scholarly journals Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Takuya Kishi ◽  
Yoshitaka Hirooka ◽  
Kenji Sunagawa
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Cardiovascular Events ◽  
Blood Pressure Variability ◽  
Active Phase ◽  
Early Morning ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Intracerebroventricular Infusion

Abnormal blood pressure (BP) elevation in early morning is known to cause cardiovascular events. Previous studies have suggested that one of the reasons in abnormal dairy BP variability is sympathoexcitation. We have demonstrated that brain angiotensin II type 1 receptor (AT1R) causes sympathoexcitation. The aim of the present study was to investigate whether central AT1R blockade attenuates the excess BP elevation in rest-to-active phase in hypertensive rats or not. Stroke-prone spontaneously hypertensive rats (SHRSP) were treated with intracerebroventricular infusion (ICV) of AT1R receptor blocker (ARB), oral administration of hydralazine (HYD), or ICV of vehicle (VEH). Telemetric averaged mean BP (MBP) was measured at early morning (EM), after morning (AM), and night (NT). At EM, MBP was significantly lower in ARB to a greater extent than in HYD compared to VEH, though MBP at AM was the same in ARB and HYD. At NT, MBP was also significantly lower in ARB than in HYD. These results in MBP were compatible to those in sympathoexcitation and suggest that central AT1R blockade attenuates excess BP elevation in early active phase and continuous BP elevation during rest phase independent of depressor response in hypertensive rats.

Abstract P231: Offspring of Captopril Treated Spontaneously Hypertensive Rats Have Lower Angiotensin II Type 1 Receptor Expression Which is Associated With Lower Blood Pressure

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
J X Masjoan-Juncos ◽  
Tang-Dong Liao ◽  
Ginette Bordcoch ◽  
Cesar A Romero ◽  
Oscar A Carretero
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Posterior Wall ◽  
Receptor Expression ◽  
Shr Rats ◽  
Spontaneously Hypertensive ◽  
Intracerebroventricular Infusion ◽  
Lower Blood ◽  
The Brain

It has been reported that SHR rats receiving angiotensin converting enzyme (ACE) inhibitor Captopril decrease blood pressure (BP) in at least two generation after the treatment was stopped. A decreased response to an intracerebroventricular infusion angiotensin I and angiotensin II in treated animals and their offspring was reported; however there is no reported mechanism that explains the changes observed in the untreated offspring of the Captopril treated animals. We hypothesize that captopril reduces angiotensin II type 1 receptor (AT1R) expression in CNS of the offspring of SHR rats treated with captopril. Animal groups are as follows: control animals, captopril treated animals, offspring of the control animals, offspring of the treated animals where the mother was removed from the treatment immediately after giving birth and Offspring of treated animals where the mother was removed from the treatment at weaning. BP was measured by intra-arterial method and Tail cuff. AT1R expression was measured in brain tissue using the posterior wall of the forth ventricle, as well as the top half of the brain stem. BP was different between treated groups and their offspring vs. control (Table 1). AT1R expression was significantly reduced in both offspring groups of the treated animals, when compared to control (Table 1). Therefore we conclude that captopril reduces blood pressure in the offspring of captopril treated SHR rats and that associates with a decrease in AT1R expression in CNS. Further research is necessary to determine the possible epigenetic mechanisms involved in AT1R reduction.

scholarly journals Angiotensin II Type 1 Receptor Blocker Reduces Monocyte Adhesion to Endothelial Cells in Spontaneously Hypertensive Rats

2007 ◽  
Vol 54 (4) ◽  
pp. 605-612 ◽  
Author(s):  
Fuki IKEDA ◽  
Kosuke AZUMA ◽  
Takeshi OGIHARA ◽  
Yukiko TOYOFUKU ◽  
Aiko OTSUKA ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Receptor Blocker ◽  
Monocyte Adhesion ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
Sign in / Sign up

Export Citation Format

Share Document