scholarly journals Multiparametric Monitoring of Early Response to Antiangiogenic Therapy: A Sequential Perfusion CT and PET/CT Study in a Rabbit VX2 Tumor Model

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Jung Im Kim ◽  
Hyun-Ju Lee ◽  
Young Jae Kim ◽  
Kwang Gi Kim ◽  
Kyung Won Lee ◽  
...  
Keyword(s):  
Blood Flow ◽  
Treatment Group ◽  
Fdg Pet ◽  
Antiangiogenic Therapy ◽  
Early Response ◽  
Perfusion Ct ◽  
Control Group ◽  
Pet Ct ◽  
Vx2 Tumor ◽  
Fdg Pet Ct

Objectives.To perform dual analysis of tumor perfusion and glucose metabolism using perfusion CT and FDG-PET/CT for the purpose of monitoring the early response to bevacizumab therapy in rabbit VX2 tumor models and to assess added value of FDG-PET to perfusion CT.Methods.Twenty-four VX2 carcinoma tumors implanted in bilateral back muscles of 12 rabbits were evaluated. Serial concurrent perfusion CT and FDG-PET/CT were performed before and 3, 7, and 14 days after bevacizumab therapy (treatment group) or saline infusion (control group). Perfusion CT was analyzed to calculate blood flow (BF), blood volume (BV), and permeability surface area product (PS); FDG-PET was analyzed to calculate SUVmax, SUVmean, total lesion glycolysis (TLG), entropy, and homogeneity. The flow-metabolic ratio (FMR) was also calculated and immunohistochemical analysis of microvessel density (MVD) was performed.Results.On day 14, BF and BV in the treatment group were significantly lower than in the control group. There were no significant differences in all FDG-PET-derived parameters between both groups. In the treatment group, FMR prominently decreased after therapy and was positively correlated with MVD.Conclusions.In VX2 tumors, FMR could provide further insight into the early antiangiogenic effect reflecting a mismatch in intratumor blood flow and metabolism.

Integrated18F-FDG PET/CT and Perfusion CT of Primary Colorectal Cancer: Effect of Inter- and Intraobserver Agreement on Metabolic-Vascular Parameters

2012 ◽  
Vol 199 (5) ◽  
pp. 1003-1009 ◽  
Author(s):  
Vicky Goh ◽  
Manu Shastry ◽  
Alec Engledow ◽  
Robert Kozarski ◽  
Jacqui Peck ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fdg Pet ◽  
Perfusion Ct ◽  
Intraobserver Agreement ◽  
Primary Colorectal Cancer ◽  
Pet Ct ◽  
Fdg Pet Ct

Can FDG-PET/CT predict early response to neoadjuvant chemotherapy in breast cancer?

2013 ◽  
Vol 39 (12) ◽  
pp. 1358-1363 ◽  
Author(s):  
W.P. Andrade ◽  
E.N.P. Lima ◽  
C.A.B.T. Osório ◽  
M. do Socorro Maciel ◽  
G. Baiocchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Fdg Pet ◽  
Early Response ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Response To Neoadjuvant Chemotherapy

scholarly journals Multifunctional Profiling of Non-Small Cell Lung Cancer Using 18F-FDG PET/CT and Volume Perfusion CT

2012 ◽  
Vol 53 (4) ◽  
pp. 521-529 ◽  
Author(s):  
A. W. Sauter ◽  
S. Winterstein ◽  
D. Spira ◽  
J. Hetzel ◽  
M. Schulze ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Fdg Pet ◽  
Small Cell ◽  
Perfusion Ct ◽  
Small Cell Lung ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Discontinuation of metformin to prevent metformin-induced high colonic FDG uptake: is 48 h sufficient?

