scholarly journals Applicability of Isolates and Fractions of Plant Extracts in Murine Models in Type II Diabetes: A Systematic Review

2016 ◽  
Vol 2016 ◽  
pp. 1-25 ◽  
Author(s):  
Gabriela Diniz Pinto Coelho ◽  
Vanessa Soares Martins ◽  
Laura Vieira do Amaral ◽  
Rômulo Dias Novaes ◽  
Mariáurea Matias Sarandy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Plant Extracts ◽  
Type Ii Diabetes ◽  
Study Groups ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Glucose Levels ◽  
Animal Data ◽  
Plasma Insulin Levels ◽  
Clinical Conditions

Type II diabetes mellitus is one of the most common public health problems worldwide. Its increasing prevalence in several countries and the difficult metabolic control of individuals with the disease justify studying strategies for primary prevention. The population has sought alternative and cheaper ways to treat the disease, including the use of plants considered medicinal by the population. In this study, we carried out a systematic review on the applicability of isolates and fractions of plant extracts in animal models in type II diabetes. A literature search was performed in MEDLINE/PubMed and Scopus databases. Studies using other experimental animals (horses, rabbits, and monkeys) and humans as well as articles in Chinese, German, and Russian were excluded. We assessed the quality of the studies included by using the criteria described in the ARRIVE guidelines. In general, the animals that received fractions or isolates presented reduced blood glucose levels, normalization of body weight and plasma insulin levels, and reduced total triglycerides and cholesterol. In addition, we observed wide variation among the analyzed parameters, which hindered comparison between the studies found. In further studies, standardized reports and experimental design would help to establish comparable study groups and advance the overall knowledge, thus facilitating translatability from animal data to human clinical conditions.

Role of yoga for patients with type II diabetes mellitus: A systematic review and meta-analysis

2016 ◽  
Vol 25 ◽  
pp. 104-112 ◽  
Author(s):  
Vinod Kumar ◽  
Aarti Jagannathan ◽  
Mariamma Philip ◽  
Arun Thulasi ◽  
Praveen Angadi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type Ii Diabetes ◽  
Meta Analysis ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii

A Systematic Review on Organophosphate Pesticide and Type II Diabetes Mellitus

2020 ◽  
Vol 16 (6) ◽  
pp. 586-597 ◽  
Author(s):  
Jothi Lakshmi ◽  
Krishnendu Mukhopadhyay ◽  
Padmavathi Ramaswamy ◽  
Shriraam Mahadevan
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Insulin Resistance ◽  
Type Ii Diabetes ◽  
Chronic Exposure ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Organophosphate Pesticide ◽  
High Association ◽  
Acute And Chronic Exposure

Organophosphate (OP) pesticides are extremely poisonous and they affect the glucose breakdown in numerous and mechanism. There are higher evidence of stimulating diabetes mellitus through OP pesticides especially the type II diabetes. The upsurge in the level of glucose (hyperglycemia), and insulin resistance along with their related outcomes are discussed in this review. The data related to investigational and clinical techniques endorse a connection amid such molecular mechanism and compounds of OPs. Numerous studies conducted till March 2018 have reported OP’ exposures and diabetes-related outcomes. The acute and chronic exposure in case of these insecticides and diabetesrelated outcomes are defined in this study. Initially, it was declared that OPs prompt to hyperglycemia. Then, a high association of glucose in blood beside insulin was found out. The affirmation from some clinical as well as investigational studies supported a connection amid exposure to OP and diabetes, yet in maximum number of instances, non-specific diabetes occurs.

Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats

2004 ◽  
Vol 82 (3) ◽  
pp. 175-182 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Kentaro Wakabayashi ◽  
Tsuneo Kobayashi ◽  
Katsuo Kamata
Keyword(s):  
Type Ii Diabetes ◽  
Mesenteric Artery ◽  
Matched Control ◽  
Contractile Response ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Rats ◽  
Vascular Endothelial ◽  
Type Ii ◽  
Adult Rats ◽  
Plasma Insulin Levels

