scholarly journals A Squamous Cell Carcinoma and a Malignant Fibrous Histiocytoma Developing in a Patient with a Mature Cystic Teratoma

2017 ◽  
Vol 10 (1) ◽  
pp. 98-105
Author(s):  
Ali Emre Tahaoglu ◽  
Serhat Ege ◽  
Mehmet Sait Bakir ◽  
Gülbin Saruhan ◽  
Serif Aksin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Dermoid Cyst ◽  
Malignant Transformation ◽  
Malignant Fibrous Histiocytoma ◽  
Squamous Cell ◽  
Fibrous Histiocytoma ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Benign Condition

We present a very rare case of malignant transformation of a benign mature cystic teratoma. The pathology report revealed malignant transformation of both the epithelial and sarcomatous elements of a benign dermoid cyst. To the best of our knowledge, this appears to be the third case of a malignant fibrous histiocytoma and a squamous cell carcinoma developing from a mature cystic teratoma. Malignant transformation of a dermoid cyst is usually diagnosed postmenopausally, but our patient was premenopausal. The etiology and prognosis of malignant transformation of this benign condition remain unknown.

scholarly journals Squamous Cell Carcinoma in Dermoid Cyst

2015 ◽  
Vol 6 (3) ◽  
pp. 133-135
Author(s):  
Lakshmidevi Muralidhar ◽  
Pramila Pandey
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Dermoid Cyst ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Mature Teratoma ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Reproductive Age ◽  
Age Group

ABSTRACT Mature cystic teratoma or dermoid cyst constitutes about 10 to 20% of all ovarian tumors in the reproductive age group. Malignant transformation is seen in these tumors in about 1 to 2%. Squamous cell carcinoma (SCC) constitutes about 75 to 85% of malignant transformation. Imaging characters and serum tumor markers are two important modalities to differentiate benign and malignant lesions. We are presenting a rare case of SCC arising from mature teratoma. The aim of this presentation is to stress on the significance of preoperative risk assessment of SCC in mature cystic teratoma in postmenopausal age group for optimal treatment. How to cite this article Muralidhar L, Venkatesh S, Pandey P. Squamous Cell Carcinoma in Dermoid Cyst. Int J Infertil Fetal Med 2015;6(3):133-135.

scholarly journals Squamous cell carcinoma in mature cystic teratoma of the ovary

2012 ◽  
Vol 65 (9-10) ◽  
pp. 429-431 ◽  
Author(s):  
Jelena Amidzic ◽  
Matilda Djolai ◽  
Mihaela Mocko-Kacanski ◽  
Aleksandar Gluhovic ◽  
Jelena Ilic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Rare Complication ◽  
Cystic Teratoma ◽  
Internal Surface ◽  
Cystic Mass ◽  
Mature Cystic Teratoma ◽  
Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

scholarly journals A Mature Cyst Teratoma with Malignant Transformation in Squamous Cell Carcinoma Presenting Like a Sigmoid Fistula: A Case Report of a Rare Differential Diagnosis of a Giant Colonic Diverticulum

2020 ◽  
pp. 1-3
Author(s):  
Antoine Camerlo ◽  
◽  
Lysa Marie ◽  
Régis Fara ◽  
◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Colonic Diverticulum ◽  
Pelvic Mri ◽  
Rare Differential Diagnosis ◽  
Giant Colonic Diverticulum

Mature cystic teratoma is the most common form of ovarian germ cell tumor. Mature cystic teratoma is a benign tumor, mainly diagnosed in young women, with non-specific symptoms. However, the risk of malignant transformation exists (1-2%). Squamous cell carcinoma is the most frequently encountered histological form. Giant colonic diverticulum is a rare complication of diverticular disease, characterized by a diverticulum larger than 4 cm which can sometimes be confused with other digestive pathologies (appendicitis, small bowel perforation ...). We report a case of an ovarian squamous cell carcinoma arising from a mature cystic teratoma, presenting like a sigmoid fistula, with an initial doubt with the diagnosis of a giant colonic diverticulum. A 68-year-old woman was admitted for chronic hypogastric abdominal pain with a doubt concerning the diagnosis between a mature cystic teratoma and a giant colonic diverticulum. A computed tomography scan was performed revealing a perisigmoid cyst with hydro-aeric level in favor of a giant colonic diverticulum. The pelvic MRI rather suggested a left ovarian cyst, fistulated in the sigmoid colon. Finally, the colonoscopy confirmed this hypothesis with the visualization of a sigmoid fistula located 15cm from the anal margin in connection with a cavity containing hairs. Biopsies revealed a squamous cell carcinoma. After a negative extension assessment, a posterior pelvectomy was performed with pelvic and lumbo-aortic lymph node dissection. The pathological diagnosis was an ovarian pT4N1R0 squamous cell carcinoma. An adjuvant chemotherapy is still in progress.

scholarly journals Squamous cell carcinoma arising in ovarian mature cystic teratoma: report of three cases

1970 ◽  
Vol 2 (3) ◽  
pp. 248-250 ◽  
Author(s):  
R Bashyal ◽  
MC Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Postmenopausal Women ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Squamous Cell Carcinomas ◽  
Mature Cystic Teratoma ◽  
First Case

Malignant transformation of mature cystic teratoma of the ovary is rare. A wide variety of malignant tumors may arise within benign mature cystic teratoma. The most common form of malignant transformation of a mature cystic teratoma is squamous cell carcinoma. We report a series of three cases that developed squamous cell carcinoma in a benign ovarian cystic teratoma. Two of the carcinomas occurred in postmenopausal women: 51-year-old (case # 2) and 60 year-old (case # 3). The first case occurred in a 33-year-old woman. Histologically, all three cases were moderately differentiated squamous cell carcinomas and were confined to the ovaries. The aim of this study was to review our experience with this disease and to review the literature. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6032 JPN 2012; 2(3): 248-250

scholarly journals Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: A case report and review of literature

