scholarly journals Unexpected Malignant Diagnosis in Colonic Biopsies: Malignant Transformation of Ovarian Mature Teratomas—Two Case Reports and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Claudia P. Rojas ◽  
Parvin Ganjei-Azar ◽  
Monica T. Garcia-Buitrago
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Case Reports ◽  
Rare Event ◽  
Cystic Teratoma ◽  
The United States ◽  
Colonic Biopsy ◽  
Malignant Diagnosis

Colorectal adenocarcinoma is the second cause of cancer-related deaths in the United States. The occurrence of squamous cell carcinoma in the colorectum is extremely unusual. Malignant transformation from mature cystic teratoma of the ovary is a rare event. The most common transformation is squamous cell carcinoma, followed by adenocarcinoma. It occurs more often in elderly patients, who usually present with advance disease. We report two unusual cases of postmenopausal women diagnosed with squamous cell carcinoma in colon biopsies. After surgical resections, the carcinoma was proven to be the result of malignant transformation of ovarian mature cystic teratomas. Since squamous cell carcinoma of the colorectum is extremely rare, the presence of squamous cell carcinoma in a colonic biopsy in a female patient should alert the clinicians to other possible primary sites, as seen in these cases.

OVARIAN MATURE CYSTIC TERATOMA WITH TRANSFORMATION INTO SQUAMOUS CELL CARCINOMA: REPORT OF TWO CASES

2021 ◽  
pp. 38-39
Author(s):  
Supriya Pradhan ◽  
Bhuvan Adhlakha ◽  
Vijay D Dombale
Keyword(s):  
Squamous Cell Carcinoma ◽  
Germ Cell ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Germ Cell Tumors ◽  
Rare Event ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma

Ovarian mature cystic teratomas are the commonest germ cell tumors of the ovary. Malignant transformation in them is a rare event and is difcult to diagnose preoperatively. Clinicians, pathologists and radiologists should always suspect this if the patient is elderly or when the cyst is large or in presence of a solid foci. Here, we discuss two cases of squamous cell carcinoma arising from a mature cystic teratoma

Squamous Cell Carcinoma Arising in a Mature Cystic Teratoma of the Ovary: A Case Report

2019 ◽  
Vol 3 (1) ◽  
pp. 60-63
Author(s):  
Poonam Lama ◽  
Jitendra Pariyar ◽  
Bimal Kumar Thapa ◽  
Neer Shobha Chitrakar ◽  
Isha Shrestha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Rare Event ◽  
Cystic Teratoma ◽  
Pelvic Mass ◽  
Signs And Symptoms ◽  
Abdominal Distension ◽  
Mature Cystic Teratoma

Mature cystic teratomas account for about 30-45% of all ovarian tumors. Malignant transformation in these tumors is a rare event, occurring in only 0.17-2% of cases, with squamous cell carcinoma being the most common type. As there are no specific signs and symptoms to suggest malignancy in dermoid cyst, it is difficult to predict, and most cases are diagnosed postoperatively. We report a 55-year-old postmenopausal lady who presented with the complaint of pain in abdomen and abdominal distension for four months and a large complex abdomino-pelvic mass evident clinically and radiologically. Final histopathology was reported as malignant transformation in mature cystic teratoma. The patient was assigned to squamous cell carcinoma of the ovary arising in a mature cystic teratoma, surgical stage IIC. In view of the poor prognosis, adjuvant chemotherapy was given.

scholarly journals Clinical analysis of 12 cases of ovarian cystic mature teratoma with malignant transformation into squamous cell carcinoma

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098154
Author(s):  
Xiangyu Wang ◽  
Wenjing Li ◽  
Yan Kong ◽  
Xiangyu Liu ◽  
Zhumei Cui
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Tumor Size ◽  
Treatment Guidelines ◽  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Clinical Analysis ◽  
Palpable Mass

Objective This study aimed to examine the clinicopathological characteristics, treatment, and prognostic factors in 12 cases of malignant transformation of mature cystic teratoma of the ovary (MCTO). Methods We performed a retrospective study of 12 patients with malignant transformation of MCTO who were admitted to the Affiliated Hospital of Qingdao University from 2003 to 2019. We examined case records, clinical parameters, and biological assessments. Results The median age of the patients was 56.5 years and seven of them were postmenopausal. The average tumor size was 18.5 cm. All patients had pelvic masses at their first hospital visit. Nine of the patients had discomfort in the lower abdomen, two presented with a lower abdominal palpable mass, and three were complicated by fever. The median follow-up time was 73 months (12‒193 months). Ten patients survived with a disease-free status and two died. Conclusions There is a low incidence of malignant transformation of MCTO, and its most common histological type is squamous cell carcinoma. Age and tumor size are important factors in malignant transformation of teratomas. While there is a lack of treatment guidelines for malignant transformation of MCTO, early diagnosis and treatment may be beneficial for these patients.

scholarly journals Squamous cell carcinoma in mature cystic teratoma of the ovary

2012 ◽  
Vol 65 (9-10) ◽  
pp. 429-431 ◽  
Author(s):  
Jelena Amidzic ◽  
Matilda Djolai ◽  
Mihaela Mocko-Kacanski ◽  
Aleksandar Gluhovic ◽  
Jelena Ilic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Rare Complication ◽  
Cystic Teratoma ◽  
Internal Surface ◽  
Cystic Mass ◽  
Mature Cystic Teratoma ◽  
Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?

