scholarly journals A Unique Case of Mycophenolate Induced Colitis after 10 Years of Use

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Abhinav Goyal ◽  
Moiz Salahuddin ◽  
Yogesh Govil
Keyword(s):  
Mycophenolate Mofetil ◽  
Lupus Nephritis ◽  
Side Effect ◽  
Flexible Sigmoidoscopy ◽  
Abdominal Distension ◽  
Watery Diarrhea ◽  
Common Side Effect ◽  
Unique Case ◽  
Gaseous Distension ◽  
History Of

A 31-year-old female with a history of lupus nephritis on Hydroxychloroquine, Prednisone, and Mycophenolate Mofetil (MMF) for 10 years presented to the hospital for ankle swelling. On day four, she started to have severe, nonbloody, watery diarrhea with abdominal distension and tenderness. Stool PCR was negative forC. difficile.CT abdomen/pelvis showed gaseous distension of the colon without any obstruction. Flexible sigmoidoscopy revealed a normal looking mucosa. Histopathology showed crypt atrophy and increased crypt apoptosis, consistent with MMF colitis. The diarrhea resolved three days after stopping MMF. Although generally well tolerated, diarrhea is a common side effect of MMF. Most cases occur in the first six months of starting MMF. This case is unique because it describes MMF colitis in lupus after more than 10 years. Thus, MMF colitis should be considered as a differential in patients taking it, regardless of the duration of use.

Quinacrine Hydrochloride-Induced Yellow Discoloration of the Skin in Children

PEDIATRICS ◽  
1982 ◽  
Vol 69 (2) ◽  
pp. 232-233
Author(s):  
Ronald J. Sokol ◽  
Philip K. Lichtenstein ◽  
Michael K. Farrell
Keyword(s):  
Case Report ◽  
Drug Administration ◽  
Side Effect ◽  
Common Side Effect ◽  
Clinical Method ◽  
The Past ◽  
Drug Of Choice ◽  
Bowel Movements ◽  
Alternative Drug ◽  
History Of

The drug of choice for treatment of giardiasis in children has changed over the past several years. Metronidazole (Flagyl) has been found to be carcinogenic in mice and mutagenic in bacteria,1 and is, therefore, no longer approved by the Food and Drug Administration for the treatment of giardiasis. Thus, quinacrine hydrochloride (Atabrine) is the recommended alternative drug for the treatment of giardiasis in children. The purpose of this report is to remind physicians of a common side effect of quinacrine hydrochloride and to call attention to a simple clinical method for its confirmation. CASE REPORT S.W., a 3-year-old white boy, had a three-week history of three to six loose, watery bowel movements per day.

Nasal vestibulitis: An MNCCTN natural history trial—Nasal vestibulitis symptoms associated with paclitaxel, docetaxel, and other chemotherapy agents.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e24086-e24086
Author(s):  
Elizabeth Jane Cathcart-Rake ◽  
David Zahrieh ◽  
Deanne s. Smith ◽  
Susan Young ◽  
Eric G. Wolfe ◽  
...  
Keyword(s):  
Natural History ◽  
Side Effect ◽  
Nasal Symptom ◽  
Smoking History ◽  
Common Side Effect ◽  
Point Scale ◽  
Nasal Symptoms ◽  
History Of ◽  
New Treatment ◽  
Taxane Chemotherapy

e24086 Background: Nasal vestibulitis has been infrequently described as a side effect of cancer-directed therapy; however, a preliminary study reported that 71% of patients undergoing taxane chemotherapy experienced nasal vestibulitis symptoms. This natural history trial describes the incidence, characteristics, and severity of nasal vestibulitis symptoms among patients undergoing paclitaxel, docetaxel, and non-taxane chemotherapy. Methods: Eligible participants who reported baseline (prior to starting chemotherapy) nasal symptoms ≤ 2 on a 10-point scale were enrolled in this trial upon initiation of a new treatment regimen, involving paclitaxel or docetaxel, or non-taxane chemotherapy. Participants completed nasal symptom logs each time they received a dose of therapy until either the regimen was stopped or four months had passed. The proportion of patients reporting new nasal symptoms was estimated within each cohort with the 95% exact confidence interval (CI). A cumulative incidence model was utilized to quantify the incidence of treatment-emergent nasal symptoms within each cohort, while controlling for age, sex, smoking history, and history of asthma or allergies. Results: Thirty-five participants received paclitaxel, 21 received docetaxel, and 25 received other types of chemotherapy. 86.4% of participants were female, mean age was 60.2 ± 11.2 years; 93.8% of participants completed 2 or more surveys. A higher percentage of participants in the paclitaxel cohort experienced new nasal vestibulitis symptoms than participants in the other two cohorts. The percentage (95% CI) of participants with nasal symptoms, for patients receiving paclitaxel, docetaxel, and non-taxane chemotherapy were 74.3% (56.7%, 87.5%), 47.6% (25.7%, 70.2%), and 44.0% (24.4%, 65.1%), respectively. Epistaxis was reported by 60% of participants in the paclitaxel cohort. Paclitaxel-receiving participants also reported nasal dryness (48.6%), scabbing (40.0%), and pain (20.0%). Nearly half of participants reported moderate symptoms (4-7 out of a 10-point scale), with 8.6% reporting symptoms as severe (8-10 on a 10-point scale). Conclusions: Nasal vestibulitis is a common side effect of chemotherapy, especially paclitaxel chemotherapy.

