scholarly journals The Nociceptive and Anti-Inflammatory Effects ofArtemisia dracunculusL. Aqueous Extract on Fructose Fed Male Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Shahraki Mohammad Reza ◽  
Mirshekari Hamideh ◽  
Samadi Zahra
Keyword(s):  
Drinking Water ◽  
Aqueous Extract ◽  
Daily Basis ◽  
Male Rats ◽  
Pain Response ◽  
Trial Period ◽  
Pain Scores ◽  
Leaf Aqueous Extract ◽  
Anti Inflammatory ◽  
Post Hoc

Aim & Objective.Artemisia dracunculusL. (Tarragon) species have been used as a traditional medicine. The present study was designed to evaluate the nociceptive and anti-inflammatory effects ofA. dracunculusL. leaf aqueous extract on fructose drinking water (FDW) in male rats.Materials & Methods. Forty-eight Wistar-albino male rats weighing 200–250 g were divided into control (C), control extract (CE), FDW, and FDWE groups (n=12). Group C did not receive any agents; Group CE did 100 mg/kgA. dracunculusL. aqueous extract on a daily basis for duration of four weeks. FDW Group received fructose drinking water (10%, weight/volume) but did not receive any agents during trial period. FDWE group received 100 mg/kgA. dracunculusL. aqueous extract during trial period. At the end of experiment, a biphasic pain response was induced following interplanetary injection of formalin (50 µL, 1%). Obtained data were analyzed using SPSS software version 17 and using ANOVA and Tukey post hoc tests. Results were expressed as mean ± SE. Statistical differences were considered significant atP<0.05.Results. Our findings revealed that acute and chronic pain scores in FDW group are significantly higher than other ones andA. dracunculusL. aqueous extract causes significant decreasing of this parameter in FDWE group (P<0.001). Moreover, IL6 and TNF values in this group were significantly decreased compared to FDW group (P<0.05).Conclusion. Results in the present study show that FDW causes the pain response score to increase and cause proinflammatory cytokines in rat model butA. dracunculusL. leaf aqueous extract improves values of these parameters.

scholarly journals Comparison between the Antioxidant and Antidiabetic Activity of Fenugreek and Buckthorn in Streptozotocin-Induced Diabetic Male Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Mohammed A. Alsieni ◽  
Haddad A. El Rabey ◽  
Abdulbasit I. Al-Sieni ◽  
Madeha N. Al-Seeni
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Negative Control ◽  
Seed Extract ◽  
Male Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Leaf Aqueous Extract

This study is aimed at comparing the antidiabetic and antioxidant potential of fenugreek and buckthorn which are commonly used in modulating diabetes in the Middle East. In this study, the antioxidant and antidiabetic activity of the aqueous extracts of the leaf and seed of fenugreek and buckthorn was tested in streptozotocin-induced diabetic male rats fed with a fat-rich diet for 8 weeks. Thirty-six male albino rats were divided into 6 groups ( n = 6 ); the 1st group was the negative control. Diabetes was induced in the other 30 rats using streptozotocin, which were then divided into 5 groups; the 2nd was the untreated positive diabetic group, the 3rd was treated with fenugreek leaf aqueous extract, the 4th was treated with the fenugreek seed aqueous extract, the 5th was treated with buckthorn leaf aqueous extract, and the 6th was treated with buckthorn seed aqueous extract. The positive control group showed an increase in blood sugar, glycated hemoglobin, liver function enzymes, lactate dehydrogenase, kidney indices, total cholesterol, triglycerides, low- and very-low-density lipoprotein, immunoglobulins, and lipid peroxidation and a decrease in high-density lipoprotein, albumin, and antioxidant activity. The histology of the liver and testes showed severe histopathological alterations. Rats of groups 4-6 that were treated with the aqueous extract of the leaf and seed extract of fenugreek and buckthorn showed improvement of all biochemical and histopathological parameters. The seed extract of fenugreek and buckthorn showed more antioxidant activity than their leaves.

