scholarly journals Electrochemical Behaviour of Tinidazole at 1,4-Benzoquinone Modified Carbon Paste Electrode and Its Direct Determination in Pharmaceutical Tablets and Urine by Differential Pulse Voltammetry

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yosef Nikodimos ◽  
Beyene Hagos
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Direct Determination ◽  
Differential Pulse ◽  
Modified Carbon Paste Electrode ◽  
Reduction Peak ◽  
Current Response ◽  
Carbon Paste ◽  
Paste Electrode

A simple and highly sensitive electrochemical method based on a 1,4-benzoquinone modified carbon paste electrode (1,4-BQMCPE) was described for the determination of tinidazole (TDZ). In Britton Robinson buffer solution, TDZ yields well-defined irreversible reduction peak at −0.344 V on a 1,4-BQMCPE. Compared with that on a bare CPE, the reduction peak of TDZ increased significantly on the modified CPE and the effects of different parameters on the voltammetric responses were also investigated. Differential pulse voltammetric method was proposed and optimized for TDZ determination and its reductive peak current response at 1,4-BQMCPE was found to show linear dependence on the concentration of TDZ in the range of 1.0 × 10−6 to 5.0 × 10−4 M with a linear regression equation, correlation coefficient, limit of detection (LOD), and limit of quantification (LOQ) of IPC (μA) = 0.19958 + 0.02657C (μM), 0.99486, 1.10 × 10−7 M, and 3.77 × 10−7, respectively. Excellent recovery results for spiked TDZ in pharmaceutical tablet samples ranging within 97.44–97.51% and in urine ranging within 95.37–96.91% were observed. The selectivity of the method for TDZ was further studied in the presence of selected potential interferents and confirmed the potential applicability of the developed method for the determination of TDZ.

Enhanced Electrochemical Determination Of Riboflavin In Biological And Pharmaceutical Samples At Poly (Arginine) Modified Carbon Paste Electrode

2019 ◽  
Vol 14 (4) ◽  
pp. 216-223 ◽  
Author(s):  
Girish Tigari ◽  
J.G. Manjunatha ◽  
D.K. Ravishankar ◽  
G. Siddaraju
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Differential Pulse ◽  
Modified Carbon Paste Electrode ◽  
Current Response ◽  
Carbon Paste ◽  
Serum Samples ◽  
Buffer Solution ◽  
Paste Electrode

An electrogenerated Polyarginine modified carbon paste electrode (PAMCPE) was fabricated through a simple electropolymerization procedure. The devised electrode was characterized by cyclic voltammetry (CV) and Field Emission Scanning Electron Microscopy (FESEM). This electrode was utilized for electrocatalytic estimation of Riboflavin (RF) and its instantaneous resolution with ascorbic acid (AA) and folic acid (FA) in phosphate buffer solution (PBS) of pH 6.0 by differential pulse voltammetry (DPV). It was observed to be a very responsive electrode for the electrochemical detection and quantification of RF. It was revealed that PAMCPE generates higher current response towards RF contrast to the bare carbon paste electrode (BCPE). Under optimized condition, the RF oxidation current values were linearly reliant on the RF concentration increment with a limit of detection (LOD) of 9.3·10-8 M using DPV. The stable PAMCPE was effectively applied for estimation of RF in B-complex pill and complex human blood serum samples.

scholarly journals MODIFICATION OF CARBON PASTE ELECTRODE WITH CROWN ETHER (DIBENZO-18-CROWN-6) FOR ASCORBIC ACID ANALYSIS USING DIFFERENTIAL PULSE VOLTAMMETRY METHOD

2016 ◽  
Vol 11 (2) ◽  
pp. 175
Author(s):  
Irdhawati Irdhawati ◽  
Manuntun Manurung ◽  
Anisha Maulinasari
Keyword(s):  
Ascorbic Acid ◽  
Crown Ether ◽  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Differential Pulse ◽  
Modified Carbon Paste Electrode ◽  
Range Limit ◽  
Carbon Paste ◽  
Paste Electrode

In this research, the modified carbon paste electrode with crown ether (dibenzo-18-crown-6) has been prepared, for determination of ascorbic acid. Some of parameters observed were optimization of crown ether composition in carbon paste, pH of solution, linear concentration range, limit of detection, reproducibility, and recovery. The optimum performance of the prepared electrode was applied for determination of commercialsampleswhich contain of ascorbic acid. The result of this research showsthat the optimum composition of crown ether in carbon paste is 0.6 % at pH 4. Linear range of concentration obtained is from 2 - 200 μM. The detection limit and percentage of recovery are 1.243 μM and 101.31 %, respectively. The modified electrode has HorRat value less than 2, it indicates a good reproducibility. Analysis of 4 commercial samples which contain of ascorbic acid were in agreement with the content listed in the label with the suitability of 94 - 100 %.

