scholarly journals Altered Brain Glucose Consumption in Cogan’s Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Paolo Mora ◽  
Livia Ruffini ◽  
Caterina Ghetti ◽  
Stella Ghirardini ◽  
Maura Scarlattei ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Glucose Consumption ◽  
Study Groups ◽  
Control Group ◽  
Cogan’S Syndrome ◽  
Brain Glucose ◽  
Pet Ct ◽  
Cogan's Syndrome ◽  
Fdg Pet Ct ◽  
Glucose Hypometabolism

Purpose. Prospective, controlled cohort study to investigate possible alterations in brain glucose metabolism (CMRglc) in patients with Cogan’s syndrome (CS).Patients and Methods. Functional mapping of the CMRglc was obtained by quantitative molecular imaging positron emission tomography, combined with computed tomography (FDG-PET/CT). The patients were divided into three clinical groups: typical CS; atypical CS (ACS); autoimmune inner ear disease (AIED). The unmatched control group (CG) consisted of subjects requiring FDG-PET/CT for an extracranial pathology. Statistical mapping searched areas of significant glucose hypometabolism in all the affected patients (DG) and in each clinical subgroup. The results were compared with those of the CG.Results. 44 patients were enrolled (DG) and assigned to the three study groups: 8 patients to the CS group; 21 patients to the ACS group; and 15 to the AIED group. Sixteen subjects formed the CG group. Areas of significant brain glucose hypometabolism were identified in all the study groups, with the largest number and extension in the DG and CS.Conclusions. This study revealed areas of significantly altered CMRglc in patients with CS (any subform) without neurologic complains and normal conventional neuroimaging. Our results suggest that FDG-PET/CT may represent a very useful tool for the global assessment of patients with Cogan’s syndrome.

scholarly journals The Importance of FDG-PET/CT in Cogan’s Syndrome

2014 ◽  
Vol 22 (2) ◽  
pp. 74-75 ◽  
Author(s):  
Ebru Örsal ◽  
Mahir Uğur ◽  
Bedri Seven ◽  
Arif Kürşad Ayan ◽  
Fatma İçyer ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Cogan’S Syndrome ◽  
Pet Ct ◽  
Cogan's Syndrome ◽  
Fdg Pet Ct

scholarly journals Discontinuation of metformin to prevent metformin-induced high colonic FDG uptake: is 48 h sufficient?

2020 ◽  
Vol 34 (11) ◽  
pp. 833-839
Author(s):  
Nanno Schreuder ◽  
Hedwig Klarenbeek ◽  
Brian N. Vendel ◽  
Pieter L. Jager ◽  
Jos G. W. Kosterink ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Control Group ◽  
Diabetic Patients ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Group A ◽  
Clinically Significant ◽  
Fdg Pet Ct ◽  
Colon Ascendens

Abstract Objective In this retrospective, single-center observational study, we investigated whether discontinuing metformin for at least 48 h prevents metformin-induced [18F]fluorodeoxyglucose (FDG) uptake in all segments of the colon. Methods Patients with type 2 diabetes who were using metformin before undergoing an FDG PET/CT scan were included. Two groups were created: patients who discontinued metformin for less than 48 h (< 48 h group) and patients who discontinued metformin for between 48 and 72 h (≥ 48 h group). A control group comprised non-diabetic patients who were not using metformin before undergoing an FDG PET/CT. We visually scored the uptake of FDG in four segments of the colon—the ascendens, transversum, descendens, and rectosigmoid—using a four-point scale (1–4) and considered scores of 3 or 4 to be clinically significant. Results Colonic FDG uptake in the ≥ 48 h group (n = 23) was higher than uptake in the control group (n = 96) in the colon descendens [odds ratio (OR) 14.0; 95% confidence interval (CI) 4.8–40.9; p value: 0.001] and rectosigmoid (OR 11.3; 95% CI 4.0–31.9; p value: 0.001), and there was no difference in the colon ascendens and transversum. Colonic FDG uptake in the < 48 h group (n = 25) was higher than uptake in the ≥ 48 h group (n = 23) in the colon transversum (OR 4.8; 95% CI 1.3–18.5; p value: 0.022) and rectosigmoid (p value: 0.023), and there was no difference in the colon ascendens and descendens. Conclusions Discontinuing metformin for 48 h before undergoing an FDG PET/CT still gives a high uptake in the distal parts of the colon when compared with non-diabetic patients who are not using metformin. Discontinuing metformin for 48 h seems to be useful for scanning the more proximal segments of the colon.