2021 ◽  
Author(s):  
Namkha Dorji ◽  
Sangay Tshering ◽  
Sonam Choden
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Rare Complication ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Review Of Literature ◽  
Thickened Wall

Introduction: Malignant transformation in mature cystic teratoma of ovary is a rare complication. Case report: A 62-year-old woman was diagnosed with squamous cell carcinoma in a mature cystic teratoma of ovary. Conclusion: Malignant transformation should be suspected in elderly woman with large mature cystic teratoma of ovary with thickened wall.

scholarly journals Malignant transformation arising in mature cystic teratoma

2016 ◽  
Vol 6 (12) ◽  
pp. 981-984 ◽  
Author(s):  
P Sherpa ◽  
R Baral ◽  
TK Kansakar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Single Case ◽  
Cystic Teratoma ◽  
Cross Sectional Study ◽  
Mature Cystic Teratoma ◽  
Cross Sectional ◽  
The Mean

Background: The prognosis of patients with malignant transformation arising within mature cystic teratoma is poor. However, preoperative diagnosis is dif cult due to its rarity. The aim of this study was to evaluate the clinical and histopathological characteristics of such malignancies. Materials and Methods: A retrospective cross sectional study on a series of cases was performed in the Department of Pathology, Patan Academy of Health Sciences, Patan Hospital, Lalitpur, Nepal from April 2011 to March 2016. Data from the histopathology database were analyzed using SPSS version 16.0. Results: Mature cystic teratoma comprised 230 cases (57.6%) out of total 399 cases of ovarian neoplasms. Malignant transformation was noted in 7 (3%) of the mature cystic teratoma. The mean age at diagnosis of patients with malignant transformation of mature cystic teratoma was 47.57 years. The size of the tumors ranged from 7-14cm. The mean diameter of tumor was 10.28cm. There was signi cant difference in age between mature cystic teratoma and malignant transformations arising within mature cystic teratoma. No signi cant association was noted in tumor size. Torsion was noted in a single case. Squamous cell carcinoma was the most common malignant tumor seen in 5 cases. The TNM stage distribution was T1aNx for 4 cases, T2aNx for one case and T3aNx for 2 cases. Conclusion: Squamous cell carcinoma is the most common malignancy arising in mature cystic teratoma. Advanced age is a signi cant risk factor for malignant transformation in mature cystic teratoma. 

scholarly journals Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

2014 ◽  
Vol 9 (1) ◽  
pp. 61-63
Author(s):  
N Gupta ◽  
T Gupta ◽  
S Jindal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Germ Cell ◽  
Cell Carcinoma ◽  
Postmenopausal Women ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Squamous Epithelium ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma

Malignant transformation of mature germ cell teratoma is rare and has been reported sporadically. Any of the constituent tissue of a teratoma has the potential to undergo malignant transformation. Squamous cell carcinoma is the most common transformation and is derived from the metaplastic squamous epithelium of teratoma. We are reporting a case of 65 years old postmenopausal women with squamous cell carcinoma arising in mature cystic cell teratoma of the ovary. DOI: http://dx.doi.org/10.3126/njog.v9i1.11191 NJOG 2014 Jan-Jun; 2(1):61-63

scholarly journals A rare case of urothelial carcinoma arising in mature cystic teratoma

2018 ◽  
Vol 7 (7) ◽  
pp. 2959
Author(s):  
Nitesh R. Maurya ◽  
Urvi C. Bhavsar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Post Menopausal ◽  
Common Malignancy ◽  
Adnexal Tumour

Mature cystic teratoma is a common benign adnexal tumour in females. It is composed of all the three germ layers (mesoderm, endoderm and ectoderm). Malignant transformation in a mature cystic teratoma of the ovary is rare, occurring in only 1-2% of cases. The most common malignancy is squamous cell carcinoma, which consists of about 80% of malignant transformations. Here we report malignant transformation of MCT in a 74year old post-menopausal female. Grossly the ovary was large cystic occupying the entire abdomen. Trial dissection was done and only 50% of the mass could be dissected due to gross adhesions. HPE reported as urothelial carcinoma in mature cystic teratoma. MCT is easily diagnosed via sonography, but malignant transformation is difficult to identify before surgery. For patients with malignant transformation, squamous cell carcinoma is the most common malignancy arising from MCT, and accounts for 80% of all cases. Other malignancies, such as adenocarcinomas, sarcomas or malignant melanomas have been reported; however, urothelial carcinoma arising from MCT is rare.

OVARIAN MATURE CYSTIC TERATOMA WITH TRANSFORMATION INTO SQUAMOUS CELL CARCINOMA: REPORT OF TWO CASES

2021 ◽  
pp. 38-39
Author(s):  
Supriya Pradhan ◽  
Bhuvan Adhlakha ◽  
Vijay D Dombale
Keyword(s):  
Squamous Cell Carcinoma ◽  
Germ Cell ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Germ Cell Tumors ◽  
Rare Event ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma

Ovarian mature cystic teratomas are the commonest germ cell tumors of the ovary. Malignant transformation in them is a rare event and is difcult to diagnose preoperatively. Clinicians, pathologists and radiologists should always suspect this if the patient is elderly or when the cyst is large or in presence of a solid foci. Here, we discuss two cases of squamous cell carcinoma arising from a mature cystic teratoma

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