scholarly journals Rhopressa-induced corneal edema: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Matthew J. Chu ◽  
Michael Song ◽  
Trisa Palmares ◽  
Alice Song ◽  
Julia Song
Keyword(s):  
African American Woman ◽  
Open Angle Glaucoma ◽  
Case Reports ◽  
American Woman ◽  
Corneal Edema ◽  
Common Side Effect ◽  
Conjunctival Hyperemia ◽  
Rock Inhibitor ◽  
Unique Case ◽  
History Of

Abstract Background Rhopressa (netarsudil) has recently been added to the arsenal of treatment for open-angle glaucoma. It is an effective norepinephrine transporter and Rho-associated protein kinase (ROCK) inhibitor used to decrease intraocular pressure (IOP), with the most common side effect being conjunctival hyperemia. Case presentation We report a unique case of Rhopressa-induced corneal edema in a 79-year-old African-American woman, which resolved after discontinuation. She had a history of smoking one cigarette per day and did not consume alcohol. She had no history of corneal edema or uveitis. Conclusions Previous case reports have documented patients with Rhopressa-induced corneal edema; however, they have all had a preexisting history of corneal edema or uveitis. We believe that this is a unique case of Rhopressa-induced corneal edema in a relatively healthy eye. While Rhopressa is effective in managing glaucoma, there may be effects of treatment that are still unknown. We will discuss clinical findings of our case, along with a review of previous literature on Rhopressa and novel ROCK inhibitors. We hope that we can add to the existing body of literature and invite further investigation of Rhopressa and ROCK inhibitors and their effects on the cornea.

scholarly journals An Unconventional Diagnostic Method for Cryptosporidial Enteritis in a Healthy Host: Never Call It Quits!

2019 ◽  
Vol 13 (3) ◽  
pp. 526-531
Author(s):  
Shivantha Amarnath ◽  
Cheikh Talal El Imad ◽  
Kingsley Ebare ◽  
Hueizhi Wu ◽  
Stephen Mulrooney
Keyword(s):  
Diagnostic Method ◽  
Stool Culture ◽  
Watery Diarrhea ◽  
Peptic Ulcers ◽  
Unique Case ◽  
First Case ◽  
The Usa ◽  
History Of ◽  
Rising Incidence ◽  
Systemic Symptoms

Cryptosporidial enteritis has a rising incidence in the USA, mostly affecting immunocompromised individuals and children. It has a self-limiting course in healthy hosts. Herein, we present a unique case of a healthy middle-aged female who presented with a 1-month history of voluminous watery diarrhea and acute blood loss anemia. Cryptosporidial enteritis was diagnosed based on endoscopy with biopsy-proven evidence of 2 jejunal peptic ulcers infected with Cryptosporidiumspp. that was originally missed on routine stool culture, ova and parasite tests. The patient was successfully treated with nitazoxanide,and eradication of the protozoan was also confirmed on repeat endoscopic biopsies of the ulcer that were carried out 6 months later. To our knowledge, this is the first case to be reported in the literature with infective colonization of peptic ulcers with Cryptosporidiumspp.with consequent systemic symptoms.

scholarly journals Rituximab induced cytokine release syndrome in an MS patient: a case report

2021 ◽  
Author(s):  
Masoud Etemadifar ◽  
Mehri Salari ◽  
Mahdieh Saeri ◽  
Amirhossein Akhavan Sigari ◽  
Sara Ebrahimi
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Side Effect ◽  
Signs And Symptoms ◽  
Common Side Effect ◽  
Cytokine Release ◽  
Cytokine Release Syndrome ◽  
Relapsing Remitting ◽  
History Of ◽  
Relapsing Remitting Multiple Sclerosis

Rituximab use in multiple sclerosis has been promising. Cytokine release syndrome (CRS) is a common side effect of rituximab in patients with lymphoma. We report a case of a 44-year-old man with a history of relapsing-remitting multiple sclerosis, who presented with signs and symptoms consistent with CRS after rituximab initiation.

