scholarly journals The Pleiotropic Effect of Physical Exercise on Mitochondrial Dynamics in Aging Skeletal Muscle

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Elena Barbieri ◽  
Deborah Agostini ◽  
Emanuela Polidori ◽  
Lucia Potenza ◽  
Michele Guescini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Physical Exercise ◽  
Mitochondrial Dynamics ◽  
Well Being ◽  
Pleiotropic Effect ◽  
Cardiovascular Fitness ◽  
Skeletal Muscle Mitochondria ◽  
Muscle Adaptations ◽  
And Function

Decline in human muscle mass and strength (sarcopenia) is one of the principal hallmarks of the aging process. Regular physical exercise and training programs are certain powerful stimuli to attenuate the physiological skeletal muscle alterations occurring during aging and contribute to promote health and well-being. Although the series of events that led to these muscle adaptations are poorly understood, the mechanisms that regulate these processes involve the “quality” of skeletal muscle mitochondria. Aerobic/endurance exercise helps to maintain and improve cardiovascular fitness and respiratory function, whereas strength/resistance-exercise programs increase muscle strength, power development, and function. Due to the different effect of both exercises in improving mitochondrial content and quality, in terms of biogenesis, dynamics, turnover, and genotype, combined physical activity programs should be individually prescribed to maximize the antiaging effects of exercise.

scholarly journals The Pleiotropic Effect of Physical Exercise on Mitochondrial Dynamics in Aging Skeletal Muscle

2017 ◽  
pp. 147-182
Author(s):  
Elena Barbieri ◽  
Deborah Agostini ◽  
Emanuela Polidori ◽  
Lucia Potenza ◽  
Michele Guescini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Physical Exercise ◽  
Mitochondrial Dynamics ◽  
Pleiotropic Effect

scholarly journals The Pleiotropic Effect of Physical Exercise on Mitochondrial Dynamics in Aging Skeletal Muscle

2016 ◽  
pp. 147-182
Author(s):  
Elena Barbieri ◽  
Deborah Agostini ◽  
Emanuela Polidori ◽  
Lucia Potenza ◽  
Michele Guescini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Physical Exercise ◽  
Mitochondrial Dynamics ◽  
Pleiotropic Effect

scholarly journals FREE TRANSPORTATION SERVICE RECIPIENTS MAY HAVE BETTER QUALITY OF LIFE BUT STILL LACK IN IMPROVING HEALTH

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S175-S176
Author(s):  
Machiko R Tomita
Keyword(s):  
Quality Of Life ◽  
Well Being ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Grocery Stores ◽  
Cross Sectional ◽  
Transportation Services ◽  
Transportation Service ◽  
And Function

Abstract This study aimed to determine if service recipients (SRs) of free transportation services experience better quality of life, health, and function compared to pre-service recipients (PSRs). We conducted a cross-sectional study using personal interviews with 43 PSRs and 30 SRs belonged to a volunteer organization. Outcome measures were Older People’s Quality of Life (QoL), Center for Epidemiology Study-Depression, and Instrumental Activities of Daily Living (IADL). Total sample (N=73) had a mean age of 78.5 years and mostly female (86.3%). The majority of PSRs wanted to go to Drs’ offices (74.4%) and Grocery stores (60.5%), followed by Drug stores (44.2%), when the service becomes available. The figures were substantially smaller among SR (40.0%, 30%, and 13.3%, respectively). In PSRs, 67.4% expected to improve health once they start receiving the service, and 70. 0% of SRs said it did with the service. Using independent t-tests, SRs were significantly better in depression (p<.001), IADL (p=0.29) and most QoL items (life overall, social relationship, home and neighborhood, psychological and emotional well-being and leisure and activities; p=.047-p=.001), except for perceived health and finance. SRs (100%) were very satisfied with the service and drivers, but 80% of SRs said they wished to use more driving services than the allowable four times per month maximum. This limitation was due to the insufficient number of volunteers compared to a large number of people in need. Availability of more volunteer drivers will likely improve SRs health. Effective approaches to increase the number of driving volunteers are necessary.

A Convenient Truth?