scholarly journals MODIFICATION OF CARBON PASTE ELECTRODE WITH CROWN ETHER (DIBENZO-18-CROWN-6) FOR ASCORBIC ACID ANALYSIS USING DIFFERENTIAL PULSE VOLTAMMETRY METHOD

2016 ◽  
Vol 11 (2) ◽  
pp. 175
Author(s):  
Irdhawati Irdhawati ◽  
Manuntun Manurung ◽  
Anisha Maulinasari
Keyword(s):  
Ascorbic Acid ◽  
Crown Ether ◽  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Differential Pulse ◽  
Modified Carbon Paste Electrode ◽  
Range Limit ◽  
Carbon Paste ◽  
Paste Electrode

In this research, the modified carbon paste electrode with crown ether (dibenzo-18-crown-6) has been prepared, for determination of ascorbic acid. Some of parameters observed were optimization of crown ether composition in carbon paste, pH of solution, linear concentration range, limit of detection, reproducibility, and recovery. The optimum performance of the prepared electrode was applied for determination of commercialsampleswhich contain of ascorbic acid. The result of this research showsthat the optimum composition of crown ether in carbon paste is 0.6 % at pH 4. Linear range of concentration obtained is from 2 - 200 μM. The detection limit and percentage of recovery are 1.243 μM and 101.31 %, respectively. The modified electrode has HorRat value less than 2, it indicates a good reproducibility. Analysis of 4 commercial samples which contain of ascorbic acid were in agreement with the content listed in the label with the suitability of 94 - 100 %.

scholarly journals A Voltammetric Technique Using A Modified Carbon Paste Electrode For The Determination Of Aclonifen

2015 ◽  
Vol 22 (3) ◽  
pp. 451-458
Author(s):  
Vít Novotný ◽  
Jiří Barek
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Differential Pulse ◽  
Modified Carbon Paste Electrode ◽  
Potential Range ◽  
Carbon Paste ◽  
Calibration Dependence ◽  
Paste Electrode ◽  
Voltammetric Technique

Abstract A method for the determination of aclonifen at a carbon paste electrode modified with tricresyl phosphate has been developed. The optimum electrochemical regime proved to be differential pulse voltammetry (DPV) in the negative potential range from −200 to −1600 mV. The optimum pH for the determination proved to be pH = 8. The calibration dependence is linear and the limit of detection achieved for the method was 2·10−6 mol/dm3. The method is fast, reliable and it is suitable for the detection of aclonifen in the concentration range from 2·10−6 to 1·10−4 mol/dm3.

scholarly journals A Sensitive and Low-cost Analytical Method for the Electrochemical Determination of Quercetin, Based on 1-Ethylpyridinium Bromide/Carbon Paste Composite Electrode

2015 ◽  
Vol 7 (2) ◽  
pp. 27 ◽  
Author(s):  
Francis Tchieno ◽  
Ignas Tonle ◽  
Evangeline Njanja ◽  
Emmanuel Ngameni
Keyword(s):  
Carbon Paste Electrode ◽  
Analytical Method ◽  
Composite Electrode ◽  
Low Cost ◽  
Reduction Peak ◽  
Cyclic Voltammogram ◽  
Current Response ◽  
Carbon Paste ◽  
Paste Electrode

We report a simple, sensitive and low-cost electrochemical procedure for the quantification of quercetin (QCT), a flavonoid and an antioxidant, based on 1-ethylpyridinium bromide modified carbon paste electrode. A 1-ethylpyridinium bromide/carbon paste composite electrode was used. The cyclic voltammogram of QCT showed two oxidation peaks at +0.575 V (vs Ag/AgCl/3M KCl) and +0.865 V (vs Ag/AgCl/3M KCl), and a reduction peak at +0.371 V (vs Ag/AgCl/3M KCl) in HCl/KCl solution at pH 1. Differential pulse voltammetry (DPV) analysis in HCl/KCl at pH 1 showed three well-defined oxidation peaks while a single peak was recorded in phosphate buffer at pH 3. The peak currents of QCT significantly increased at the 1-ethylpyridinium bromide modified electrode in comparison with those recorded at the bare carbon paste electrode. This allowed the use of adsorptive stripping voltammetry to develop a simple and sensitive electroanalytical method for the determination of QCT. Key experimental parameters such as pH of the supporting electrolyte, the preconcentration time, the electrolysis potential, electrode composition, QCT concentration and interferents were investigated. The current response was found to be directly proportional to the concentration of QCT in the range from 2.48 x 10-7 M to 7.43 x 10-6 M, leading to a detection limit of 4.48 x 10-8 M. The developed analytical method was successfully applied to the determination of QCT in human urine samples.

scholarly journals Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite

2021 ◽  
Vol 19 (1) ◽  
pp. 875-883
Author(s):  
Nevila Broli ◽  
Majlinda Vasjari ◽  
Loreta Vallja ◽  
Sonila Duka ◽  
Alma Shehu ◽  
...  
Keyword(s):  
Carbon Paste Electrode ◽  
Beta Blockers ◽  
High Sensitivity ◽  
Modified Carbon Paste Electrode ◽  
Current Response ◽  
Carbon Paste ◽  
Linear Calibration ◽  
Pharmaceutical Tablets ◽  
Paste Electrode

