scholarly journals Aggressive Angiomyxoma of the Bladder Neck Requiring Local Excision and Mitrofanoff Formation

2015 ◽  
Vol 2015 ◽  
pp. 1-2
Author(s):  
M. Davari ◽  
B. W. Lamb ◽  
S. Chowdhury ◽  
C. Jameson ◽  
J. D. Kelly ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Female Patient ◽  
Local Excision ◽  
Bladder Neck ◽  
Unusual Case ◽  
Surgical Excision ◽  
Aggressive Angiomyxoma ◽  
Female Pelvis ◽  
Diagnostic Challenge ◽  
Mesenchymal Tumour

Aggressive angiomyxoma is a rare mesenchymal tumour predominantly affecting the female pelvis and perineum but has also been described in males. This tumour can often present a diagnostic challenge and has a propensity for local recurrence after surgical excision. We present an unusual case of aggressive angiomyxoma arising from the bladder of a female patient which required local excision and Mitrofanoff formation.

scholarly journals Iatrogenic Inflammatory Fibrosis of Hard Palate in a 13-Year-Old Female Patient

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Shanthan Mettu ◽  
Radhika Muppa ◽  
G. Siva Prasad Reddy ◽  
Srinivas Nallanchakrava ◽  
Sri Veda Gurugubelli
Keyword(s):  
Female Patient ◽  
Hard Palate ◽  
Unusual Case ◽  
Fibrous Tissue ◽  
Surgical Excision ◽  
Inflammatory Cells ◽  
Nerve Tissue ◽  
Rare Occurrence ◽  
Reactive Process ◽  
Tooth Number

Palatal swellings are rare in children and the incidence differs from that of the adult counterparts. When the palatal swellings do arise in children, they usually are palatal abscess from periapical region, and few cases like pleomorphic adenoma in young adults have also been reported. But inflammatory fibrosis of palate in children is a rare occurrence. Inflammatory fibrosis is formation of excess fibrous connective tissue in an organ or tissue, as a reparative or reactive process. This report describes an unusual case of iatrogenic inflammatory fibrosis on the palate due to extraction of tooth number 22 in a 13-year-old female patient. The patient presented with a single large well-circumscribed oval palatal swelling that was soft, fluctuant, not fixed, and nontender. Surgical excision of the lesion was done and it was sent for histopathological assessment. The biopsy showed fibrous tissue with collagen fibers, spindle shaped fibroblasts, neovascularization, RBCs, chronic inflammatory cells, and traces of salivary gland and nerve tissue.

scholarly journals Aggressive Angiomyxoma: A Rare Tumor of Male Pelvic Cavity

2018 ◽  
Vol 31 (11) ◽  
pp. 693 ◽  
Author(s):  
Suleyman Utku Celik ◽  
Ilkin Hesimov ◽  
Burak Kutlu ◽  
Ayhan Bulent Erkek
Keyword(s):  
Unusual Case ◽  
Surgical Excision ◽  
Complete Resection ◽  
Pelvic Cavity ◽  
Interstitial Tissue ◽  
Aggressive Angiomyxoma ◽  
Soft Tissue Neoplasm ◽  
Fourth Decade ◽  
Male Patients ◽  
Slow Growing

Aggressive angiomyxoma is an uncommon, benign, slow-growing, and locally infiltrative soft tissue neoplasm which is located primarily in the genital region and pelviperineal interstitial tissue of female patient in the fourth decade of life. Its occurrence in male patients is even more unusual and commonly appears at a later age. The mainstay of treatment typically involves surgical excision with tumor-free margins, and despite complete resection, local recurrences are common. Here, an unusual case of aggressive angiomyxoma occurring in the pelvic region of a 55-year-old man and its treatment is discussed due to its rarity.