scholarly journals Decrease in the Cortex/striatum Metabolic Ratio on 18F-FDG PET: a Biomarker of Dysimmune Encephalitis

2021 ◽  
Author(s):  
Nicolas De Leiris ◽  
Berengere Ruel ◽  
Jean Vervandier ◽  
José Boucraut ◽  
Stephan Grimaldi ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Fdg Pet ◽  
Diagnostic Value ◽  
Metabolic Ratio ◽  
Control Group ◽  
Prognostic Information ◽  
Risk Of Death ◽  
Pet Ct ◽  
Clinical Correlations ◽  
Fdg Pet Ct

Abstract Purpose: The aim was to determine the diagnostic value of the cortex/striatum metabolic ratio in 18F-FDG PET in a large cohort of patients suffering from dysimmune encephalitis (DE) and to search for clinical correlations with the course of the disease.Methods: We retrospectively collected complete clinical and paraclinical data of DE patients, including brain 18F-FDG PET/CT. Whole-brain statistical analysis was performed using SPM8 software after activity parametrization to the striatum and in comparison to healthy subjects. Conventional discriminant analysis between the DE group and controls was performed using cluster metabolic ratios. A correlation analysis between cluster metabolic ratios and clinical/paraclinical data was assessed.Results: Seventy-three patients with DE were included. In comparison to 44 controls, voxel-based statistical analysis identified one large cluster (p-voxel < 0.001 uncorrected; p-cluster<0.05, FWE corrected) of widespread decreased cortical metabolism relative to the striatum in DE patients. The mean parametrized cluster metabolic value was significantly lower for DE patients (1.06 ± 0.13) than for the control group (1.46 ± 0.08; p < 0.001). This cluster metabolic ratio correctly classified 97.4% of the individuals between patients with DE and healthy controls. Correlation analyses showed that a low cluster metabolic ratio was associated with higher risk of death (p = 0.04), the absence of autoantibodies (p = 0.05), and an increased delay between onset of symptoms and diagnostic (p = 0.01).Conclusion: The decrease in the cortex/striatal metabolic ratio has a good diagnostic performance for the differentiation of DE patients from controls and seems to provide prognostic information on the clinical course.

scholarly journals Global brain glucose uptake on 18F-FDG-PET/CT is influenced by chronic cardiovascular risk

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Austin J. Borja ◽  
Emily C. Hancin ◽  
Vincent Zhang ◽  
Benjamin Koa ◽  
Abhijit Bhattaru ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Glucose Uptake ◽  
Fdg Pet ◽  
Brain Glucose ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Global Brain

Integration of FDG-PET/CT in the Diagnostic Workup for Staphylococcus aureus Bacteremia: A Prospective Interventional Matched-cohort Study

2020 ◽  
Author(s):  
Nesrin Ghanem-Zoubi ◽  
Olga Kagna ◽  
Jawad Abu-Elhija ◽  
Mona Mustafa-Hellou ◽  
Majd Qasum ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cohort Study ◽  
Fdg Pet ◽  
Intervention Group ◽  
Control Group ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Staphylococcus Aureus Bacteremia ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Background Staphylococcus aureus bacteremia (SAB) is uniquely characterized by focal pyogenic complications that might not be apparent clinically. We investigated the benefit of adding fluorodeoxyglucose–positron emission tomography/computed tomography (FDG-PET/CT) in the workup of patients with SAB. Methods In a matched-cohort study patients with SAB (intervention group) were prospectively recruited to undergo FDG-PET/CT 7–14 days after diagnosis. Treatment was directed by FDG-PET/CT findings. Clinical outcomes were compared with a control group of patients with SAB who had not undergone FDG-PET/CT, matched by age, Charlson score, methicillin susceptibility, and survival duration to FDG-PET/CT. The primary outcome was 90-day mortality. Residual confounding was controlled through regression analyses. Results During the study period 149 patients with 151 separate episodes of SAB underwent FDG-PET/CT and were compared with 150 matched patients with 151 SAB episodes. Patients in the intervention group acquired infections more frequently in the community and had less frequently solid malignancies and more frequently high-risk SAB. Ninety-day mortality in the intervention group was significantly lower than in the control group (21/151 [13.9%] vs 43/151 [28.5%], P = .002). The difference remained significant in a subgroup analysis of patients with community-onset infections without malignancy and among patients with low-risk SAB. Controlling for other risk factors for mortality, FDG-PET/CT performance among all patients was independently associated with lower mortality (OR, .39; 95% CI, .18–.84). Patients in the intervention group had longer duration of treatment and more focus control procedures performed compared with the control group. Conclusions FDG-PET/CT in patients with SAB seems to improve survival through guidance of treatment duration and co-interventions.

