scholarly journals Comparative study of safety and efficacy profile of repaglinide and voglibose on targeting post prandial hyperglycemia in patients with newly diagnosed type II diabetes mellitus

2018 ◽  
Vol 7 (12) ◽  
pp. 2325
Author(s):  
Jyoti Bobde ◽  
Rajesh Kadam ◽  
Deepak Bhosle
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Treatment Strategies ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Newly Diagnosed ◽  
Open Label ◽  
Glucose Levels ◽  
Parallel Group ◽  
Glycemic Indices

Background: In India the number of people with diabetes is increasing day-by-day. Due to a sole “Asian Indian Phenotype,” Indians develop diabetes an era earlier and have an earlier onset of complications. Therefore, it is essential to evaluate more effective treatment strategies at an earlier stage of disease progression.Methods: The present study was prospective, open label, comparative, randomized, parallel group, single center study. Comparison of two post prandial active treatment groups over a period of 3 months. Sixty patients of either sex in the age group of 30-60years with newly diagnosed type II diabetes mellitus, with prandial blood glucose levels >180mg% and <250mg% at screening as per ADA. The effect of repaglinide and voglibose were observed on various parameters i.e. HbA1c, FBS, PBS, BMI.Results: In repaglinide group the mean change in HbA1c from baseline to 3 months was 8.05 to 7.04 (-1.01); on the other hand, in voglibose group from baseline to 3 months was 8.0 to 7.18 (-0.82). Whereas, FBS from 137.57 to 122.90 (-16.67) in repaglinide group; in voglibose group from 139.87 to 125.13 (-14.74). Repaglinide statistically highly significant than voglibose group in improving glycemic indices.Conclusions: Though repaglinide and voglibose were equally effective in improving glycemic indices yet repaglinide showed better results in improving HbA1c, FBG, PBS as compared with voglibose. Repaglinide had minimal side effects as compared to voglibose.

scholarly journals Newly diagnosed type II diabetes mellitus presenting with localized itch

2020 ◽  
Vol 8 (5) ◽  
pp. 1878
Author(s):  
Talib Mearza ◽  
Wesam Abou Amer ◽  
Maryam Al Jaber
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Dietary Intake ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Newly Diagnosed ◽  
Cutaneous Manifestations ◽  
Sugar Levels

Type II diabetes is caused by insulin resistance resulting in high blood sugar levels. Although the typical symptoms of diabetes are described as polyuria, polydipsia and fatigue as many as 60% of newly diagnosed patients with type II diabetes are asymptomatic. Here authors present a case of a 39-year-old male patient who presented with localized pruritus affecting the medial aspects of his forearms and upper legs as the sole symptom of newly diagnosed type II diabetes mellitus. The itch symptom markedly improved on significantly reducing his dietary intake of sugars and with the use of metformin. Authors hope to alert clinicians to consider the possibility of underlying diabetes in such presentations to enable swift diagnosis and consequent treatment. It is unusual to find patients presenting with localized itch without any corresponding cutaneous manifestations as a presentation of type II diabetes.

CLINICAL STUDY TO EVALUATE EFFICACY OF NISHA AMALAKI CHURNA IN NEWLY DIAGNOSED PRAMEHA TYPE II DIABETES MELLITUS.

2021 ◽  
pp. 42-43
Author(s):  
Neena Damle
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Blood Sugar Level ◽  
Type Ii Diabetes Mellitus ◽  
Fasting Blood Sugar ◽  
Type Ii ◽  
Newly Diagnosed ◽  
Sugar Levels ◽  
Hba1c Levels

During the last few years India have maximum increase of Type II diabetes mellitus . The prevalence of type 2 diabetes mellitus is 2.4% in rural population and 11.6% in urban population[1] . In this study total 10 Subjects of newly diagnosed type II Diabetes Mellitus, who fullled below criteria were selected from D.Y. Patil Ayurvedic Hospital Nerul Navi Mumbai OPD No.1. a) HbA1c level more than 6.5% b) Fasting blood Sugar level (FBS) more than 126 mg/dL (7 mmol/L) c) 2-hour Post Prandial Blood Sugar level (PPBS) more than 200 mg/dL (11.1 mmol/L). All 10 subjects treated with Nisha Amalaki Churna 3gms BD one hour before breakfast and before dinner with warm water for three months. Data of subjective parameters and physical examination of subjects was recorded in CRF during three visits 30 days apart. For Statistical Analysis Wilcoxon matched-pairs signed-ranks test was used to assess Subjective parameters and Paired t-Test was used to compare Fasting Blood Sugar level, two hour post prandial blood sugar levels and HbA1C levels BT and AT. The study showed signicant results in most of the subjective parameters at the level of signicance (P<0.05). Nisha Amalaki Churna reduced Fasting blood sugar levels and post Prandial blood sugar levels signicantly at level of signicance p<0.01. Nisha Amalaki Churna also reduced HbA1C levels signicantly at level of signicance p<0.01.The Ayurvedic mixture Nisha Amalaki Churna was signicantly effective in newly diagnosed Type II Diabetes Mellitus subjects.

ABNORMALITIES IN PERIPHERAL NERVE FUNCTION IN NEWLY DIAGNOSED TYPE II DIABETES MELLITUS

2009 ◽  
Vol 65 (S90) ◽  
pp. 224-225
Author(s):  
J. Lehtinen ◽  
M. Uusitupa ◽  
O. Siitonen ◽  
J. Partanen ◽  
P.J. Riekkinen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerve ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Nerve Function ◽  
Newly Diagnosed ◽  
Peripheral Nerve Function

Effect of sulfonylurea therapy and plasma glucose levels on hemoglobin A1c in type II diabetes mellitus

1981 ◽  
Vol 70 (2) ◽  
pp. 373-378 ◽  
Author(s):  
T.A. Schultz ◽  
S.B. Lewis ◽  
J.L. Davis ◽  
C.R. Rost ◽  
M.M. Bliziotes
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Glucose ◽  
Type Ii Diabetes ◽  
Hemoglobin A1c ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Glucose Levels

scholarly journals Controlled Type -II Diabetes Mellitus - No More Contra-Indication for Delayed Loading of Two Piece Dental Implants - A Case Report

2019 ◽  
Vol 7 (1) ◽  
pp. 1-4
Author(s):  
Alekhya Ayalapuram
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Type Ii Diabetes ◽  
Survival Rates ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Obesity Prevalence ◽  
Glucose Levels ◽  
Blood Glucose Levels

With changing lifestyle and increasing obesity, prevalence of type -II Diabetes Mellitus is increasing in geriatric individuals, who are generally prone to tooth loss. As a result the demand for implants in these patients is also increasing and planning implants has been a challenge to present day dentists. Diabetes Mellitus causes impaired metabolism in general, especially bone metabolism resulting in impaired Osseointegration and poor wound healing. Growing demand of implants in Type II DM patients has initiated research towards implants survival rates. Extensive research till now states - poorly controlled diabetic patients have higher implant failure rates, where as Diabetic patients with controlled blood glucose levels respond to implants in similar way as healthy patients. The present article is one such trail to confirm that type II Diabetes Mellitus is no more contra-indication for Implants till Blood glucose levels are controlled to normal levels. Key words: Type-II Diabetes Mellitus; Two-piece implant; Delayed loading;

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