Aggressive Angiomyxoma

2012 ◽  
Vol 136 (2) ◽  
pp. 217-221 ◽  
Author(s):  
Brian J. Sutton ◽  
Jennifer Laudadio
Keyword(s):  
Local Recurrence ◽  
Progesterone Receptors ◽  
Chromosomal Translocation ◽  
Surgical Excision ◽  
Vascular Tumor ◽  
Gonadotropin Releasing Hormone ◽  
Aggressive Angiomyxoma ◽  
Estrogen And Progesterone Receptors ◽  
Myxoid Stroma ◽  
Emerging Therapy

Aggressive angiomyxoma is a rare mesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Patients often present with nonspecific symptoms which are frequently misdiagnosed with more common entities, such as a Bartholin cyst, lipoma, or hernia. Histologic examination reveals a hypocellular and highly vascular tumor with a myxoid stroma containing cytologically bland stellate or spindled cells. The tumor cells are characteristically positive for estrogen and progesterone receptors, suggesting a hormonal role in the development of the tumor. Chromosomal translocation of the 12q13-15 band involving the HMGA2 gene has been described. Surgical excision is the treatment of choice, although treatment with gonadotropin-releasing hormone agonists is an emerging therapy. Metastases are exceedingly rare, and overall, the prognosis is good.

Recurrent perineal aggressive angiomyxoma: dilemma in diagnosis and outcome of this rare disease

2021 ◽  
Vol 14 (2) ◽  
pp. e238722
Author(s):  
Nitin Paul Ambrose ◽  
Victor Vijay Coelho ◽  
Beulah Roopavathana ◽  
Suchita Chase
Keyword(s):  
Surgical Excision ◽  
Perineal Hernia ◽  
Complete Resection ◽  
Aggressive Angiomyxoma ◽  
Immunohistochemical Examination ◽  
Male Population ◽  
Mesenchymal Tumour ◽  
Diagnostic Dilemma ◽  
Perineal Region ◽  
High Chance

Aggressive angiomyxoma (AAM) is a very rare, benign, locally infiltrative mesenchymal tumour with a high chance of recurrence following surgical excision. In the male population, it is so rare that less than only 50 cases have been reported so far. We present a case of a large recurrent perineal AAM in a man who presented with swelling in the perineal region following surgical excision 3 years ago. After evaluation, the diagnostic dilemma of a possible perineal hernia or recurrence remained. Surgical exploration ruled out hernia and the tumour was excised with difficulty. Immunohistochemical examination showed tumour cells with diffuse nuclear positivity for oestrogen receptor and patchy cytoplasmic positivity for desmin (A2). Histological and immunohistochemical features confirmed the diagnosis. Being very rare, AAMs need to be considered as a differential diagnosis of pelvic/perineal tumours among males. With no standardised therapy for AAM, complete resection would be the goal of therapy.

Vulvar soft tissue tumors

2004 ◽  
Vol 14 (1) ◽  
pp. 94-99
Author(s):  
K. A. Behranwala ◽  
B. Latifaj ◽  
P. Blake ◽  
D. P. J. Barton ◽  
J. H. Shepherd ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Surgical Excision ◽  
Primary Treatment ◽  
Soft Tissue Tumors ◽  
Soft Tissue Neoplasms ◽  
Low Grade ◽  
Aggressive Angiomyxoma ◽  
Royal Marsden Hospital ◽  
Histologic Types

ObjectiveTo report our incidence of soft tissue tumors at this site and to discuss various prognostic factors.MethodsAll patients with a diagnosis of vulvar soft tissue neoplasms were studied from a prospective database at the Royal Marsden Hospital between January 1985 and July 2001.ResultsSeventeen vulvar soft tissue neoplasms (11 malignant and six benign) were treated during this period. Leiomyosarcoma (n = 5) and aggressive angiomyxoma (n = 4) were the most frequent histologic types. According to the grade, there were four G3, three G2, three G1 and could not be assessed in one patient. Local recurrence occurred in six patients with sarcoma (three with high grade and one each with intermediate, low, and undetermined grade). In this group, five patients had negative microscopic margins and one patient had positive microscopic margins on excision. All three women with low-grade sarcomas are alive without evidence of disease. Three patients with aggressive angiomyxoma also had a local recurrence.ConclusionSurgical excision is the primary treatment where possible. The grade of the tumor is an important predictor for local recurrence and outcome. Aggressive angiomyxoma is a local problem. Leiomyosarcoma and aggressive angiomyxoma are the most frequent histologic types.

