scholarly journals Different Effects on Inhibition of Cardiac Hypertrophy in Spontaneously Hypertensive Rats by Monotherapy and Combination Therapy of Adrenergic Receptor Antagonists and/or the Angiotensin II Type 1 Receptor Blocker under Comparable Blood Pressure Reduction

2005 ◽  
Vol 28 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Takae ASAI ◽  
Toshio KUSHIRO ◽  
Hirotaka FUJITA ◽  
Katsuo KANMATSUSE
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Combination Therapy ◽  
Adrenergic Receptor ◽  
Spontaneously Hypertensive Rats ◽  
Blood Pressure Reduction ◽  
Pressure Reduction ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Late blood pressure reduction in shr subjected to transient captopril treatment in youth: possible mechanisms

2008 ◽  
pp. 495-498
Author(s):  
J Zicha ◽  
Z Dobešová ◽  
J Kuneš
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Blood Pressure Reduction ◽  
Pressure Reduction ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Sympathetic Vasoconstriction ◽  
Captopril Treatment

Spontaneously hypertensive rats (SHR) are characterized by enhanced nifedipine-sensitive component of sympathetic vasoconstriction. Our study tried to elucidate the mechanisms responsible for long-term reduction of blood pressure (BP) in SHR subjected to early transient captopril treatment. Adult untreated SHR aged 30-34 weeks were compared with animals subjected to chronic captopril treatment for 6 weeks either in youth (between 4 and 10 weeks of age) or in adulthood (between 24 and 30 weeks of age). Antihypertensive effects of captopril were more pronounced in young than adult SHR. This was due to greater attenuation of sympathetic and nifedipine-sensitive BP components and prevention of residual BP rise in young captopril-treated SHR in which the reductions of nifedipinesensitive BP component and residual BP persisted for 20 weeks after captopril withdrawal. The magnitude of nifedipine-sensitive component of sympathetic vasoconstriction is decisive for BP maintenance not only in untreated SHR but also in SHR during active captopril treatment by or after its withdrawal.

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