Superoxide Anion Scavenging and Xanthine Oxidase Inhibition of (+)-Catechin-Aldehyde Polycondensates. Amplification of the Antioxidant Property of (+)-Catechin by Polycondensation with Aldehydes

2004 ◽  
Vol 5 (2) ◽  
pp. 547-552 ◽  
Author(s):  
Young-Jin Kim ◽  
Joo Eun Chung ◽  
Motoichi Kurisawa ◽  
Hiroshi Uyama ◽  
Shiro Kobayashi
Keyword(s):  
Xanthine Oxidase ◽  
Superoxide Anion ◽  
Antioxidant Property ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

scholarly journals Evaluation of Anti-MRSA and Xanthine Oxidase Inhibition Activities of Phenolic Constituents fromPlumula nelumbinis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Xiao Ding ◽  
Ming-An Ouyang ◽  
Yuan-Shuai Shen
Keyword(s):  
Antioxidant Activity ◽  
Xanthine Oxidase ◽  
Superoxide Anion ◽  
Spectroscopic Data ◽  
Inhibitory Effect ◽  
Dpph Radical ◽  
Phenolic Constituents ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition ◽  
Hospital Acquired

Isolation of metabolites fromPlumula nelumbinisled to the discovery of eleven compounds, including six flavonoids and five phenolderivatives. Their structures have been determined on the basis of chemical and spectroscopic data. Most of them, such as compounds1,4,6,8, and10,have shown inhibitory activity against hospital-acquired methicillin-resistantStaphylococcus aureus(HA-MRSA). MICs of compound8against SA-200195 and SA-300150 were 2 μg/mL and 8 μg/mL, respectively. And the antioxidant activity of isolated compounds was determined by checking the scavenging activity against three different radicals: 2,2-diphenyl-1-picrydrazyl (DPPH) radical, hydroxyl radical (OH∙), and superoxide anion (O2∙-), as well as xanthine oxidase inhibition. All flavonoids showed strong antioxidant activity. And compound6displayed the highest inhibitory effect against xanthine oxidase with IC50value of 8.2 μg/mL.

Purpurogallin is a more powerful protector of kidney cells than Trolox and allopurinol

1992 ◽  
Vol 70 (8) ◽  
pp. 684-690 ◽  
Author(s):  
Ling-Hua Zeng ◽  
Tai-Wing Wu
Keyword(s):  
Xanthine Oxidase ◽  
Phase Contrast ◽  
Potent Inhibitor ◽  
Rat Kidney ◽  
Peroxyl Radicals ◽  
Kidney Cells ◽  
Tubular Epithelial Cells ◽  
Electron Microscopic ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition

Phase contrast and electron microscopic experiments demonstrated that oxyradicals generated with xanthine oxidase and hypoxanthine markedly damage rat kidney mesangial and porcine tubular epithelial cells. Purpurogallin, a phenol found in oak nutgalls, prolongs survival of the xanthine oxidase exposed renal cells three- to nine-fold longer than those without purpurogallin present. At levels equimolar to purpurogallin, either Trolox or allopurinol is less effective in delaying cell necrosis. Purpurogallin scavenges not only xanthine oxidase generated oxyradicals, but also non-enzymatically produced peroxyl radicals, more actively than equimolar levels of Trolox or allopurinol. Purpurogallin inhibits xanthine oxidase with severalfold higher potency than allopurinol and its more active metabolite oxypurinol. Therefore, purpurogallin is a stronger antioxidant than Trolox and a more potent inhibitor of xanthine oxidase than allopurinol as well as oxypurinol.Key words: purpurogallin, kidney cells, oxyradical damage, xanthine oxidase inhibition, antioxidant.

scholarly journals Optimization of the Extraction Conditions and Biological Evaluation of Dendropanax morbifera H. Lev as an Anti-Hyperuricemic Source

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3313 ◽  
Author(s):  
Seung-Sik Cho ◽  
Seung-Hui Song ◽  
Chul-Yung Choi ◽  
Kyung Park ◽  
Jung-Hyun Shim ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Ethanol Extract ◽  
Oxidase Inhibitor ◽  
Xanthine Oxidase Inhibitor ◽  
Dendropanax Morbifera ◽  
Hexane Extracts ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition ◽  
Ethanol Extracts

Dendropanax morbifera H. Levis a medicinal plant native to South Korea, East Asia, and South America. Among some 75 species, one species grows in Korea. In previous studies, D. morbifera extracts with anti-oxidant, anti-inflammatory, anti-complementary and anti-cancer activities were reported. The present study aims to investigate optimization of extraction and evaluation of anti-hyperuricemic effects of D. morbifera leaf and the phytochemicals contained therein. Ethanol and hexane extract were found to display the best xanthine oxidase inhibition among six types of solvent and water extract. The antioxidant effect of the ethanol extract was superior to that of the hexane extract. The DPPH radical scavenging effect of the ethanol and hexane extracts were 81.52 ± 1.57% and 2.69 ± 0.16. The reducing power of the ethanol and hexane extracts were 9.71 ± 0.15 and 0.89 ± 0.01 mg/g equivalent of gallic acid. Total phenols of the ethanol and hexane extracts were 6.53 ± 0.16 and 0.63 ± 0.001 mg/g equivalent of gallic acid. In addition, we compared the two marker compounds from D. morbifera, chlorogenic acid and rutin, which were determined in the ethanol extract at 0.80 ± 0.03% and 0.52 ± 0.01%, respectively. We found that the ethanol extracts showed better xanthine oxidase inhibition than hexane extracts. Especially, ethanol extracts showed higher antioxidant activity than hexane extracts. Based on these results, we selected the ethanol extract as an effective xanthine oxidase inhibitor and confirmed whether ethanol extracts showed xanthine oxidase inhibition in animal experiments. The in vivo mouse study demonstrated that ethanol extract of D. morbifera leaf at the dose of 300 mg/kg could inhibit blood/hepatic xanthine oxidase activity and this result shows that the xanthine oxidase inhibitory activity in vitro is reproduced in vivo. The present study showed that ethanol extract was optimal xanthine oxidase inhibitor which can be applied to prevent diseases related to hyperuricemia.

Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice

2020 ◽  
Author(s):  
Yoshiro Tanaka ◽  
Tomohisa Nagoshi ◽  
Akira Yoshii ◽  
Yuhei Oi ◽  
Hirotake Takahashi ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Oxidase Inhibition ◽  
Xanthine Oxidase Inhibition
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