Effects on 18F-FDG PET/CT Brain Glucose Metabolism in Rectal Cancer Patients Undergoing Neoadjuvant Chemotherapy

2017 ◽  
Vol 42 (12) ◽  
pp. e484-e490 ◽  
Author(s):  
Alexei M. C. Machado ◽  
Theara C. Fagundes ◽  
Arnoldo Mafra ◽  
Rodrigo G. Silva ◽  
Ana Carolina G. Castro ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Glucose Metabolism ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Fdg Pet ◽  
Brain Glucose ◽  
Pet Ct ◽  
18F Fdg ◽  
Ct Brain ◽  
Fdg Pet Ct

Increased brain glucose metabolism in chronic severe traumatic brain injury as determined by longitudinal 18F-FDG PET/CT

2018 ◽  
Vol 57 ◽  
pp. 20-25 ◽  
Author(s):  
Tomohiro Yamaki ◽  
Yoshio Uchino ◽  
Haruko Henmi ◽  
Mizuho Kamezawa ◽  
Miyoko Hayakawa ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Glucose Metabolism ◽  
Severe Traumatic Brain Injury ◽  
Fdg Pet ◽  
Brain Glucose ◽  
Brain Glucose Metabolism ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Pheochromocytoma and Paraganglioma Patients With Poor Survival Often Show Brown Adipose Tissue Activation

2020 ◽  
Vol 105 (4) ◽  
pp. 1176-1185
Author(s):  
Zahraa Abdul Sater ◽  
Abhishek Jha ◽  
Ahmed Hamimi ◽  
Adel Mandl ◽  
Iris R Hartley ◽  
...  
Keyword(s):  
Overall Survival ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Control Group ◽  
Male Body ◽  
Brown Adipose ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Context Pheochromocytomas/paragangliomas (PPGLs) are neuroendocrine tumors that can secrete norepinephrine (NE). Brown adipose tissue (BAT) activation is mediated through the action of NE on β-adrenoceptors (β-ARs). In some malignancies, BAT activation is associated with higher cancer activity. Objective To study the relationship between BAT activation and PPGL clinical outcomes. Design A retrospective case-control study that included 342 patients with PPGLs who underwent 18F-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography (18F-FDG PET/CT) imaging at the National Institutes of Health (NIH). We excluded all patients with parasympathetic tumors and those who underwent 18F-FDG PET/CT after PPGL resection. Scans of 205 patients were reviewed by 2 blinded nuclear medicine physicians; 16 patients had BAT activation on 18F-FDG PET/CT [7.80%; age 27.50 (15.00–45.50) years; 10 female/6 male; body mass index [BMI] 24.90 [19.60–25.35] kg/m2). From the remaining 189 patients, we selected 36 matched controls (age 34.4 [25.4–45.5] years; 21 female/15 male; BMI 25.0 [22.0–26.0] kg/m2). Primary Outcome Measure Overall survival. Results The presence of active BAT on 18F-FDG PET/CT was associated with decreased overall survival when compared with the control group (HRz 5.80; 95% CI, 1.05–32.05; P = 0.02). This association remained significant after adjusting for the SDHB mutation. Median plasma NE in the BAT group was higher than the control group [4.65 vs 0.55 times above the upper limit of normal; P &lt; 0.01]. There was a significant association between higher plasma NE levels and mortality in PPGLs in both groups. Conclusions Our findings suggest that the detection of BAT activity in PPGL patients is associated with higher mortality. We suggest that BAT activation could either be reflecting or contributing to a state of increased host stress that may predict poor outcome in metastatic PPGL.