We used the partial protection exerted by suitable dosages of nicotinamide against the β-cytotoxic effect of streptozotocin (STZ) to create an experimental diabetic syndrome in adult rats that appears closer to type II diabetes mellitus than other available animal models. The dosage of 230 mg/kg of nicotinamide given intraperitoneally 15 min before STZ administration (65 mg/kg i.v.) yielded animals with hyperglycemia (187.8 ± 17.8 vs. 103.8 ± 2.8 mg/dL in controls; P < 0.001) and preservation of plasma insulin levels. This study assessed the relationship between endothelial dysfunction and agonist-induced contractile responses in such rats. In the thoracic aorta, the acetylcholine (ACh) induced relaxation was significantly reduced and the noradrenaline (NA) induced contractile response was significantly increased in diabetic rats compared with age-matched control rats. In the superior mesenteric artery, the ACh-induced relaxation was similar in magnitude between diabetic and age-matched control rats; however, the ACh-induced endothelium-derived hyperpolarizing factor (EDHF) type relaxation was significantly weaker in diabetic rats than in the controls. The phenylephrine (PE) induced contractile response was not different between the two groups. The plasma concentration of NOx (NO2– + NO3–) was significantly lower in diabetic rats than in control rats. We conclude that vasomotor activities in conduit arteries are impaired in this type II diabetes model.Key words: aorta, contraction, endothelium-derived hyperpolarizing factor, endothelium-mediated relaxation, mesenteric artery, type II diabetes.

Effect of sulfonylurea therapy and plasma glucose levels on hemoglobin A1c in type II diabetes mellitus

1981 ◽  
Vol 70 (2) ◽  
pp. 373-378 ◽  
Author(s):  
T.A. Schultz ◽  
S.B. Lewis ◽  
J.L. Davis ◽  
C.R. Rost ◽  
M.M. Bliziotes
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Hemoglobin A1c ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Glucose Levels

scholarly journals Controlled Type -II Diabetes Mellitus - No More Contra-Indication for Delayed Loading of Two Piece Dental Implants - A Case Report

2019 ◽  
Vol 7 (1) ◽  
pp. 1-4
Author(s):  
Alekhya Ayalapuram
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Type Ii Diabetes ◽  
Survival Rates ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Obesity Prevalence ◽  
Glucose Levels ◽  
Blood Glucose Levels

With changing lifestyle and increasing obesity, prevalence of type -II Diabetes Mellitus is increasing in geriatric individuals, who are generally prone to tooth loss. As a result the demand for implants in these patients is also increasing and planning implants has been a challenge to present day dentists. Diabetes Mellitus causes impaired metabolism in general, especially bone metabolism resulting in impaired Osseointegration and poor wound healing. Growing demand of implants in Type II DM patients has initiated research towards implants survival rates. Extensive research till now states - poorly controlled diabetic patients have higher implant failure rates, where as Diabetic patients with controlled blood glucose levels respond to implants in similar way as healthy patients. The present article is one such trail to confirm that type II Diabetes Mellitus is no more contra-indication for Implants till Blood glucose levels are controlled to normal levels. Key words: Type-II Diabetes Mellitus; Two-piece implant; Delayed loading;

scholarly journals Do SGLT2 Inhibitors Improve Cardio-Renal Outcomes in Patients With Type II Diabetes Mellitus: A Systematic Review

Cureus ◽  
2021 ◽  
Author(s):  
Sahithi Reddy Kalluri ◽  
Tinaz H Bhutta ◽  
Hanan Hannoodee ◽  
Mahmoud Al Khalili ◽  
Nyein Wint Yee Theik ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Sglt2 Inhibitors ◽  
Type Ii ◽  
Renal Outcomes

scholarly journals Comparative study of safety and efficacy profile of repaglinide and voglibose on targeting post prandial hyperglycemia in patients with newly diagnosed type II diabetes mellitus

2018 ◽  
Vol 7 (12) ◽  
pp. 2325
Author(s):  
Jyoti Bobde ◽  
Rajesh Kadam ◽  
Deepak Bhosle
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Treatment Strategies ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Newly Diagnosed ◽  
Open Label ◽  
Glucose Levels ◽  
Parallel Group ◽  
Glycemic Indices

