scholarly journals Electrochemical Determination of Metronidazole in Tablet Samples Using Carbon Paste Electrode

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Yosef Nikodimos ◽  
Meareg Amare
Keyword(s):  
Correlation Coefficient ◽  
Carbon Paste Electrode ◽  
Reduction Peak ◽  
Carbon Paste ◽  
Peak Potential ◽  
Peak Current ◽  
Potential Shift ◽  
Scan Rate ◽  
Paste Electrode

Cyclic voltammetric investigation of metronidazole at carbon paste electrode revealed an irreversible reduction peak centered at about −0.4 V. Observed peak potential shift with pH in the range 2.0 to 8.5 indicated the involvement of protons during the reduction of metronidazole, whereas the peak potential shift with scan rate in the range 10–250 mV/s confirmed the irreversibility of the reduction reaction. A better correlation coefficient for the dependence of peak current on the scan rate than on the square root of scan rate indicated an adsorption controlled kinetics. Under the optimized method and solution parameters, an excellent linearity between the reductive peak current and the concentration of metronidazole was observed in the concentration range 1.0 × 10−6to 5.0 × 10−4 M with a correlation coefficient, method detection limit (based ons=3σ), and limit of quantification of 0.999, 2.97 × 10−7 M and 9.91 × 10−7 M, respectively. Good recovery results for spiked metronidazole in tablet samples and selective determination of metronidazole in tablet formulations in the presence of selected potential interferents such as rabeprazole, omeprazole, and tinidazole confirmed the potential applicability of the developed method for the determination of metronidazole in real samples like pharmaceutical tablets.

scholarly journals A Sensitive and Low-cost Analytical Method for the Electrochemical Determination of Quercetin, Based on 1-Ethylpyridinium Bromide/Carbon Paste Composite Electrode

2015 ◽  
Vol 7 (2) ◽  
pp. 27 ◽  
Author(s):  
Francis Tchieno ◽  
Ignas Tonle ◽  
Evangeline Njanja ◽  
Emmanuel Ngameni
Keyword(s):  
Carbon Paste Electrode ◽  
Analytical Method ◽  
Composite Electrode ◽  
Low Cost ◽  
Reduction Peak ◽  
Cyclic Voltammogram ◽  
Current Response ◽  
Carbon Paste ◽  
Paste Electrode

We report a simple, sensitive and low-cost electrochemical procedure for the quantification of quercetin (QCT), a flavonoid and an antioxidant, based on 1-ethylpyridinium bromide modified carbon paste electrode. A 1-ethylpyridinium bromide/carbon paste composite electrode was used. The cyclic voltammogram of QCT showed two oxidation peaks at +0.575 V (vs Ag/AgCl/3M KCl) and +0.865 V (vs Ag/AgCl/3M KCl), and a reduction peak at +0.371 V (vs Ag/AgCl/3M KCl) in HCl/KCl solution at pH 1. Differential pulse voltammetry (DPV) analysis in HCl/KCl at pH 1 showed three well-defined oxidation peaks while a single peak was recorded in phosphate buffer at pH 3. The peak currents of QCT significantly increased at the 1-ethylpyridinium bromide modified electrode in comparison with those recorded at the bare carbon paste electrode. This allowed the use of adsorptive stripping voltammetry to develop a simple and sensitive electroanalytical method for the determination of QCT. Key experimental parameters such as pH of the supporting electrolyte, the preconcentration time, the electrolysis potential, electrode composition, QCT concentration and interferents were investigated. The current response was found to be directly proportional to the concentration of QCT in the range from 2.48 x 10-7 M to 7.43 x 10-6 M, leading to a detection limit of 4.48 x 10-8 M. The developed analytical method was successfully applied to the determination of QCT in human urine samples.

scholarly journals A zeolite modified carbon paste electrode based on copper exchanged clinoptilolite nanoparticles for voltammetric determination of metronidazole

RSC Advances ◽  
2017 ◽  
Vol 7 (23) ◽  
pp. 14247-14253 ◽  
Author(s):  
Elahe Shahnazari-Shahrezaie ◽  
Alireza Nezamzadeh-Ejhieh
Keyword(s):  
Carbon Paste Electrode ◽  
Voltammetric Determination ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Peak Current ◽  
Paste Electrode

Modified carbonpaste elelctrode with Cu(ii)-exchanged clinoptilolite nanoparticles showed increased peak current in the presence of metronidazole.

scholarly journals Developing an electrochemical sensor based on a carbon paste electrode modified with ZnO nanoparticles synthesized by microwave for determination of chlorpheniramine maleate

2021 ◽  
Vol 4 (01) ◽  
pp. 16-25
Author(s):  
Hamideh Asadollahzadeh
Keyword(s):  
Carbon Paste Electrode ◽  
Zno Nanoparticles ◽  
Electrochemical Behaviour ◽  
Differential Pulse ◽  
Oxidation Potential ◽  
Carbon Paste ◽  
Chlorpheniramine Maleate ◽  
Peak Current ◽  
Paste Electrode

