and many efforts have been put into determining the exact role of astrocytes in neuroprotection and repair after ischemic stroke. Although numerous studies have been done in recent years, there is still no thorough understanding of the exact function of astrocytes in the whole course of the stroke. <b><i>Summary:</i></b> According to the recent literature, there are many structures and factors that play important roles in the process of ischemic stroke, among which blood-brain barrier, various growth factors, gap junctions, AQP4, and glial scars have been studied most comprehensively, and all these factors are closely related to astrocytes. The role of astrocytes in ischemic stroke, therefore, can be analyzed more comprehensively. <b><i>Key Message:</i></b> The present review mainly summarized the current knowledge about astrocytes and their potential roles after ischemic stroke.

scholarly journals Contrast-associated acute kidney injury: does it really exist, and if so, what to do about it?

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 753
Author(s):  
Wim Vandenberghe ◽  
Eric Hoste
Keyword(s):  
Acute Kidney Injury ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Animal Studies ◽  
Recent Literature ◽  
Kidney Injury ◽  
Occurrence Rate ◽  
The Past ◽  
Risk Patients ◽  
Harmful Effects

For decades, when contrast agents are administrated, physicians have been concerned because of the risk of inducing acute kidney injury (AKI). Recent literature questions the existence of AKI induced by contrast, but animal studies clearly showed harmful effects. The occurrence of contrast-associated AKI was likely overestimated in the past because of confounders for AKI. Several strategies have been investigated to reduce contrast-associated AKI but even for the most important one, hydration, there are conflicting data. Even if the occurrence rate of contrast-associated AKI is low, AKI is related to worse outcomes. Therefore, besides limiting contrast agent usage, general AKI preventive measurements should be applied in at-risk patients.

Fenofibrate attenuates ischemia reperfusion‐induced acute kidney injury and associated liver dysfunction in rats

2020 ◽  
Author(s):  
Jashanpreet Kaur ◽  
Tajpreet Kaur ◽  
Ashwani Kumar Sharma ◽  
Japneet Kaur ◽  
Harlokesh Narayan Yadav ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Liver Dysfunction ◽  
Ischemia Reperfusion ◽  
Kidney Injury
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