Background: In India the number of people with diabetes is increasing day-by-day. Due to a sole “Asian Indian Phenotype,” Indians develop diabetes an era earlier and have an earlier onset of complications. Therefore, it is essential to evaluate more effective treatment strategies at an earlier stage of disease progression.Methods: The present study was prospective, open label, comparative, randomized, parallel group, single center study. Comparison of two post prandial active treatment groups over a period of 3 months. Sixty patients of either sex in the age group of 30-60years with newly diagnosed type II diabetes mellitus, with prandial blood glucose levels >180mg% and <250mg% at screening as per ADA. The effect of repaglinide and voglibose were observed on various parameters i.e. HbA1c, FBS, PBS, BMI.Results: In repaglinide group the mean change in HbA1c from baseline to 3 months was 8.05 to 7.04 (-1.01); on the other hand, in voglibose group from baseline to 3 months was 8.0 to 7.18 (-0.82). Whereas, FBS from 137.57 to 122.90 (-16.67) in repaglinide group; in voglibose group from 139.87 to 125.13 (-14.74). Repaglinide statistically highly significant than voglibose group in improving glycemic indices.Conclusions: Though repaglinide and voglibose were equally effective in improving glycemic indices yet repaglinide showed better results in improving HbA1c, FBG, PBS as compared with voglibose. Repaglinide had minimal side effects as compared to voglibose.

scholarly journals The Effectivity of Tomato and Guava Combination Juice and Guava Juice Administration on Blood Glucose Level in Patients with Type II Diabetes Mellitus

2019 ◽  
Author(s):  
Hasneli . ◽  
Safyanti . ◽  
Ainil Mardhiyah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Health Center ◽  
Type Ii Diabetes ◽  
Fasting Blood Glucose ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Type Ii ◽  
Glucose Levels ◽  
Blood Glucose Levels

This study aims to determine the effectivity of tomato and guava juice combination with guava juice on blood glucose levels of patients with type II diabetes mellitus in the work area of Kuranji Padang Health Center in 2019. This quasi-experimental study used a pretest-posttest design with a control group. The population of this study was all patients with type II diabetes mellitus in the working area of Kuranji Health Center, Padang City. Sampling is done by purposive sampling. The number of samples was 24 people, divided into treatment groups and a control group. The data obtained were analyzed by two different dependent tests and an independent t-test. The results of statistical tests showed that there were significant differences between the average decrease in fasting blood glucose levels of respondents who were given tomato and guava combination juice with respondents who were given guava juice (p = 0,026). People with diabetes mellitus are expected to consume tomato and guava combination juice as a form of complementary therapy.

scholarly journals Yoga Practice for the Management of Type II Diabetes Mellitus in Adults: A systematic Review

2010 ◽  
Vol 7 (4) ◽  
pp. 399-408 ◽  
Author(s):  
Badr Aljasir ◽  
Maggie Bryson ◽  
Bandar Al-shehri
Keyword(s):  
Systematic Review ◽  
Type Ii Diabetes ◽  
Grey Literature ◽  
Type Ii Diabetes Mellitus ◽  
Diabetes Type ◽  
Type Ii ◽  
Yoga Practice ◽  
Short Term ◽  
Diabetes Type Ii ◽  
Patients With Diabetes

The effect of practicing yoga for the management of type II Diabetes was assessed in this systematic review through searching related electronic databases and the grey literature to the end of May 2007 using Ovid. All randomized controlled clinical trials (RCTs) comparing yoga practice with other type of intervention or with regular practice or both, were included regardless of language or type of publication. Each study was assessed for quality by two independent reviewers. Mean difference was used for summarizing the effect of each study outcomes with 95% confidence intervals. Pooling of the studies did not take place due to the wide clinical variation between the studies. Publication bias was assessed by statistical methods. Five trials with 363 participants met the inclusion criteria with medium to high risk of bias and different intervention characteristics. The studies’ results show improvement in outcomes among patients with diabetes type II. These improvements were mainly among short term or immediate diabetes outcomes and not all were statistically significant. The results were inconclusive and not significant for the long-term outcomes. No adverse effects were reported in any of the included studies. Short-term benefits for patients with diabetes may be achieved from practicing yoga. Further research is needed in this area. Factors like quality of the trials and other methodological issues should be improved by large randomized control trials with allocation concealment to assess the effectiveness of yoga on diabetes type II. A definitive recommendation for physicians to encourage their patients to practice yoga cannot be reached at present.

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