scholarly journals Aggressive Angiomyxoma of the Vulva: A Bizarre Perineal Lesion

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Adamantia Zizi-Sermpetzoglou ◽  
Despoina Myoteri ◽  
Kalliroi Koulia ◽  
Vassilios Kontostolis ◽  
Hippokratis Moschouris ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Local Excision ◽  
Wide Local Excision ◽  
Reproductive Age ◽  
White Female ◽  
Aggressive Angiomyxoma ◽  
Case Presentation ◽  
Hormonal Manipulation ◽  
Myxoid Matrix ◽  
The Right

Introduction. Aggressive angiomyxoma is a rare, slowly growing, and benign tumour of mesenchymal origin, which affects women of reproductive age and is associated with a high risk of local recurrence.Case Presentation. A case of a 47-year-old white female is presented herein, with a large polypoid, gelatinous mass on the right labia majora, measuring 26 × 21 × 6 cm. Histopathologically, the lesion was composed of spindle and stellate-shaped cells embedded in a myxoid matrix. Another specific feature was the presence of variable-sized thin-walled capillaries and thick-walled vascular channels. The patient underwent wide local excision of the tumour with clear margins and developed local recurrence 18 months later.Discussion. Aggressive angiomyxoma of the vulva needs to be distinguished from benign myxoid tumors with a low risk of local recurrence as well as from malignant myxoid neoplasms. Usually wide local excision with tumour-free margins and occasionally hormonal manipulation is the treatment of choice.

scholarly journals Phosphaturie mesenchymal tumour, 'non-phosphaturic' variant: a case report and review of the literature

2021 ◽  
Vol 20 (3) ◽  
Author(s):  
Reubina Wadee ◽  
Zwelithini Linda ◽  
Abdullah Ismail
Keyword(s):  
Correct Diagnosis ◽  
Surgical Excision ◽  
Normal Serum ◽  
Histopathological Diagnosis ◽  
Diagnostic Challenge ◽  
Mesenchymal Tumour ◽  
Level Of Evidence ◽  
Tissue Mass ◽  
Normal Serum Calcium ◽  
Mesenchymal Tumours

ABSTRACT BACKGROUND: Phosphaturic mesenchymal tumours are uncommon neoplasms, usually associated with tumour-induced osteomalacia, that occur in middle-aged adults but have been reported at the extremes of age. The 'non-phosphaturic' variant is even rarer METHODS: Herein, we describe the non-phosphaturic variant in a 12-year-old male who presented to the Department of Orthopaedic Surgery with a six-month history of painful progressive swelling of his right forearm in the absence of trauma. He had no other significant symptoms RESULTS: The patient had normal serum calcium and phosphate levels on biochemical analysis. An inci-sional biopsy was performed and a histopathological diagnosis of a phosphaturic mesenchymal tumour, non-phosphaturic variant, was rendered. Six weeks later, he underwent surgical excision of a 15x15 cm soft tissue mass from his right forearm. He had an uneventful postoperative period and was discharged. He has been followed up at the outpatient department and has been free of tumour recurrence for over 18 months since his surgery with no evidence of osteomalacia and no other tumours CONCLUSION: Phosphaturic mesenchymal tumours are rare mesenchymal neoplasms and their microscopically identical counterpart without phosphaturia, known as the 'non-phosphaturic' variant, is even more uncommon and may prove a greater diagnostic challenge. While the diagnosis may be confirmed by hypophosphataemia and phosphaturia secondary to the paraneoplastic phenomenon of tumour-induced osteomalacia, there may be instances, such as with our patient, where tumour-induced osteomalacia is absent. This case underscores the importance of clinicopathological correlation together with a wide differential diagnosis required to arrive at a correct diagnosis to facilitate appropriate patient management Level of evidence: Level 5 Keywords: phosphaturic mesenchymal tumours, non-phosphaturic variant

