scholarly journals Corrigendum to “Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation”

2016 ◽  
Vol 2016 ◽  
pp. 1-2
Author(s):  
Ha Thi Ngo ◽  
Ragna Bogen Hetland ◽  
Unni Cecilie Nygaard ◽  
Inger-Lise Steffensen
Keyword(s):  
Mouse Model ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Glucose Regulation ◽  
Intestinal Tumorigenesis ◽  
Diet Induced Obesity ◽  
Intestinal Neoplasia ◽  
Double Mutant Mouse

scholarly journals Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation

2015 ◽  
Vol 2015 ◽  
pp. 1-21 ◽  
Author(s):  
Ha Thi Ngo ◽  
Ragna Bogen Hetland ◽  
Unni Cecilie Nygaard ◽  
Inger-Lise Steffensen
Keyword(s):  
Glucose Regulation ◽  
Wild Type ◽  
Intestinal Tumors ◽  
Intestinal Tumorigenesis ◽  
Diet Induced Obesity ◽  
Intestinal Neoplasia ◽  
Gene Coding ◽  
Induced Tumors ◽  
Small Intestinal ◽  
Double Mutant Mouse

We have studied how spontaneous or carcinogen-induced intestinal tumorigenesis was affected by genetic or diet-induced obesity in C57BL/6J-ApcMin/+X C57BL/6J-Lepob/+mice. Obesity was induced by theobese(ob) mutation in thelepgene coding for the hormone leptin, or by a 45% fat diet. The effects of obesity were examined on spontaneous intestinal tumors caused by themultiple intestinal neoplasia(Min) mutation in theadenomatous polyposis coli(Apc) gene and on tumors induced by the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). F1 ob/ob (homozygous mutated) mice had increased body weight (bw) and number of spontaneous and PhIP-induced small intestinal tumors (inApcMin/+mice), versus ob/wt (heterozygous mutated) and wt/wt mice (homozygous wild-type). A 45% fat diet exacerbated bw and spontaneous tumor numbers versus 10% fat, but not PhIP-induced tumors. Except for bw, ob/wt and wt/wt were not significantly different. The obesity caused hyperglucosemia and insulinemia in ob/ob mice. A 45% fat diet further increased glucose, but not insulin. Inflammation was seen as increased TNFαlevels in ob/ob mice. Thus the results implicate disturbed glucose regulation and inflammation as mechanisms involved in the association between obesity and intestinal tumorigenesis. Ob/ob mice had shorter lifespan than ob/wt and wt/wt mice.

scholarly journals Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers

Oncogene ◽  
2016 ◽  
Vol 35 (35) ◽  
pp. 4601-4610 ◽  
Author(s):  
M Tumiati ◽  
P M Munne ◽  
H Edgren ◽  
S Eldfors ◽  
A Hemmes ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Mouse Model ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Breast Cancers ◽  
Common Features ◽  
Double Mutant Mouse

Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis

DNA Repair ◽  
2012 ◽  
Vol 11 (3) ◽  
pp. 278-285 ◽  
Author(s):  
Ruth Halsne ◽  
Ying Esbensen ◽  
Wei Wang ◽  
Katja Scheffler ◽  
Rajikala Suganthan ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Dna Glycosylases ◽  
Double Mutant Mouse ◽  
Dna Mutagenesis

Improvement in survival and muscle function in an mdx/utrn−/− double mutant mouse using a human retinal dystrophin transgene

2006 ◽  
Vol 16 (3) ◽  
pp. 192-203 ◽  
Author(s):  
Roger Gaedigk ◽  
Douglas J. Law ◽  
Kathleen M. Fitzgerald-Gustafson ◽  
Steven G. McNulty ◽  
Ndona N. Nsumu ◽  
...  
Keyword(s):  
Muscle Function ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Improvement In Survival ◽  
Double Mutant Mouse

G.P.8.03 Generation of double mutant mouse for the genes dystrophin and large: A new model for neuromuscular diseases

2008 ◽  
Vol 18 (9-10) ◽  
pp. 782
Author(s):  
P.C.M. Martins ◽  
D. Ayub-Guerrieri ◽  
V.F. Lopes ◽  
P.C.G. Onofre ◽  
C.M.C. Mori ◽  
...  
Keyword(s):  
Double Mutant ◽  
Mutant Mouse ◽  
Neuromuscular Diseases ◽  
New Model ◽  
Double Mutant Mouse

scholarly journals Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

2007 ◽  
Vol 16 (20) ◽  
pp. 2377-2393 ◽  
Author(s):  
C. C. Stichel ◽  
X.-R. Zhu ◽  
V. Bader ◽  
B. Linnartz ◽  
S. Schmidt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Models ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Mitochondrial Damage ◽  
Double Mutant Mouse
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