scholarly journals Bile cast nephropathy is a common pathologic finding for kidney injury associated with severe liver dysfunction

2013 ◽  
Vol 84 (1) ◽  
pp. 192-197 ◽  
Author(s):  
Charles M. van Slambrouck ◽  
Fadi Salem ◽  
Shane M. Meehan ◽  
Anthony Chang
Keyword(s):  
Liver Dysfunction ◽  
Kidney Injury ◽  
Pathologic Finding ◽  
Severe Liver ◽  
Cast Nephropathy ◽  
Severe Liver Dysfunction

scholarly journals Bile cast nephropathy associated with severe liver dysfunction caused by anabolic steroids

2018 ◽  
Vol 38 (2) ◽  
pp. 221-223
Author(s):  
Mónica Milla Castellanos ◽  
Eduardo Gutiérrez Martínez ◽  
Ángel Sevillano Prieto ◽  
Paola Rodríguez Ramos ◽  
Manuel Praga Terente
Keyword(s):  
Liver Dysfunction ◽  
Anabolic Steroids ◽  
Severe Liver ◽  
Cast Nephropathy ◽  
Severe Liver Dysfunction

scholarly journals Cholemic nephrosis (bile cast nephropathy) with severe liver dysfunction

2019 ◽  
Vol 75 (2) ◽  
pp. 216-218
Author(s):  
Tanushri Mukherjee ◽  
Inam Danish Khan ◽  
Rena Guha ◽  
Tanmay Ganguly
Keyword(s):  
Liver Dysfunction ◽  
Severe Liver ◽  
Cast Nephropathy ◽  
Severe Liver Dysfunction

scholarly journals Bile Cast Nephropathy: A Pathologic Finding with Manifold Causes Displayed in an Adult with Alcoholic Steatohepatitis and in a Child with Wilson’s Disease

2018 ◽  
Vol 8 (3) ◽  
pp. 207-215 ◽  
Author(s):  
Jose Torrealba ◽  
Nathan T. Sweed ◽  
Daniel Burguete ◽  
Allen R. Hendricks
Keyword(s):  
Epithelial Cells ◽  
Wilson’S Disease ◽  
Case Reports ◽  
Kidney Injury ◽  
Wilson's Disease ◽  
Pathologic Finding ◽  
Severe Liver ◽  
Alcoholic Steatohepatitis ◽  
Cast Nephropathy ◽  
Wide Range

Bile cast nephropathy (BCN) is seen in patients who have acute kidney injury and severe hyperbilirubinemia due to a wide range of hepatobiliary system diseases. Findings seen by renal biopsy include acute tubular injury with necrotic and sloughed epithelial cells, yellow-green pigment within tubular epithelial cells, and pigmented granular casts. Hall’s special stain for bile turns these casts green. In recent years, BCN has been described in a small number of case reports and clinical studies primarily in the setting of severe liver dysfunction. We present 2 diverse cases of BCN. The first involves an adult with hepatorenal syndrome secondary to alcoholic steatohepatitis and early cirrhosis. Second, we describe the first reported case of BCN in a child with fulminant hepatic failure due to Wilson’s disease. Our cases expand the spectrum of causative diseases, and they provide further evidence that BCN is a distinct pathologic entity which may be found in both adult and pediatric patients with a variety of severe liver diseases.

scholarly journals Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kevin Roedl ◽  
Dominik Jarczak ◽  
Andreas Drolz ◽  
Dominic Wichmann ◽  
Olaf Boenisch ◽  
...  
Keyword(s):  
Critically Ill ◽  
Liver Dysfunction ◽  
Critically Ill Patients ◽  
Severity Of Illness ◽  
University Hospital ◽  
Severe Liver ◽  
Saps Ii ◽  
Severe Liver Dysfunction ◽  
Global Threat ◽  
The University

