scholarly journals Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants

2017 ◽  
Vol 17 (11) ◽  
pp. 2945-2954 ◽  
Author(s):  
S. Chandran ◽  
Q. Tang ◽  
M. Sarwal ◽  
Z. G. Laszik ◽  
A. L. Putnam ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
Kidney Transplants ◽  
T Cell Therapy

scholarly journals Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers

Immunology ◽  
2012 ◽  
Vol 136 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Megan E. Himmel ◽  
Yu Yao ◽  
Paul C. Orban ◽  
Theodore S. Steiner ◽  
Megan K. Levings
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell ◽  
Cell Therapy ◽  
Bowel Disease ◽  
Regulatory T Cell ◽  
T Cell Therapy ◽  
Inflammatory Bowel

Taking regulatory T-cell therapy one step further

2018 ◽  
pp. 1 ◽  
Author(s):  
Antoine Sicard ◽  
Dominic A. Boardman ◽  
Megan K. Levings
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy ◽  
One Step

scholarly journals Regulatory T-cell therapy in Crohn’s disease: challenges and advances

Gut ◽  
2020 ◽  
Vol 69 (5) ◽  
pp. 942-952 ◽  
Author(s):  
Jennie N Clough ◽  
Omer S Omer ◽  
Scott Tasker ◽  
Graham M Lord ◽  
Peter M Irving
Keyword(s):  
T Cells ◽  
Crohn’S Disease ◽  
T Cell ◽  
Crohn's Disease ◽  
Regulatory T Cells ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
Critical Role ◽  
Significant Proportion ◽  
T Cell Therapy

The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T cells in immune homeostasis, with defects in number and suppressive function of regulatory T cells seen in patients with Crohn’s disease. We review the function of regulatory T cells and the pathways by which they exert immune tolerance in the intestinal mucosa. We explore the principles and challenges of manufacturing a cell therapy, and discuss clinical trial evidence to date for their safety and efficacy in human disease, with particular focus on the development of a regulatory T-cell therapy for Crohn’s disease.

scholarly journals Improving the Efficacy of Regulatory T Cell Therapy

2021 ◽  
Author(s):  
Paulien Baeten ◽  
Lauren Van Zeebroeck ◽  
Markus Kleinewietfeld ◽  
Niels Hellings ◽  
Bieke Broux
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy

Effect of in vitroexpanded CD4+CD25+Foxp3+ regulatory T cell therapy combined with lymphodepletion in murine skin allotransplantation

2010 ◽  
Vol 135 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Youn-Hee Park ◽  
Sun-Kyung Koo ◽  
Youngji Kim ◽  
Hye-Mi Kim ◽  
In-Yi Joe ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy

scholarly journals Past, Present, and Future of Regulatory T Cell Therapy in Transplantation and Autoimmunity

2019 ◽  
Vol 10 ◽  
Author(s):  
Marco Romano ◽  
Giorgia Fanelli ◽  
Caraugh Jane Albany ◽  
Giulio Giganti ◽  
Giovanna Lombardi
Keyword(s):  
T Cell ◽  
Cell Therapy ◽  
Regulatory T Cell ◽  
T Cell Therapy

scholarly journals Human cord blood‐derived regulatory T ‐cell therapy modulates the central and peripheral immune response after traumatic brain injury

2020 ◽  
Vol 9 (8) ◽  
pp. 903-916 ◽  
Author(s):  
Henry W. Caplan ◽  
Karthik S. Prabhakara ◽  
Akshita Kumar ◽  
Naama E. Toledano‐Furman ◽  
Cecilia Martin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Immune Response ◽  
Brain Injury ◽  
T Cell ◽  
Cell Therapy ◽  
Cord Blood ◽  
Regulatory T Cell ◽  
Human Cord Blood ◽  
T Cell Therapy ◽  
Peripheral Immune Response
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