2021 ◽  
pp. 9-41
Author(s):  
Peter Railton
Keyword(s):  
Climate Change ◽  
Quality Of Life ◽  
Political Behavior ◽  
Well Being ◽  
Developed Countries ◽  
Subjective Well Being ◽  
History Of ◽  
And Function ◽  
The Sacrifice

Justice would appear to require that those who are the principal beneficiaries of a history of economic and political behavior that has produced dramatic climate change bear a correspondingly large share of the costs of getting it under control. Yet a widespread material ideology of happiness suggests that this would require sacrificing “quality of life” in the most-developed countries—hardly a popular program. However, an empirically-grounded understanding of the nature and function of “subjective well-being”, and of the factors that most influence it, challenges this ideology and suggests instead that well-being in more-developed as well as less-developed societies could be improved consistently with sustainable resource-utilization. If right, this could refocus debates over climate change from the sacrifice of “quality of life” to the enhancement and more equitable distribution of well-being within a framework of sustainable relations with one another and with the rest of nature.

scholarly journals The Effectiveness of Combining Visual Art Activities and Physical Exercise for Older Adults on Well-Being or Quality of Life and Mood: A Scoping Review

2017 ◽  
Vol 38 (12) ◽  
pp. 1784-1804 ◽  
Author(s):  
Roswiyani Roswiyani ◽  
Linda Kwakkenbos ◽  
Jan Spijker ◽  
Cilia L.M. Witteman
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Physical Exercise ◽  
Visual Art ◽  
Low Cost ◽  
Well Being ◽  
Small Sample ◽  
Art Activities ◽  
Small Sample Sizes

Visual art activities and physical exercise are both low-intensity and low-cost interventions. The present study aims to comprehensively describe published literature on the effectiveness of a combination of these interventions on well-being or quality of life (QoL) and mood of older adults. Embase, CINAHL, Ovid Medline (R), PsycINFO, and Web of Science databases were searched for studies published between 1990 and 2015 that evaluated interventions combining visual art therapy and exercise for people aged 50 years or older with at least one resultant well-being or QoL or mood outcome. We found 10 studies utilizing different combination programs and outcome measures, and most had small sample sizes. Seventy percent of the studies reported that combining both interventions was effective in improving well-being or QoL and mood in older adults. Future studies are, however, requisite to investigate whether in the respective population such a combination is more effective than either of the interventions alone.

A Study on Training of Contemporary College Student Everyday Sports Ability

2014 ◽  
Vol 971-973 ◽  
pp. 2509-2512
Author(s):  
Yan Long Che
Keyword(s):  
College Students ◽  
College Student ◽  
Physical Education ◽  
Physical Exercise ◽  
Everyday Life ◽  
And Function ◽  
Meaning And Function

Focusing on the training of contemporary college students' everyday sports ability, this paper analyzes the meaning and function of everyday sports and discusses measures for training contemporary college students' everyday sports ability. The research believes everyday sport is a good way to change unhealthy habits in college students' life, train contemporary college students of the awareness of lifelong physical exercise, strengthen their will and the ability to overcome difficulties so as to improve the overall quality of the whole nation. It is hoped that sports can become a part of everyday life and everyday sports can become an indispensable part in college physical education.

scholarly journals The Value of Nurses’ Codes: European nurses’ views

2006 ◽  
Vol 13 (4) ◽  
pp. 376-393 ◽  
Author(s):  
Win Tadd ◽  
Angela Clarke ◽  
Llynos Lloyd ◽  
Helena Leino-Kilpi ◽  
Camilla Strandell ◽  
...  
Keyword(s):  
Professional Practice ◽  
Code Of Ethics ◽  
Well Being ◽  
Ethical Competence ◽  
Poor Understanding ◽  
Emerging Themes ◽  
High Standards ◽  
And Function ◽  
Effective Use