scholarly journals Comparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Zi Wang ◽  
Liang Cai ◽  
Tingting Xu ◽  
Dan Tang ◽  
Lin Liu ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Type Ii Collagen ◽  
Thigh Muscle ◽  
Control Group ◽  
Late Time ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Pet Ct ◽  
Fdg Pet Ct

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. This study aims to predict the diagnostic value of 68Ga-citrate and 18F-FDG PET/CT in RA by comparing and analyzing the value of 68Ga-citrate and 18F-FDG PET/CT for diagnosing type II collagen-induced arthritis (CIA) in rats. Some CIA models were established. Normal rats were selected as the control group, and 23 days and 40 days were selected as the early and late time points of arthritis, respectively. The semiquantitative analysis of CIA rats was carried out with 68Ga-citrate PET/CT and 18F-FDG PET/CT, and the ratio of the maximum standardized uptake (SUVmax) values in the regions of interest (ROIs) of the hind foot ankle joint and thigh muscle was calculated and statistically analyzed. The distribution of CIA rats in vivo at the 68Ga-citrate 90 min time point was studied, and the ankle tissues were evaluated with hematoxylin and eosin (HE) staining. 68Ga-citrate PET/CT is obviously superior to 18F-FDG PET/CT for CIA imaging, and the statistical results show that the difference between the two examination methods is statistically significant (P<0.001). The uptake of these two radiopharmaceuticals showed the same trend in arthritis rats with different scores. The distribution of 68Ga-citrate at 90 min is consistent with the trend shown by 68Ga-citrate PET/CT. 68Ga-citrate PET/CT can reflect the inflammatory activity of affected joints in CIA rats earlier and more sensitively than 18F-FDG PET/CT, and this imaging advantage continues until the later stage of inflammation. Therefore, 68Ga-citrate PET/CT is worthy of further promotion and application in the clinical diagnosis of RA.

scholarly journals Multiparametric Monitoring of Early Response to Antiangiogenic Therapy: A Sequential Perfusion CT and PET/CT Study in a Rabbit VX2 Tumor Model

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Jung Im Kim ◽  
Hyun-Ju Lee ◽  
Young Jae Kim ◽  
Kwang Gi Kim ◽  
Kyung Won Lee ◽  
...  
Keyword(s):  
Blood Flow ◽  
Treatment Group ◽  
Fdg Pet ◽  
Antiangiogenic Therapy ◽  
Early Response ◽  
Perfusion Ct ◽  
Control Group ◽  
Pet Ct ◽  
Vx2 Tumor ◽  
Fdg Pet Ct

Objectives.To perform dual analysis of tumor perfusion and glucose metabolism using perfusion CT and FDG-PET/CT for the purpose of monitoring the early response to bevacizumab therapy in rabbit VX2 tumor models and to assess added value of FDG-PET to perfusion CT.Methods.Twenty-four VX2 carcinoma tumors implanted in bilateral back muscles of 12 rabbits were evaluated. Serial concurrent perfusion CT and FDG-PET/CT were performed before and 3, 7, and 14 days after bevacizumab therapy (treatment group) or saline infusion (control group). Perfusion CT was analyzed to calculate blood flow (BF), blood volume (BV), and permeability surface area product (PS); FDG-PET was analyzed to calculate SUVmax, SUVmean, total lesion glycolysis (TLG), entropy, and homogeneity. The flow-metabolic ratio (FMR) was also calculated and immunohistochemical analysis of microvessel density (MVD) was performed.Results.On day 14, BF and BV in the treatment group were significantly lower than in the control group. There were no significant differences in all FDG-PET-derived parameters between both groups. In the treatment group, FMR prominently decreased after therapy and was positively correlated with MVD.Conclusions.In VX2 tumors, FMR could provide further insight into the early antiangiogenic effect reflecting a mismatch in intratumor blood flow and metabolism.

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