scholarly journals Investigation of Anti-inflammatory Effect of Aqueous Extract of Cuminum cyminum L. by Formalin Inflammatory Model in Male Rats

2020 ◽  
Vol 4 (72) ◽  
pp. 236-246
Author(s):  
Sahar Golabi ◽  
Asma Mohammadi ◽  
Narges Chamkouri ◽  
◽  
◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Male Rats ◽  
Cuminum Cyminum ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Aqueous Extract ofPhyllanthus niruriLeaves DisplaysIn VitroAntioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Nelli Giribabu ◽  
Pasupuleti Visweswara Rao ◽  
Korla Praveen Kumar ◽  
Sekaran Muniandy ◽  
Somesula Swapna Rekha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Rat Kidney ◽  
Male Rats ◽  
Diabetic Rat ◽  
Activity Levels ◽  
Leaf Aqueous Extract ◽  
Gpx Activity

P. nirurihas been reported to possess antidiabetic and kidney protective effects. In the present study, the phytochemical constituents andin vitroantioxidant activity ofP. nirurileaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney.Results. Treatment of diabetic male rats withP. nirurileaf aqueous extract (200 and 400 mg/kg) for 28 consecutive days prevents the increase in the amount of lipid peroxidation (LPO) product, malondialdehyde (MDA), and the diminution of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity levels in the kidney of diabetic rats. The amount of LPO showed strong negative correlation with SOD, CAT, and GPx activity levels.P. nirurileaf aqueous extract exhibitsin vitroantioxidant activity with IC50slightly lower than ascorbic acid. Phytochemical screening of plant extract indicates the presence of polyphenols.Conclusion.P. nirurileaf extract protects the kidney from oxidative stress induced by diabetes.

Anti-nociceptive and anti-inflammatory effects of Withania somnifera root in fructose fed male rats

2016 ◽  
Vol 27 (4) ◽  
pp. 387-391
Author(s):  
Mohammad Reza Shahraki ◽  
Zahra Samadi Noshahr ◽  
Hassan Ahmadvand ◽  
Alireza Nakhaie
Keyword(s):  
Insulin Resistance ◽  
Drinking Water ◽  
Withania Somnifera ◽  
Resistance Index ◽  
Chronic Administration ◽  
Male Rats ◽  
Control Group ◽  
Intraplantar Injection ◽  
Insulin Resistance Index ◽  
Anti Inflammatory

Abstract Background: Insulin resistance is a metabolic disorder which affects the diabetes mellitus pathophysiology and alters the cell excitability. This study has been designed to evaluate the anti-nociceptive and anti-inflammatory effects of chronic administration of Withania somnifera root (WSR) in fructose drinking water rats. Methods: An experiment was carried out on 48 Wistar-Albino male rats, weighting 200±30 g, which were divided into six groups (n=8): control group (C), control morphine (CM), W. somnifera group (WS) which received WSR (62.5 mg/g diet), W. somnifera naloxone group (WSN) which received WSR and naloxone, fructose (F) group which received fructose drinking water and FWS group which received fructose-enriched drinking water and WSR during the trial period. A biphasic pain response was induced after intraplantar injection of formalin (50 μL, 1%). Pain behavior was measured using Dubuisson methods. The obtained data were analyzed by SPSS software V. 18, using ANOVA and Tukey test. Results were expressed as mean±SD. Statistical differences were considered significant at p<0.05. Results: The results showed that the insulin resistance index, blood sugar, insulin, IL-6, TNF-α, and acute and chronic pain score in the F group were significantly increased in comparison with the control group, but these parameters in the FWS group were significantly decreased compared with the F group (p<0.001). Conclusions: Our findings indicated that chronic oral administration of WSR has analgesic and anti-inflammatory effects in fructose drinking water rats and causes improved insulin resistance index.

