scholarly journals Evaluation ofα-Glucosidase Inhibitory Effect of 50% Ethanolic Standardized Extract ofOrthosiphon stamineusBenth in Normal and Streptozotocin-Induced Diabetic Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Elsnoussi Ali Mohamed ◽  
Mariam Ahmad ◽  
Lee Fung Ang ◽  
Mohd. Zaini Asmawi ◽  
Mun Fei Yam
Keyword(s):  
Plasma Glucose ◽  
Inhibitory Activity ◽  
Ethanolic Extract ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
Lower Plasma ◽  
Antidiabetic Effect ◽  
Glucose Levels ◽  
Lower Plasma Glucose

In the present study, a 50% ethanolic extract ofOrthosiphon stamineuswas tested for itsα-glucosidase inhibitory activity.In vivoassays of the extract (containing 1.02%, 3.76%, and 3.03% of 3′hydroxy-5,6,7,4′-tetramethoxyflavone, sinensetin, and eupatorin, resp.) showed that it possessed an inhibitory activity againstα-glucosidase in normal rats loaded with starch and sucrose. The results showed that 1000 mg/kg of the 50% ethanolic extract ofO. stamineussignificantly (P<0.05) decreased the plasma glucose levels of the experimental animals in a manner resembling the effect of acarbose. In streptozotocin-induced diabetic rats, only the group treated with 1000 mg/kg of the extract showed significantly (P<0.05) lower plasma glucose levels after starch loading. Hence,α-glucosidase inhibition might be one of the mechanisms by whichO. stamineusextract exerts its antidiabetic effect. Furthermore, our findings indicated that the 50% ethanolic extract ofO. stamineuscan be considered as a potential agent for the management of diabetes mellitus.

Lowering of plasma glucose in diabetic rats by antilipolytic agents

1988 ◽  
Vol 254 (1) ◽  
pp. E23-E30 ◽  
Author(s):  
G. M. Reaven ◽  
H. Chang ◽  
H. Ho ◽  
C. Y. Jeng ◽  
B. B. Hoffman
Keyword(s):  
Glucose Uptake ◽  
Plasma Glucose ◽  
Plasma Free Fatty Acid ◽  
Diabetic Rats ◽  
Plasma Insulin Concentration ◽  
Glucose Response ◽  
Adenosine Receptor Agonist ◽  
Lower Plasma Glucose

Both nicotinic acid (NA) and the adenosine receptor agonist phenylisopropyladenosine (PIA) are potent antilipolytic agents. We have evaluated the ability of these compounds to lower plasma glucose concentration in 450-g male diabetic rats. Diabetes was induced by intravenous streptozotocin, and the rats were studied 7-10 days later. Mean (+/- SE) fasting glucose decreased 4 h after subcutaneous injections of PIA at 0 and 2 h. A similar change in plasma glucose level was also seen in rats injected with NA. The decrease in the concentration of plasma glucose in both instances was preceded by marked sustained reductions in plasma free fatty acid (FFA) concentrations; FFA decreased in PIA-injected rats and in response to NA. With injection of normal saline, neither plasma glucose nor FFA concentrations decreased in diabetic rats. There was no change in the plasma insulin concentration of rats that had hypoglycemic responses to PIA or NA. In vitro glucose uptake was determined in isolated adipocytes, and both PIA and NA were shown to increase basal and maximal insulin-stimulated glucose uptake. The stimulating effect of the two compounds was similar, and the magnitude of the effect was comparable in adipocytes from either normal or diabetic rats. As a result, neither NA nor PIA could restore the defects in glucose transport to normal in adipocytes from diabetic rats. Insulin-stimulated glucose uptake was assessed in vivo by determining the steady-state glucose response of diabetic rats to a continuous infusion of insulin and glucose and was found to be significantly enhanced in response to NA compared with NaCl.(ABSTRACT TRUNCATED AT 250 WORDS)

Mediation of β-Endorphin by Ginsenoside Rh2 to Lower Plasma Glucose in Streptozotocin-Induced Diabetic Rats

Planta Medica ◽  
2006 ◽  
Vol 72 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Dar-Ming Lai ◽  
Yong-Kwang Tu ◽  
I-Min Liu ◽  
Pei-Feng Chen ◽  
Juei-Tang Cheng
Keyword(s):  
Plasma Glucose ◽  
Diabetic Rats ◽  
Ginsenoside Rh2 ◽  
Lower Plasma ◽  
Lower Plasma Glucose

Activation of opioid μ-receptor by loperamide to lower plasma glucose in streptozotocin-induced diabetic rats

1999 ◽  
Vol 265 (3) ◽  
pp. 183-186 ◽  
Author(s):  
I.-Min Liu ◽  
Tzong-Cherng Chi ◽  
Yun Chueh Chen ◽  
Feng-Hwa Lu ◽  
Juei-Tang Cheng
Keyword(s):  
Plasma Glucose ◽  
Diabetic Rats ◽  
Lower Plasma ◽  
Lower Plasma Glucose ◽  
Μ Receptor