Nurses are responsible for the well-being and quality of life of many people, and therefore must meet high standards of technical and ethical competence. The most common form of ethical guidance is a code of ethics/professional practice; however, little research on how codes are viewed or used in practice has been undertaken. This study, carried out in six European countries, explored nurses’ opinions of the content and function of codes and their use in nursing practice. A total of 49 focus groups involving 311 nurses were held. Purposive sampling ensured a mix of participants from a range of specialisms. Qualitative analysis enabled emerging themes to be identified on both national and comparative bases. Most participants had a poor understanding of their codes. They were unfamiliar with the content and believed they have little practical value because of extensive barriers to their effective use. In many countries nursing codes appear to be ‘paper tigers’ with little or no impact; changes are needed in the way they are developed and written, introduced in nurse education, and reinforced/implemented in clinical practice.

scholarly journals The Benefits of Physical Activity in Children and Adolescents with Epilepsy: A Systematic Review

2021 ◽  
Author(s):  
Loyane de Fátima Svierkovski ◽  
Angelica Miki Stein ◽  
Timothy Cavazzotto ◽  
Ana Carolina Paludo
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Children And Adolescents ◽  
Physical Activity Intervention ◽  
Exercise Program ◽  
Well Being ◽  
Keywords Epilepsy ◽  
Evidence Database ◽  
Positive Effect

AbstractThe aim of this study was to review the literature about the effect of physical activity intervention in children and adolescents with epilepsy. Articles were searched in the central electronic databases of MEDLINE, Embase, PsycAriticles, and CINAHL for the following keywords: “epilepsy,” “seizure,” “physical activity,” “physical exercise,” “exercise therapy,” “sport,” using the Boolean operator “AND” and “OR.” The quality of the selected articles was evaluated by the Physiotherapy Evidence Database scale. Out of the 22 articles selected, 18 did not involve intervention or did not have pre- and postresults and therefore were excluded from the study. The remaining four were studies from Canada and Korea which comprised two long-period interventions and were included in the analysis. Both programs demonstrated a positive effect of physical activity on variables related to psychological well-being and cognitive function. All the four articles demonstrated a lower score of quality. In conclusion, reviewed studies suggest that physical exercise program induces some benefits in children and adolescents with epilepsy. However, the noncontrolled trials and the varied analyses (quantitative vs. qualitative) make it difficult to establish a consensus about benefits of physical activity in epilepsy.

scholarly journals Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and Biogenesis

2021 ◽  
Vol 22 (18) ◽  
pp. 9780
Author(s):  
Mikhail V. Dubinin ◽  
Vlada S. Starinets ◽  
Eugeny Yu. Talanov ◽  
Irina B. Mikheeva ◽  
Natalia V. Belosludtseva ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Skeletal Muscles ◽  
Mitochondrial Permeability Transition ◽  
Mitochondrial Dynamics ◽  
Intraperitoneal Administration ◽  
Permeability Transition ◽  
Mdx Mice ◽  
Cyclophilin D ◽  
Calcium Dependent ◽  
Skeletal Muscle Mitochondria

Mitigation of calcium-dependent destruction of skeletal muscle mitochondria is considered as a promising adjunctive therapy in Duchenne muscular dystrophy (DMD). In this work, we study the effect of intraperitoneal administration of a non-immunosuppressive inhibitor of calcium-dependent mitochondrial permeability transition (MPT) pore alisporivir on the state of skeletal muscles and the functioning of mitochondria in dystrophin-deficient mdx mice. We show that treatment with alisporivir reduces inflammation and improves muscle function in mdx mice. These effects of alisporivir were associated with an improvement in the ultrastructure of mitochondria, normalization of respiration and oxidative phosphorylation, and a decrease in lipid peroxidation, due to suppression of MPT pore opening and an improvement in calcium homeostasis. The action of alisporivir was associated with suppression of the activity of cyclophilin D and a decrease in its expression in skeletal muscles. This was observed in both mdx mice and wild-type animals. At the same time, alisporivir suppressed mitochondrial biogenesis, assessed by the expression of Ppargc1a, and altered the dynamics of organelles, inhibiting both DRP1-mediated fission and MFN2-associated fusion of mitochondria. The article discusses the effects of alisporivir administration and cyclophilin D inhibition on mitochondrial reprogramming and networking in DMD and the consequences of this therapy on skeletal muscle health.

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