scholarly journals Corrigendum to “Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy”

2016 ◽  
Vol 2016 ◽  
pp. 1-2
Author(s):  
Nwe Ni Than ◽  
Hannah C. Jeffery ◽  
Ye H. Oo
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Autoimmune Hepatitis ◽  
Regulatory T Cell ◽  
T Cell Therapy

scholarly journals Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Nwe Ni Than ◽  
Hannah C. Jeffery ◽  
Ye H. Oo
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Therapy ◽  
Autoimmune Hepatitis ◽  
Regulatory T Cell ◽  
Cytotoxic T Cells ◽  
Personalised Medicine ◽  
Tissue Level ◽  
Current Evidence ◽  
T Cell Therapy

Autoimmune hepatitis (AIH) is an immune mediated liver injury. The precise aetiology of AIH is still unknown but current evidence suggests both genetic and environmental factors are involved. Breakdown in peripheral self-tolerance, and impaired functions of FOXP3+regulatory T cell along with effector cell resistance to suppression at the tissue level seem to play an important role in AIH immunopathogenesis. AIH is predominantly a T lymphocytes driven disease but B lymphocytes are also involved in the immunopathology. Innate immune cells are crucial in the initial onset of disease and their response is followed by adaptive T (Th1, Th17, and cytotoxic T cells) and B cell responses evidenced by liver histology and peripheral blood serology. Standard treatment regimens involving steroid and immunosuppressive medications lead to global immune suppression requiring life-long therapy with many side effects. Biologic therapies have been attempted but duration of remission is short-lived. Future direction of diagnosis and treatment for AIH should be guided by “omics” and the immunology profile of the individual patient and clinicians should aim to deliver personalised medicine for their patients. Cell therapy such as infusion of autologous, antigen-specific, and liver-homing regulatory T cells to restore hepatic immune tolerance may soon be a potential future treatment for AIH patients.

scholarly journals Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers

Immunology ◽  
2012 ◽  
Vol 136 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Megan E. Himmel ◽  
Yu Yao ◽  
Paul C. Orban ◽  
Theodore S. Steiner ◽  
Megan K. Levings
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell ◽  
Cell Therapy ◽  
Bowel Disease ◽  
Regulatory T Cell ◽  
T Cell Therapy ◽  
Inflammatory Bowel

Taking regulatory T-cell therapy one step further

2018 ◽  
pp. 1 ◽  
Author(s):  
Antoine Sicard ◽  
Dominic A. Boardman ◽  
Megan K. Levings
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy ◽  
One Step

scholarly journals Regulatory T-cell therapy in Crohn’s disease: challenges and advances

Gut ◽  
2020 ◽  
Vol 69 (5) ◽  
pp. 942-952 ◽  
Author(s):  
Jennie N Clough ◽  
Omer S Omer ◽  
Scott Tasker ◽  
Graham M Lord ◽  
Peter M Irving
Keyword(s):  
T Cells ◽  
Crohn’S Disease ◽  
T Cell ◽  
Crohn's Disease ◽  
Regulatory T Cells ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
Critical Role ◽  
Significant Proportion ◽  
T Cell Therapy

The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T cells in immune homeostasis, with defects in number and suppressive function of regulatory T cells seen in patients with Crohn’s disease. We review the function of regulatory T cells and the pathways by which they exert immune tolerance in the intestinal mucosa. We explore the principles and challenges of manufacturing a cell therapy, and discuss clinical trial evidence to date for their safety and efficacy in human disease, with particular focus on the development of a regulatory T-cell therapy for Crohn’s disease.

scholarly journals Improving the Efficacy of Regulatory T Cell Therapy

2021 ◽  
Author(s):  
Paulien Baeten ◽  
Lauren Van Zeebroeck ◽  
Markus Kleinewietfeld ◽  
Niels Hellings ◽  
Bieke Broux
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy

Effect of in vitroexpanded CD4+CD25+Foxp3+ regulatory T cell therapy combined with lymphodepletion in murine skin allotransplantation

2010 ◽  
Vol 135 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Youn-Hee Park ◽  
Sun-Kyung Koo ◽  
Youngji Kim ◽  
Hye-Mi Kim ◽  
In-Yi Joe ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy

scholarly journals Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants

2017 ◽  
Vol 17 (11) ◽  
pp. 2945-2954 ◽  
Author(s):  
S. Chandran ◽  
Q. Tang ◽  
M. Sarwal ◽  
Z. G. Laszik ◽  
A. L. Putnam ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
Kidney Transplants ◽  
T Cell Therapy
Sign in / Sign up

Export Citation Format

Share Document