scholarly journals Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents fromPlumula nelumbinis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Xiao Ding ◽  
Ming-An Ouyang ◽  
Yuan-Shuai Shen
Keyword(s):  
Antioxidant Activity ◽  
Xanthine Oxidase ◽  
Superoxide Anion ◽  
Spectroscopic Data ◽  
Inhibitory Effect ◽  
Dpph Radical ◽  
Phenolic Constituents ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition ◽  
Hospital Acquired

Isolation of metabolites fromPlumula nelumbinisled to the discovery of eleven compounds, including six flavonoids and five phenolderivatives. Their structures have been determined on the basis of chemical and spectroscopic data. Most of them, such as compounds1,4,6,8, and10,have shown inhibitory activity against hospital-acquired methicillin-resistantStaphylococcus aureus(HA-MRSA). MICs of compound8against SA-200195 and SA-300150 were 2 μg/mL and 8 μg/mL, respectively. And the antioxidant activity of isolated compounds was determined by checking the scavenging activity against three different radicals: 2,2-diphenyl-1-picrydrazyl (DPPH) radical, hydroxyl radical (OH∙), and superoxide anion (O2∙-), as well as xanthine oxidase inhibition. All flavonoids showed strong antioxidant activity. And compound6displayed the highest inhibitory effect against xanthine oxidase with IC50value of 8.2 μg/mL.

scholarly journals Metabolites of Procyanidins From Litchi Chinensis Pericarp With Xanthine Oxidase Inhibitory Effect and Antioxidant Activity

2021 ◽  
Vol 8 ◽  
Author(s):  
Yong Sui ◽  
Jianbin Shi ◽  
Sha Cai ◽  
Tian Xiong ◽  
Bijun Xie ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Liquid Chromatography ◽  
Xanthine Oxidase ◽  
Antioxidant Activities ◽  
Shikimic Acid ◽  
Inhibitory Effect ◽  
Mass Spectrometry Analysis ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

Procyanidins from litchi pericarp (LPPC) has been evidenced to possess strong antioxidant activities in vivo that is possibly correlated with their intestinal metabolites. However, the xanthine oxidase inhibitory effect of LPPC and its metabolites was less concerned. In this study, three oligomeric procyanidins and eight metabolic phenolic acids were identified in the urine of rats administrated with LPPC by high performance liquid chromatography and liquid chromatography-mass spectrometry analysis. Data indicated that all the metabolites excreted were significantly increased by the treatment of 300 mg/kg body weight of LPPC (P < 0.05), revealing considerable 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH) and hydroxyl radicals activities of scavenging. Moreover, phenolic metabolites involving epicatechin, A-type dimer, A-type trimer, caffeic acid, and shikimic acid exhibited greater xanthine oxidase inhibition effects compared with other metabolites, with an inhibitory rate higher than 50% at the concentration 200 μg/ml. The IC50 value of these five phenols were 58.43 ± 1.86, 68.37 ± 3.50, 74.87 ± 1.30, 95.67 ± 3.82, and 96.17 ± 1.64 μg/ml, respectively. As a whole, this work suggests that the xanthine oxidase inhibition and antioxidant activity of LPPC-derived metabolites as one of the mechanisms involved in the beneficial effects of LPPC against hyperuricemia or gout.

Amplification of Antioxidant Activity and Xanthine Oxidase Inhibition of Catechin by Enzymatic Polymerization

2003 ◽  
Vol 4 (3) ◽  
pp. 469-471 ◽  
Author(s):  
Motoichi Kurisawa ◽  
Joo Eun Chung ◽  
Young Jin Kim ◽  
Hiroshi Uyama ◽  
Shiro Kobayashi
Keyword(s):  
Antioxidant Activity ◽  
Xanthine Oxidase ◽  
Enzymatic Polymerization ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

scholarly journals QSAR study of the DPPH· radical scavenging activity of coumarin derivatives and xanthine oxidase inhibition by molecular docking

2014 ◽  
Vol 12 (10) ◽  
pp. 1067-1080 ◽  
Author(s):  
Rodrigo Razo-Hernández ◽  
Kayim Pineda-Urbina ◽  
Marlene Velazco-Medel ◽  
Manuel Villanueva-García ◽  
M. Sumaya-Martínez ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Xanthine Oxidase ◽  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Chemical Hardness ◽  
Coumarin Derivatives ◽  
Dpph Radical ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

AbstractA Quantitative Structure-Activity Relationship (QSAR) of coumarins by genetic algorithms employing physicochemical, topological, lipophilic and electronic descriptors was performed. We have used experimental antioxidant activities of specific coumarin derivatives against the DPPH· radical molecule. Molecular descriptors such as Randic Path/Walk, hydrophilic factor and chemical hardness were selected to propose a mathematical model. We obtained a linear correlation with R2 = 96.65 and Q LOO2 = 93.14 values. The evaluation of the predictive ability of the model was performed by applying the Q ASYM2, $\hat r^2 $ and Δr m2 methods. Fukui functions were calculated here for coumarin derivatives in order to delve into the mechanics by which they work as primary antioxidants. We also investigated xanthine oxidase inhibition with these coumarins by molecular docking. Our results show that hydrophobic, electrostatic and hydrogen bond interactions are crucial in the inhibition of xanthine oxidase by coumarins.

scholarly journals Synthesis, Cytotoxicity, Xanthine Oxidase Inhibition, Antioxidant of New Pyrazolo{3,4 d}Pyrimidine Derivatives

2019 ◽  
Vol 16 (4(Suppl.)) ◽  
pp. 1003
Author(s):  
Khammas Et al.
Keyword(s):  
Antioxidant Activity ◽  
Physical Properties ◽  
Xanthine Oxidase ◽  
Potassium Carbonate ◽  
Pyrimidine Derivatives ◽  
Azo Compound ◽  
Dimethyl Amine ◽  
Oxidase Inhibition ◽  
Ft Ir ◽  
Xanthine Oxidase Inhibition

         Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound  ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4), Reaction of 5-(P-dimethyl amine benzene)-2-amino-1,3,4- oxadiazole in the presence of potassium carbonate anhydrous to yield new  compound (N-(2- aminoacetyl-5-(P-dimethyl amine benzene )-1,3,4-oxadiazoles-2-yl)(A30) and Azo compound (N-(5-(Azo-2-hydroxy-5-amino benzene)-1,3-Diazol-2yl)Allopurinol(A46). The structure of prepared compounds were confirmed by (FT-IR) technique and their physical properties. The synthesized compounds were tested for cytotoxicity, Xanthine oxidase inhibition, and antioxidant activity.

Antioxidant activity and xanthine oxidase inhibition activity of reductic acid: ascorbic acid analogue

2000 ◽  
Vol 10 (24) ◽  
pp. 2783-2785 ◽  
Author(s):  
Tadahiko Mashino ◽  
Yasushi Takigawa ◽  
Naomi Saito ◽  
Liquing Q Wong ◽  
Masataka Mochizuki
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Xanthine Oxidase ◽  
Inhibition Activity ◽  
Acid Analogue ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition
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