2018 ◽  
Vol 28 (9) ◽  
pp. 1650-1656 ◽  
Author(s):  
Munetoshi Akazawa ◽  
Sachiko Onjo
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Clinical Characteristics ◽  
Case Series ◽  
Cystic Teratoma ◽  
The Other ◽  
The Mean

ObjectivesMalignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC.MethodsA systematic literature search of literature published from 2000 to 2017 was conducted in PubMed, Web of Science, and Scopus. We reviewed case series that included all pathological types of malignant transformation.ResultsA total of 155 cases from 15 case series, including our cases, were included. Of the cases, 90 (58%) were SCC and 65 (42%) were non-SCC, including adenocarcinoma, carcinoid tumor, thyroid carcinoma, sarcoma, adenosquamous carcinoma, melanoma, sebaceous carcinoma, oligodendroglioma, signet ring cell carcinoma, and transitional cell carcinoma, in descending order of frequency. The mean ages of patients with SCC and non-SCC were 50.5 and 48.9 years, respectively. The mean tumor sizes were 14.7 cm in SCC and 13.9 cm in non-SCC. Surgical approaches were similar. First-line chemotherapy for epithelial ovarian cancers was the most commonly used regimen in SCC and non-SCC. Overall survival did not differ significantly, showing better prognosis in stage I and poor prognosis in stages II, III, and IV. A difference in overall survival was observed among pathological types of non-SCC.ConclusionsClinical characteristics and outcomes did not differ significantly between SCC and non-SCC. However, chemotherapy regimens differed to some extent, and the possibility of difference in overall survival among pathological types of non-SCC was suggested.

scholarly journals Squamous Cell Carcinoma in Dermoid Cyst

2015 ◽  
Vol 6 (3) ◽  
pp. 133-135
Author(s):  
Lakshmidevi Muralidhar ◽  
Pramila Pandey
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Dermoid Cyst ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Reproductive Age ◽  
Age Group

ABSTRACT Mature cystic teratoma or dermoid cyst constitutes about 10 to 20% of all ovarian tumors in the reproductive age group. Malignant transformation is seen in these tumors in about 1 to 2%. Squamous cell carcinoma (SCC) constitutes about 75 to 85% of malignant transformation. Imaging characters and serum tumor markers are two important modalities to differentiate benign and malignant lesions. We are presenting a rare case of SCC arising from mature teratoma. The aim of this presentation is to stress on the significance of preoperative risk assessment of SCC in mature cystic teratoma in postmenopausal age group for optimal treatment. How to cite this article Muralidhar L, Venkatesh S, Pandey P. Squamous Cell Carcinoma in Dermoid Cyst. Int J Infertil Fetal Med 2015;6(3):133-135.

scholarly journals A Squamous Cell Carcinoma and a Malignant Fibrous Histiocytoma Developing in a Patient with a Mature Cystic Teratoma

2017 ◽  
Vol 10 (1) ◽  
pp. 98-105
Author(s):  
Ali Emre Tahaoglu ◽  
Serhat Ege ◽  
Mehmet Sait Bakir ◽  
Gülbin Saruhan ◽  
Serif Aksin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Dermoid Cyst ◽  
Malignant Transformation ◽  
Malignant Fibrous Histiocytoma ◽  
Squamous Cell ◽  
Fibrous Histiocytoma ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Benign Condition

We present a very rare case of malignant transformation of a benign mature cystic teratoma. The pathology report revealed malignant transformation of both the epithelial and sarcomatous elements of a benign dermoid cyst. To the best of our knowledge, this appears to be the third case of a malignant fibrous histiocytoma and a squamous cell carcinoma developing from a mature cystic teratoma. Malignant transformation of a dermoid cyst is usually diagnosed postmenopausally, but our patient was premenopausal. The etiology and prognosis of malignant transformation of this benign condition remain unknown.

scholarly journals A Mature Cyst Teratoma with Malignant Transformation in Squamous Cell Carcinoma Presenting Like a Sigmoid Fistula: A Case Report of a Rare Differential Diagnosis of a Giant Colonic Diverticulum

2020 ◽  
pp. 1-3
Author(s):  
Antoine Camerlo ◽  
◽  
Lysa Marie ◽  
Régis Fara ◽  
◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Colonic Diverticulum ◽  
Pelvic Mri ◽  
Rare Differential Diagnosis ◽  
Giant Colonic Diverticulum

Mature cystic teratoma is the most common form of ovarian germ cell tumor. Mature cystic teratoma is a benign tumor, mainly diagnosed in young women, with non-specific symptoms. However, the risk of malignant transformation exists (1-2%). Squamous cell carcinoma is the most frequently encountered histological form. Giant colonic diverticulum is a rare complication of diverticular disease, characterized by a diverticulum larger than 4 cm which can sometimes be confused with other digestive pathologies (appendicitis, small bowel perforation ...). We report a case of an ovarian squamous cell carcinoma arising from a mature cystic teratoma, presenting like a sigmoid fistula, with an initial doubt with the diagnosis of a giant colonic diverticulum. A 68-year-old woman was admitted for chronic hypogastric abdominal pain with a doubt concerning the diagnosis between a mature cystic teratoma and a giant colonic diverticulum. A computed tomography scan was performed revealing a perisigmoid cyst with hydro-aeric level in favor of a giant colonic diverticulum. The pelvic MRI rather suggested a left ovarian cyst, fistulated in the sigmoid colon. Finally, the colonoscopy confirmed this hypothesis with the visualization of a sigmoid fistula located 15cm from the anal margin in connection with a cavity containing hairs. Biopsies revealed a squamous cell carcinoma. After a negative extension assessment, a posterior pelvectomy was performed with pelvic and lumbo-aortic lymph node dissection. The pathological diagnosis was an ovarian pT4N1R0 squamous cell carcinoma. An adjuvant chemotherapy is still in progress.

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