Abstract In this study, a simple voltammetric method was reported for independent determination of propranolol (PROP) and atenolol (ATN) in pharmaceutical tablets using carbon paste electrode modified with natural Ilmenite (CPE-I). The analytical performance of the modified sensor was evaluated using the square wave voltammetry and cyclic voltammetry for determination of both β(beta) blockers in 0.1 mol L−1 of sulfuric acid solution (H2SO4). The signal obtained with modified carbon paste electrode in 0.1 mol L−1 of H2SO4 showed a good electrocatalytic activity toward the oxidations of PROP and ATN compared with the bare one. The enhanced oxidation peak current response can be attributed to the catalytic effect of the ilmenite nanomaterial incorporated into the carbon paste electrode. Under optimal condition, good linear calibration curves were obtained ranging from 0.20 to 8.9 mmol L−1 for PROP and 2.0 to 9.9 µmol L−1 for ATN, with detection limits of 80 and 0.31 µmol L−1, respectively. The CPE-I sensor had good repeatability and reproducibility (RSD ≤ 3.2%) and high sensitivity for the detection of both ATN and PROP. The proposed sensor was applied for detection of these drugs in pharmaceutical tablets. The obtained results indicate that the voltammetric CPE-I sensor could be an alternative method for the routine quality control of the β blockers in complex matrices.

Voltammetric study of secnidazole and its determination in pharmaceutical tablet using 1, 4-benzoquinone modified carbon paste electrode

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Limit Of Quantification ◽  
Pharmaceutical Tablet ◽  
Relative Standard ◽  
Paste Electrode

In this study voltammetric behaviour of secnidazole (SCZ) at 1, 4-Benzoquinone Modified Carbon Paste Electrode (1,4-BQMCPE) was investigated in Britton Robinson buffer solution using cyclic voltammetric technique. A well-defined cathodic peak was observed for the SCZ in the entire pH range. The current increases steadily with scan rate and the results indicated that the process is irreversible reduction and adsorption controlled. The number of electrons transferred and different kinetic parameters like transfer coefficient and rate constant were calculated by using cyclic voltammetry technique. Differential pulse voltammetric method has been used for the determination of SCZ content in pharmaceutical tablet. This method enabled to determine SCZ in the concentration range 1.0 × 10-8 to 4.0 × 10-4 M. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 2.13 × 10-9 and 2.85 × 10-9 respectively. The method was applied to determine the content of SCZ in different sample solutions of SCZ tablet with excellent recovery and relative standard deviation results (99.892±1.53 respectively) for spiked standard SCZ in tablet sample solutions. The selectivity of the method for SCZ was further studied in the presence of selected potential interferents such as fluconazole, azithromycin etc and confirmed the potential applicability of the developed method for the determination of SCZ in real pharmaceutical tablets.

Indirect Differential Pulse Voltammetric Determination of Fluoride Ions at Carbon Paste Electrode Modified with Porous and Electroactive Fe3+/Fe2+ Based-Metal Organic Frameworks Type MIL-101(Fe)

2021 ◽  
Author(s):  
Ashraf Mahmoud ◽  
Mater Mahnashi ◽  
Samer Abu-Alrub ◽  
Saad Kahatani ◽  
Mohamed El-Wekil
Keyword(s):  
Carbon Paste Electrode ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
Metal Organic Frameworks ◽  
Differential Pulse ◽  
Carbon Paste ◽  
X Ray ◽  
Metal Organic ◽  
Paste Electrode

Abstract An innovative and reliable electrochemical sensor was proposed for simple, sensitive and selective determination of F- ions. The sensor is based on the fabrication of porous and electroactive Fe-based metal organic frameworks [MIL-101(Fe)]. It was blended with graphite powder and liquid paraffin oil to from carbon paste electrode (CPE). The MIL-101(Fe)@CPE was characterized using different techniques such as scanning electron microscope, powder X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, energy dispersive X-ray, cyclic voltammetry, electrochemical impedance spectroscopy, differential pulse voltammetry. The MIL-101(Fe)@CPE exhibited two redox peaks (anodic and cathodic) corresponding to Fe3+ and Fe2+, respectively. The determination of F- ions based on the formation of a stable fluoroferric complex with Fe3+/ Fe2+, decreasing the currents of redox species. It was found that the anodic peak current (Ipa) is linearly proportional to the concentration of F- in the range of 0.67-130 µM with a limit of detection (S/N=3) of 0.201 µM. The electrode exhibited good selectivity towards F- detection with no significant interferences from common anions. The as-fabricated sensor was applied for the determination of F- in environmental water samples with recoveries % and RSDs % in the range of 98.1-102.4 % and 2.4-3.7 %, respectively.

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