Zinc oxide (ZnO) nanoparticles with an average size of 60 nm have been successfully prepared by microwave irradiation. Carbon paste electrode (CPE) was modified with ZnO nanoparticles and used for the electrochemical oxidation of chlorpheniramine maleate (CPM). Cyclic voltammetry (CV) study of the modified electrode indicated that the oxidation potential shifted towards a lower potential by approximately 106 mV and the peak current was enhanced by 2 fold in comparison to the bare CPE (ZnO/CPE-CV). The electrochemical behaviour was further described by characterization studies of scan rate, pH and concentration of CPM. Under the optimal conditions, the peak current was proportional to CPM concentration in the range of 8.0 ×10-7 to 1.0 × 10-3 mol L-1 with a detection limit of 5.0 × 10-7 mol L-1 by differential pulse voltammetry (DPV). The peak current of CPM is linear in the concentration range of 0.8 - 1000 µM (R2=0.998). The ZnO/CPE has good reproducibility and high stability for the determination of CPM using this electrode. The proposed method was successfully applied to the determination of CPM in pharmaceutical samples. In addition, the important analytical parameters were compared with other methods which show that ZnO/CPE-CV procedure is comparable to recently reported methods.

scholarly journals Electrochemical Behaviour of Tinidazole at 1,4-Benzoquinone Modified Carbon Paste Electrode and Its Direct Determination in Pharmaceutical Tablets and Urine by Differential Pulse Voltammetry

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yosef Nikodimos ◽  
Beyene Hagos
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Direct Determination ◽  
Differential Pulse ◽  
Modified Carbon Paste Electrode ◽  
Reduction Peak ◽  
Current Response ◽  
Carbon Paste ◽  
Paste Electrode

A simple and highly sensitive electrochemical method based on a 1,4-benzoquinone modified carbon paste electrode (1,4-BQMCPE) was described for the determination of tinidazole (TDZ). In Britton Robinson buffer solution, TDZ yields well-defined irreversible reduction peak at −0.344 V on a 1,4-BQMCPE. Compared with that on a bare CPE, the reduction peak of TDZ increased significantly on the modified CPE and the effects of different parameters on the voltammetric responses were also investigated. Differential pulse voltammetric method was proposed and optimized for TDZ determination and its reductive peak current response at 1,4-BQMCPE was found to show linear dependence on the concentration of TDZ in the range of 1.0 × 10−6 to 5.0 × 10−4 M with a linear regression equation, correlation coefficient, limit of detection (LOD), and limit of quantification (LOQ) of IPC (μA) = 0.19958 + 0.02657C (μM), 0.99486, 1.10 × 10−7 M, and 3.77 × 10−7, respectively. Excellent recovery results for spiked TDZ in pharmaceutical tablet samples ranging within 97.44–97.51% and in urine ranging within 95.37–96.91% were observed. The selectivity of the method for TDZ was further studied in the presence of selected potential interferents and confirmed the potential applicability of the developed method for the determination of TDZ.

scholarly journals Modification of Carbon Paste Electrode Using Calyx[6]Arene-TiO2 Nanocomposite for Determination of Cu2+ ion Based on Cyclic Voltammetry

2021 ◽  
Vol 12 (3) ◽  
pp. 2843-2851
Keyword(s):  
Cyclic Voltammetry ◽  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Supporting Electrolyte ◽  
Rate Variation ◽  
Carbon Paste ◽  
Relative Standard ◽  
Scan Rate ◽  
Paste Electrode

In the present study, an electrochemical sensor for the determination of Cu(II) ions in aqueous solutions was introduced. This study proposes an electrochemical method using the calyx [6]arene-TiO2 nanocomposite modified carbon paste electrode (calyx[6]arene-TiO2/CPE) for the determination of metal Cu2+ ion. Calyx[6]arene-TiO2 were synthesized using the hydrolysis method as the Cu-binding ionophore. The electrode surface was studied by scanning electron microscopy (SEM), and the reduction and oxidation processes were studied by cyclic voltammetry (CV) techniques. The effect of modifier composition, scan rate, variation concentration, repeatability, and type of supporting electrolyte on the determination of metal ions was investigated. The best composition was 0.005 g calyx[6]arene-TiO2 in the carbon paste electrode with a scan rate of 0.5 V/s. The modified electrodes showed good performance for Cu2+ ion detection. Under optimum experimental conditions, a linear range for metal Cu(II) ions was from 0.1, 0.3, 0.5, 0.8, and 1.0 ppm with respective currents of 500, 550, 600, 700, and 800 µA. The limit of detection (LOD) for metal Cu2+ ions is found to be 0.022 ppm with a relative standard deviation (%RSD) of 0.011%.

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