2020 ◽  
Vol 34 (11) ◽  
pp. 833-839
Author(s):  
Nanno Schreuder ◽  
Hedwig Klarenbeek ◽  
Brian N. Vendel ◽  
Pieter L. Jager ◽  
Jos G. W. Kosterink ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Control Group ◽  
Diabetic Patients ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Group A ◽  
Clinically Significant ◽  
Fdg Pet Ct ◽  
Colon Ascendens

Abstract Objective In this retrospective, single-center observational study, we investigated whether discontinuing metformin for at least 48 h prevents metformin-induced [18F]fluorodeoxyglucose (FDG) uptake in all segments of the colon. Methods Patients with type 2 diabetes who were using metformin before undergoing an FDG PET/CT scan were included. Two groups were created: patients who discontinued metformin for less than 48 h (< 48 h group) and patients who discontinued metformin for between 48 and 72 h (≥ 48 h group). A control group comprised non-diabetic patients who were not using metformin before undergoing an FDG PET/CT. We visually scored the uptake of FDG in four segments of the colon—the ascendens, transversum, descendens, and rectosigmoid—using a four-point scale (1–4) and considered scores of 3 or 4 to be clinically significant. Results Colonic FDG uptake in the ≥ 48 h group (n = 23) was higher than uptake in the control group (n = 96) in the colon descendens [odds ratio (OR) 14.0; 95% confidence interval (CI) 4.8–40.9; p value: 0.001] and rectosigmoid (OR 11.3; 95% CI 4.0–31.9; p value: 0.001), and there was no difference in the colon ascendens and transversum. Colonic FDG uptake in the < 48 h group (n = 25) was higher than uptake in the ≥ 48 h group (n = 23) in the colon transversum (OR 4.8; 95% CI 1.3–18.5; p value: 0.022) and rectosigmoid (p value: 0.023), and there was no difference in the colon ascendens and descendens. Conclusions Discontinuing metformin for 48 h before undergoing an FDG PET/CT still gives a high uptake in the distal parts of the colon when compared with non-diabetic patients who are not using metformin. Discontinuing metformin for 48 h seems to be useful for scanning the more proximal segments of the colon.

scholarly journals Evaluation of Breast Tumor Blood Flow with Dynamic First-Pass 18F-FDG PET/CT: Comparison with Angiogenesis Markers and Prognostic Factors

2012 ◽  
Vol 53 (4) ◽  
pp. 512-520 ◽  
Author(s):  
A. Cochet ◽  
S. Pigeonnat ◽  
B. Khoury ◽  
J.-M. Vrigneaud ◽  
C. Touzery ◽  
...  
Keyword(s):  
Blood Flow ◽  
Prognostic Factors ◽  
Fdg Pet ◽  
Breast Tumor ◽  
Tumor Blood Flow ◽  
Pet Ct ◽  
First Pass ◽  
18F Fdg ◽  
Fdg Pet Ct

18F-FDG PET/CT-related metabolic parameters and their value in early prediction of chemotherapy response in a VX2 tumor model

2010 ◽  
Vol 37 (3) ◽  
pp. 327-333 ◽  
Author(s):  
Shao-li Song ◽  
Chuang Deng ◽  
Ling-feng Wen ◽  
Jian-jun Liu ◽  
Hui Wang ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Tumor Model ◽  
Metabolic Parameters ◽  
Chemotherapy Response ◽  
Early Prediction ◽  
Pet Ct ◽  
Vx2 Tumor ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Differentiation of Malignant and Benign Pulmonary Nodules with Quantitative First-Pass 320–Detector Row Perfusion CT versus FDG PET/CT

Radiology ◽  
2011 ◽  
Vol 258 (2) ◽  
pp. 599-609 ◽  
Author(s):  
Yoshiharu Ohno ◽  
Hisanobu Koyama ◽  
Keiko Matsumoto ◽  
Yumiko Onishi ◽  
Daisuke Takenaka ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Pulmonary Nodules ◽  
Perfusion Ct ◽  
Pet Ct ◽  
First Pass ◽  
Fdg Pet Ct

scholarly journals Stereotactic Ablative Radiation Therapy for Lung Oligometastases: Predictive Parameters of Early Response by 18 FDG-PET/CT

2017 ◽  
Vol 12 (3) ◽  
pp. 547-555 ◽  
Author(s):  
Rosario Mazzola ◽  
Alba Fiorentino ◽  
Gioacchino Di Paola ◽  
Niccolò Giaj Levra ◽  
Francesco Ricchetti ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Fdg Pet ◽  
Early Response ◽  
Predictive Parameters ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Stereotactic Ablative Radiation Therapy
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