Incidental finding of paratesticular aggressive angiomyxoma in a 72-year-old monorchid male

2019 ◽  
Vol 87 (4) ◽  
pp. 194-198
Author(s):  
Armando Serao ◽  
Donatella Tiranti ◽  
Muriel Ferraro ◽  
Rafaela Malinaric ◽  
Paola Re ◽  
...  
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Incidental Finding ◽  
Surgical Excision ◽  
Aggressive Angiomyxoma ◽  
First Line ◽  
Mesenchymal Neoplasm ◽  
The Common ◽  
Line Of Therapy

Aggressive angiomyxoma is an uncommon mesenchymal neoplasm. It arises from soft tissue of pelvis and perineum in fertile females, occurring very rarely in males. Its name emphasizes the common local recurrence and infiltrative tendency, but usually it does not metastasize. Currently, the first line of therapy is surgical excision, achieving R0 surgical margins, and radiological follow-up. This case report describes an uncommon, incidental finding of paratesticular aggressive angiomyxoma in an asymptomatic, cryptorchid 72-year-old male patient.

scholarly journals A Giant Aggressive Angiomyxoma of the Pelvis Misdiagnosed as Incarcerated Femoral Hernia: A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Alper Sozutek ◽  
Oktay Irkorucu ◽  
Enver Reyhan ◽  
Kemal Yener ◽  
Ali Ayberk Besen ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Femoral Hernia ◽  
Surgical Excision ◽  
Reproductive Age ◽  
Positive Staining ◽  
Aggressive Angiomyxoma ◽  
Common Symptom ◽  
High Tendency ◽  
Gynecological Malignancy ◽  
Complete Surgical Excision

Aggressive angiomyxoma (AA) is an uncommon mesenchymal tumor that is mostly derived from the female pelvic and perineal regions. AA is a locally infiltrative slow growing tumor with a marked tendency to local recurrence. Painless swelling located around the genitofemoral region is the common symptom; thus, it is often misdiagnosed as a gynecological malignancy or a groin hernia. A 35-year-old female patient who previously underwent surgery for left femoral hernia operation resulting in surgical failure was reoperated for a giant AA located in the pelvis. The tumor was completely excised with free margins. Histopathologic examination revealed an AA. The tumor size was measured as 24 × 12 × 6 cm with a weight of 4.2 kg. Immunohistochemically, the cells show positive staining with vimentin, desmin, estrogen, and progesterone receptor. S100, MUC4, CD34, and SMA were negative in the tumor cells. AA should be considered in the differential diagnosis of any painless swelling located in the genitofemoral region, particularly in women of reproductive age. The principle treatment should be complete surgical excision with tumor-free margins. Long-term follow-up and careful monitoring are essential due to its high tendency of local recurrence in spite of wide excision of the tumor. Adjuvant antihormonal therapy yields promising results for preventing recurrence.

Refractory Ascites as the Only Presenting Symptom of Chronic Calcified Constrictive Pericarditis: A Diagnostic Challenge

2014 ◽  
Vol 17 (1) ◽  
pp. 42
Author(s):  
Shi-Min Yuan
Keyword(s):  
Computed Tomography ◽  
Liver Cirrhosis ◽  
Female Patient ◽  
Constrictive Pericarditis ◽  
Delayed Diagnosis ◽  
Young Female ◽  
Refractory Ascites ◽  
Diagnostic Challenge ◽  
Massive Ascites ◽  
History Of

Extracardiac manifestations of constrictive pericarditis, such as massive ascites and liver cirrhosis, often cover the true situation and lead to a delayed diagnosis. A young female patient was referred to this hospital due to a 4-year history of refractory ascites as the only presenting symptom. A diagnosis of chronic calcified constrictive pericarditis was eventually established based on echocardiography, ultrasonography, and computed tomography. Cardiac catheterization was not performed. Pericardiectomy led to relief of her ascites. Refractory ascites warrants thorough investigation for constrictive pericarditis.

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