Abstract Background SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunction (SLD) in critically ill with COVID-19 are lacking. We evaluated the occurrence, clinical characteristics and outcome of SLD in critically ill patients with COVID-19. Methods Clinical course and laboratory was analyzed from all patients with confirmed COVID-19 admitted to ICU of the university hospital. SLD was defined as: bilirubin ≥ 2 mg/dl or elevation of aminotransferase levels (> 20-fold ULN). Results 72 critically ill patients were identified, 22 (31%) patients developed SLD. Presenting characteristics including age, gender, comorbidities as well as clinical presentation regarding COVID-19 overlapped substantially in both groups. Patients with SLD had more severe respiratory failure (paO2/FiO2: 82 (58–114) vs. 117 (83–155); p < 0.05). Thus, required more frequently mechanical ventilation (95% vs. 64%; p < 0.01), rescue therapies (ECMO) (27% vs. 12%; p = 0.106), vasopressor (95% vs. 72%; p < 0.05) and renal replacement therapy (86% vs. 30%; p < 0.001). Severity of illness was significantly higher (SAPS II: 48 (39–52) vs. 40 (32–45); p < 0.01). Patients with SLD and without presented viremic during ICU stay in 68% and 34%, respectively (p = 0.002). Occurrence of SLD was independently associated with presence of viremia [OR 6.359; 95% CI 1.336–30.253; p < 0.05] and severity of illness (SAPS II) [OR 1.078; 95% CI 1.004–1.157; p < 0.05]. Mortality was high in patients with SLD compared to other patients (68% vs. 16%, p < 0.001). After adjustment for confounders, SLD was independently associated with mortality [HR3.347; 95% CI 1.401–7.999; p < 0.01]. Conclusion One-third of critically ill patients with COVID-19 suffer from SLD, which is associated with high mortality. Occurrence of viremia and severity of illness seem to contribute to occurrence of SLD and underline the multifactorial cause.

Purine Analogs for Patients with Non-Hodgkin Lymphoma and Severe Liver Dysfunction

2018 ◽  
Vol 18 ◽  
pp. S291-S292
Author(s):  
Tamer Khashab ◽  
Ashley Manganiello ◽  
Julianne Hibbs ◽  
Thomas Oliver ◽  
Jonathan Doroshow ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Liver Dysfunction ◽  
Severe Liver ◽  
Non Hodgkin Lymphoma ◽  
Purine Analogs ◽  
Severe Liver Dysfunction

Severe liver dysfunction in patients withMycoplasma pneumoniaeinfection

2010 ◽  
Vol 52 (2) ◽  
pp. e105-e107 ◽  
Author(s):  
Akitoshi Murayama ◽  
Daiki Abukawa ◽  
Keiko Watanabe ◽  
Hiroaki Umebayashi ◽  
Tetsuji Inagaki ◽  
...  
Keyword(s):  
Liver Dysfunction ◽  
Severe Liver ◽  
Severe Liver Dysfunction

scholarly journals Anorexia Nervosa with Severe Liver Dysfunction and Subsequent Critical Complications.

1999 ◽  
Vol 38 (7) ◽  
pp. 575-579 ◽  
Author(s):  
Sachiyo FURUTA ◽  
Yukako OZAWA ◽  
Kiyoshi MAEJIMA ◽  
Hirokazu TASHIRO ◽  
Tetsuji KITAHORA ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Liver Dysfunction ◽  
Severe Liver ◽  
Severe Liver Dysfunction

scholarly journals An evaluation of the usefulness of extracorporeal liver support techniques in patients with severe liver dysfunction

2019 ◽  
Vol 15 (1) ◽  
pp. 99-112 ◽  
Author(s):  
Mariusz Piechota ◽  
Anna Piechota ◽  
Małgorzata Misztal ◽  
Szymon Bernas ◽  
Iwona Pietraszek-Grzywaczewska
Keyword(s):  
Liver Dysfunction ◽  
Severe Liver ◽  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Severe Liver Dysfunction
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