scholarly journals Missed opportunity of deworming a Maasai boy from nomadic family leading to life threatening intestinal obstruction

2020 ◽  
Vol 2020 (5) ◽  
Author(s):  
Jeremia J Pyuza ◽  
Alice A Andongolile ◽  
Christain E Issangya ◽  
David Msuya ◽  
James J Yahaya ◽  
...  
Keyword(s):  
Intestinal Obstruction ◽  
Abdominal Distension ◽  
Proximal Jejunum ◽  
Middle Income ◽  
Middle Income Countries ◽  
Gaseous Distension ◽  
Life Threatening ◽  
History Of ◽  
Abdominal Lavage ◽  
Fluid Levels

Abstract Mass deworming against soil-transmitted helminthiasis, including Ascaris lumbricoides (AL), is one of the largest public health interventions in low- and middle-income countries. The prevalence of A. lumbricoides in Tanzania is 6.8%. We present a 3-year-old male of a known Tanzanian nomadic tribe (Masaai tribe) with history of missed deworming, who was brought to the emergency department with a 3-day history of constipation, nonprojectile, bilious vomiting, generalized abdominal distension and pain. He was diagnosed with intestinal obstruction by the use of a plain abdominal X-ray, which revealed marked gaseous distension of the stomach and bowels without significant air-fluid levels. He was initially treated with intravenous ceftriaxone 50 mg/kg, metronidazole 15 mg/kg and acetaminophen 15 mg/kg. An explorative laparotomy was then performed. Intraoperative findings demonstrated a dense collection of A. lumbricoides worms in the gangrenous proximal jejunum and duodenum. Thorough abdominal lavage was carried out and abdomen was closed.

Abdominal Distension Following Ritual Circumcision

PEDIATRICS ◽  
1976 ◽  
Vol 57 (4) ◽  
pp. 579-579
Author(s):  
Jonathan Horwitz ◽  
Arnold Schussheim ◽  
Howard E. Scalettar
Keyword(s):  
Ad Hoc ◽  
Task Force ◽  
Abdominal Distension ◽  
Watery Diarrhea ◽  
History Of ◽  
Therapeutic Problem ◽  
Ritual Circumcision

The report of the Ad Hoc Task Force on Circumcision1 and the letter by Dr. W. Berman2 appearing in the same issue presented us with an unusual diagnostic and therapeutic problem. An 18-day-old infant was brought to us with a ten-hour history of mild, green, watery diarrhea and refusal to eat. There was no fever or vomiting, and on close questioning it was learned that he had been voiding normally. Over this period of time he refused to take any milk or liquids and it was this feature that had the parents particularly concerned.

THERAPEUTIC MANAGEMENT OF ASCITES IN SPITZ DOG IN BANGLADESH WITH A BRIEF REVIEW ON CANINE ASCITES

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
M. A. Samad
Keyword(s):  
Ascitic Fluid ◽  
Clinical Examination ◽  
Clinical Case ◽  
Abdominal Distension ◽  
Multiple Organ ◽  
Therapeutic Management ◽  
Vitamin Supplement ◽  
Case Record ◽  
Successful Recovery ◽  
History Of

Background: Ascites is one of the most important clinical syndromes, caused by multiple organ disorders, characterized by abdominal distension with accumulation of fluid of various colors and consistencies depending on the etiology that are encountered commonly in canine practice worldwide. Although it has been reported from different countries including India but it has not yet been documented from Bangladesh. Objectives: To evaluate the successful therapeutic management of a clinical case of ascites in dog supported with its brief review for its appropriate application Materials and Methods: A female Spitz dog two and half years old brought for treatment with the history of abdominal distension on 1st November 2009. Clinical examination, abdominocentesis and laboratory examination of ascitic fluid were used for the diagnosis of ascites in dog. Results: Clinical examination revealed dyspnea, discomfort, lethargy, weakness, pale mucous membrane, normal rectal temperature 103.2 0F and distended abdomen with fluid thrill on palpation. Examination of ascitic fluid revealed clear white fluid (pure transudate) which is mainly hepatic origin resulting portal hypertension and hypoproteinaemia. Treatment with restricted sodium diet, antibiotic (amoxicillin), diuretic (furosemide; Lasix, Sanofi Aventis) and vitamin B-complex and C- vitamin supplement with regular monitoring assisted in successful recovery. The recovered dog survived for next five years up to 2014 and then died due to other reasons. Conclusions: This clinical case record on canine ascites with successful treatment along with review especially on the methods of diagnosis and cause-wise treatment would certainly help the clinician for proper management of the clinical cases of canine ascites. Keywords: Ascites, Spitz dog, Diagnosis, SAAG, Therapeutic management, Brief review

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