In vivo effect of Trigonella foenum graecum on the expression of pyruvate kinase, phosphoenolpyruvate carboxykinase, and distribution of glucose transporter (GLUT4) in alloxan-diabetic rats

2006 ◽  
Vol 84 (6) ◽  
pp. 647-654 ◽  
Author(s):  
Sameer Mohammad ◽  
Asia Taha ◽  
Kamal Akhtar ◽  
R.N.K. Bamezai ◽  
Najma Zaheer Baquer
Keyword(s):  
Skeletal Muscle ◽  
Pyruvate Kinase ◽  
Plasma Glucose ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Glucose Transporter ◽  
Diabetic Rats ◽  
Altered Expression ◽  
Glucose Levels ◽  
Glucose Transporter Glut4

Plasma glucose levels are maintained by a precise balance between glucose production and its use. Liver pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK), 2 key enzymes of glycolysis and gluconeogenesis, respectively, play a crucial role in this glucose homeostasis along with skeletal muscle glucose transporter (GLUT4). In the diabetic state, this balance is disturbed owing to the absence of insulin, the principal factor controlling this regulation. In the present study, alloxan-diabetic animals having high glucose levels of more than 300 mmol/L have been taken and the administration of Trigonella seed powder (TSP) to the diabetic animals was assessed for its effect on the expression of PK and PEPCK in liver and GLUT4 distribution in skeletal muscle of alloxan-diabetic rats. TSP treatment to the diabetic animals resulted in a marked decrease in the plasma glucose levels. Trigonella treatment partially restored the altered expression of PK and PEPCK. TSP treatment also corrected the alterations in the distribution of GLUT4 in the skeletal muscle.

Myricetin as the Active Principle ofAbelmoschus moschatusto Lower Plasma Glucose in Streptozotocin-Induced Diabetic Rats

Planta Medica ◽  
2005 ◽  
Vol 71 (7) ◽  
pp. 617-621 ◽  
Author(s):  
I-Min Liu ◽  
Shorong-Shii Liou ◽  
Ting-Wei Lan ◽  
Feng-Lin Hsu ◽  
Juei-Tang Cheng
Keyword(s):  
Plasma Glucose ◽  
Diabetic Rats ◽  
Active Principle ◽  
Lower Plasma ◽  
Lower Plasma Glucose

scholarly journals Plasma glucose levels in the association between serum trans-β-carotene and obesity among children and adolescents

2020 ◽  
Author(s):  
xiaodong zang ◽  
Hui Liu ◽  
Junqiang Zheng ◽  
Ming Fan ◽  
Xian Shen ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Inflection Point ◽  
Continuous Variable ◽  
P Value ◽  
Inverse Association ◽  
Linear Regression Models ◽  
Lower Plasma ◽  
Glucose Levels ◽  
Lower Plasma Glucose ◽  
Β Carotene

Abstract Background Results on the association between trans-β-carotene and obesity are less clear and little is known about how their relationship may be affected by plasma glucose levels.The present study aimed to evaluate the relationships between trans-β-carotene and obesity and to investigate whether plasma glucose levels had a modifying effect on these relationships. Methods Children aged 6-18 years were selected from the National Health and Nutrition Examination Survey(NHANES) (2001–2006) (n =8030). The serum trans-β-carotene levels were divided into tertiles, and their associations with obesity were evaluated using multivariable-adjusted linear regression models adjusted for potential confounding factors. The interaction effects between trans-β-carotene levels and plasma glucose levels on obesity were further evaluated. Results In the fully adjusted model, using serum trans-β-carotene as natural log-transformed continuous variable, the negative association between trans-β-carotene level and obesity were confirmed. In addition, plasma glucose levels significantly modified the inverse association between trans-β-carotene and obesity (p value for interaction: 0.09). A stronger association of trans-β-carotene levels with obesity was found in higher plasma glucose levels (more than100 mg/dl) than in lower plasma glucose levels. Further, a non-linear relationship was detected between trans-β-carotene and obesity in participants with higher plasma glucose levels, with an inflection point of 2.7 (trans-β-carotene =14.88 ug/dl). The effect sizes and confidence intervals for the left and right sides of the inflection point were 0.10 (0.00 to 0.2) and 6.7 (0.1 to 348.2), respectively. Conclusion Our findings indicate that the association between trans-β-carotene concentration and obesity is stronger in individuals with higher plasma glucose population than in those with lower plasma glucose levels.

Metformin can Activate Imidazoline I-2 Receptors to Lower Plasma Glucose in Type 1-like Diabetic Rats

2010 ◽  
Vol 43 (01) ◽  
pp. 26-30 ◽  
Author(s):  
J.-P. Lee ◽  
W. Chen ◽  
H.-T. Wu ◽  
K.-C. Lin ◽  
J.-T. Cheng
Keyword(s):  
Plasma Glucose ◽  
Diabetic Rats ◽  
Lower Plasma ◽  
Lower Plasma Glucose
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