Salvadora persica leaf aqueous extract attenuates hyperglycemia and hyperlipidemia in alloxan induced diabetic male rats

2018 ◽  
Vol 29 (11) ◽  
Author(s):  
Haddad El Rabey A ◽  
Fahad Almutairi M ◽  
Abdulbasit Al Sieni I ◽  
Madeha Al Seeni N ◽  
Mohammed Al Duais A ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Male Rats ◽  
Salvadora Persica ◽  
Leaf Aqueous Extract

Aqueous extract of Pedalium murex D. Royen ex L. leafy stem protects against lead induced testicular toxicity in Wistar rats

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Gerard Bessan Dossou-Agoin ◽  
Adam Gbankoto ◽  
Simon Azonbakin ◽  
Razack Osseni ◽  
Achille Yemoa ◽  
...  
Keyword(s):  
Drinking Water ◽  
Aqueous Extract ◽  
Lead Acetate ◽  
Semen Quality ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Testicular Toxicity ◽  
Male Reproductive Function ◽  
Stem Extract ◽  
Pedalium Murex

Abstract Objectives Lead exposure seriously impairs male reproductive function. The protective capacity of Pedalium murex leafy stem and fruit aqueous extracts against lead testicular toxicity is evaluated to find herbals drugs able to improve semen quality. Methods Phytochemical screening were performed according to classical methods. Twenty four male rats were divided into four groups of six rats each and received the following treatments via oral route: distilled water; 0.2% lead acetate in drinking water; 0.2% lead acetate in drinking water with 400 mg/kg P. murex aqueous leafy stem extract; 0.2% leaded water with 400 mg/kg P. murex aqueous fruit extract. Treatments were administered for 70 days. Body and reproductive organs weights, sperm parameters and testicular histological sections of each group were examined. Results Flavonoids, tannins, coumarins, alkaloids, and lignans were found in both extracts. Lead intoxication reduced sperm motility and count but increased the percentage of morphologically abnormal sperms. The germinal epithelium of seminiferous tubules histoarchitecture was disorganized by lead. The leafy stem extract was effective in reducing lead induced testicular disruption whereas fruit has not shown any beneficial effect. Conclusions P. murex leafy stem aqueous extract is effective against semen alterations caused by lead.

scholarly journals Local anti-inflammatory activity: Topical formulation containing Kalanchoe brasiliensis and Kalanchoe pinnata leaf aqueous extract

2019 ◽  
Vol 113 ◽  
pp. 108721 ◽  
Author(s):  
Edilane Rodrigues Dantas de Araújo ◽  
Juliana Félix-Silva ◽  
Jacinthia Beatriz Xavier-Santos ◽  
Júlia Morais Fernandes ◽  
Gerlane Coellho Bernardo Guerra ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Inflammatory Activity ◽  
Topical Formulation ◽  
Leaf Aqueous Extract ◽  
Kalanchoe Pinnata ◽  
Anti Inflammatory

Anti-inflammatory, antinociceptive and antipyretic properties of the aqueous extract ofClematis brachiataleaf in male rats

2010 ◽  
Vol 48 (6) ◽  
pp. 682-689 ◽  
Author(s):  
Mohammad Mostafa ◽  
Jaipal R. Appidi ◽  
Musa T. Yakubu ◽  
Anthony J. Afolayan
Keyword(s):  
Aqueous Extract ◽  
Male Rats ◽  
Anti Inflammatory

scholarly journals Evaluation of the Anti-inflammatory and Sedative Effects of Leaf Aqueous Extract of Withania somnifera (L.) Dunal (Solanaceae) in Rats and Mice

2015 ◽  
Vol 3 (10) ◽  
Author(s):  
George Jimboyeka Amabeoku ◽  
Oluchi Nneka Mbamalu ◽  
Munira Ismail ◽  
Nabeel Dudhia ◽  
Nadeem Noordien ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Withania Somnifera ◽  
Leaf Aqueous Extract ◽  
Sedative Effects ◽  
Anti Inflammatory ◽  
Rats And Mice
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