scholarly journals Use of Scrambler Therapy in Acute Paediatric Pain: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Sabrina Congedi ◽  
Silvia Spadini ◽  
Chiara Di Pede ◽  
Martina Ometto ◽  
Tatiana Franceschi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Case Report ◽  
Side Effects ◽  
Pain Perception ◽  
Paediatric Population ◽  
Review Of The Literature ◽  
Chronic Neuropathic Pain ◽  
Relieve Pain ◽  
Scrambler Therapy ◽  
Mixed Pain

We report our clinical experience on the effect of Scrambler Therapy (ST) for a child with acute mixed pain refractory to pharmacological treatment. ST, recently proposed as an alternative treatment for chronic neuropathic pain in adults, is a noninvasive approach to relieve pain, by changing pain perception at brain level. It is safe and has no side effects. Further research is needed to assess its efficacy for acute pain and for paediatric population.

scholarly journals Can herbal medicinal products or preparations alleviate neuropathic pain in adults? A Cochrane Review summary with commentary

2020 ◽  
pp. 1-4
Author(s):  
Chiara Arienti
Keyword(s):  
Neuropathic Pain ◽  
Side Effects ◽  
Cochrane Review ◽  
Current Evidence ◽  
Chronic Neuropathic Pain ◽  
Herbal Products ◽  
Herbal Medicinal Products ◽  
Relieve Pain ◽  
Total Pain ◽  
Herbal Medicinal

BACKGROUND: Several medicines have been shown to be effective in treating neuropathic pain, but they can have damaging side effects, therefore people are now trying herbal products to help relieve pain. OBJECTIVE: The aim of the Cochrane Review was to evaluate whether herbal products/preparations have an analgesic effectiveness in neuropathic pain and whether any side effects are associated with their use. METHODS: The population addressed were adults aged ≥18 years, suffering from chronic neuropathic pain. Studies that investigated the effects of herbal products/preparations for the relief of neuropathic pain compared to any or no interventions were included. RESULTS: Included studies did not show that herbal products/preparations have reduced pain intensity of 30% or above and there was no observable reduction in the total pain score. CONCLUSIONS: There is insufficient evidence to suggest that herbal products/preparations have any efficacy in any neuropathic pain conditions. The current evidence is of very low quality resulting in serious uncertainties about the estimates of effect observed.

Long-term side effects following pneumonectomy: A case report and review of the literature

2019 ◽  
Author(s):  
BA Högerle ◽  
EL Bulut ◽  
L Klotz ◽  
F Eichhorn ◽  
M Eichhorn ◽  
...  
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Review Of The Literature

Continuous Subcutaneous Infusion of Ketorolac in Cancer Neuropathic Pain Unresponsive to Opioid and Adjuvant Drugs. A Case Report

1996 ◽  
Vol 82 (4) ◽  
pp. 413-415 ◽  
Author(s):  
Carla Ripamonti ◽  
Chiara Ticozzi ◽  
Ernesto Zecca ◽  
Carlos H. Rodriguez ◽  
Franco De Conno
Keyword(s):  
Neuropathic Pain ◽  
Case Report ◽  
Side Effects ◽  
Cancer Patient ◽  
Cancer Pain ◽  
Antidepressant Drugs ◽  
Analgesic Efficacy ◽  
Subcutaneous Infusion ◽  
Continuous Subcutaneous Infusion ◽  
Nonopioid Analgesic

Ketorolac is a new non-steroidal anti-inflammatory drug (NSAID) having a potent nonopioid analgesic activity. Administered by continuous subcutaneous infusion (CSI), its analgesic efficacy has been documented in the treatment of somatic and visceral cancer pain whilst it has been shown to be ineffective in the treatment of neuropathic pain. Here is a description of a cancer patient with neuropathic pain unresponsive to anticonvulsant or antidepressant drugs administered in association or not with oral opioids but who was successfully treated with ketorolac alone via CSI. Furthermore, the analgesia lasted over 75 days of treatment without any significant renal and gastric side effects.

scholarly journals Pulsed Radiofrequency of Stellate Ganglion for Neuropathic Pain Associated with Recurrent Pleural Leiomyosarcoma - A Case Report

2021 ◽  
Vol 0 ◽  
pp. 1-3
Author(s):  
Anand Murugesan ◽  
M. S. Raghuraman
Keyword(s):  
Neuropathic Pain ◽  
Case Report ◽  
Soft Tissue ◽  
Pain Relief ◽  
Stellate Ganglion ◽  
Soft Tissue Sarcomas ◽  
Pulsed Radiofrequency ◽  
Chronic Neuropathic Pain ◽  
Provide Pain Relief

Pleural leiomyosarcomas are rare soft-tissue sarcomas. Neuropathic pain associated with such tumours can be quite debilitating. We present the case of a 62-year-old woman with chronic neuropathic pain refractory to pharmacologic interventions in association with recurrent pleural leiomyosarcoma. Pulsed radio-frequency of the stellate ganglion was performed after due consideration and planning as a palliative measure to provide pain relief. The patient was discharged the same day with pain score 0/10 and followed up for 3 years. The unique features of this case report are: (1) Different approach of the treatment modality and (2) longer follow-up.

A Review of Scrambler Therapy for Chronic Neuropathic Pain

2016 ◽  
Vol 5 (5) ◽  
Author(s):  
Alexandra M Lesenskyj ◽  
Christina R Maxwell ◽  
Shannon Brown ◽  
Ricardo A Cruciani
Keyword(s):  
Neuropathic Pain ◽  
Chronic Neuropathic Pain ◽  
Scrambler Therapy

scholarly journals Peripheral straightjacket (α2δ Ca 2+ channel subunit) expression is required for neuropathic sensitization in Drosophila

2019 ◽  
Vol 374 (1785) ◽  
pp. 20190287 ◽  
Author(s):  
Thang M. Khuong ◽  
Zina Hamoudi ◽  
John Manion ◽  
Lipin Loo ◽  
Arjun Muralidharan ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Pain Perception ◽  
Analgesic Drug ◽  
Chronic Neuropathic Pain ◽  
Thermal Pain ◽  
Subunit Expression ◽  
Central Inhibition ◽  
Maladaptive Response

Nerve injury leads to devastating and often untreatable neuropathic pain. While acute noxious sensation (nociception) is a crucial survival mechanism and is conserved across phyla, chronic neuropathic pain is considered a maladaptive response owing to its devastating impact on a patient's quality of life. We have recently shown that a neuropathic pain-like response occurs in adult Drosophila . However, the mechanisms underlying this phenomenon are largely unknown. Previous studies have shown that the α2δ peripheral calcium channel subunit straightjacket ( stj ) is a conserved factor required for thermal pain perception. We demonstrate here that stj is required in peripheral ppk+ sensory neurons for acute thermal responses and that it mediates nociceptive hypersensitivity in an adult Drosophila model of neuropathic pain-like disease. Given that calcium channels are the main targets of gabapentinoids (pregabalin and gabapentin), we assessed if these drugs can alleviate nociceptive hypersensitivity. Our findings suggest that gabapentinoids may prevent nociceptive hypersensitivity by preserving central inhibition after nerve injury. Together, our data further highlight the similarity of some mechanisms for pain-like conditions across phyla and validates the scientific use of Drosophila neuropathic sensitization models for analgesic drug discovery. This article is part of the Theo Murphy meeting issue ‘Evolution of mechanisms and behaviour important for pain’.

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