scholarly journals InvasiveMicroascus trigonosporusSpecies Complex Pulmonary Infection in a Lung Transplant Recipient

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Kelly E. Schoeppler ◽  
Martin R. Zamora ◽  
Noelle M. Northcutt ◽  
Gerard R. Barber ◽  
Gayle O’Malley-Schroeder ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Lung Transplant ◽  
Drug Exposure ◽  
Fungal Infections ◽  
Organ Transplant ◽  
Antifungal Prophylaxis ◽  
Lung Transplant Recipient ◽  
Invasive Infection ◽  
Solid Organ ◽  
High Incidence

Because of the high incidence of morbidity and mortality associated with invasive fungal infections, antifungal prophylaxis is often used in solid organ transplant recipients. However, this prophylaxis is not universally effective and may contribute to the selection of emerging, resistant pathogens. Here we present a rare case of invasive infection caused byMicroascus trigonosporusspecies complex in a human, which developed during voriconazole prophylaxis in a lung transplant recipient. Nebulized liposomal amphotericin B was used in addition to systemic therapy in order to optimize antifungal drug exposure; this regimen appeared to reduce the patient’s fungal burden. Despite this apparent improvement, the patient’s pulmonary status progressively declined in the setting of multiple comorbidities, ultimately leading to respiratory failure and death.

scholarly journals Lung Transplant Recipient with Pulmonary Alveolar Proteinosis

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Sofya Tokman ◽  
M. Frances Hahn ◽  
Hesham Abdelrazek ◽  
Tanmay S. Panchabhai ◽  
Vipul J. Patel ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Lung Transplant ◽  
Pulmonary Alveolar Proteinosis ◽  
Mammalian Target Of Rapamycin ◽  
Organ Transplant ◽  
Lung Transplant Recipient ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Solid Organ Transplant Recipients ◽  
Alveolar Proteinosis

Pulmonary alveolar proteinosis (PAP) is a progressive lung disease characterized by accumulated surfactant-like lipoproteinaceous material in the alveoli and distal bronchioles. This accumulation is the result of impaired clearance by alveolar macrophages. PAP has been described in 11 solid organ transplant recipients, 9 of whom were treated with mammalian target of rapamycin inhibitors. We report a case of a lung transplant recipient treated with prednisone, mycophenolate mofetil (MMF), and tacrolimus who ultimately developed PAP, which worsened when MMF was replaced with everolimus.

scholarly journals Respiratory Failure due to Possible Donor-DerivedSporothrix schenckiiInfection in a Lung Transplant Recipient

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Nathan C. Bahr ◽  
Katherine Janssen ◽  
Joanne Billings ◽  
Gabriel Loor ◽  
Jaime S. Green
Keyword(s):  
Transplant Recipient ◽  
Lung Transplant ◽  
Fungal Infections ◽  
Early Recognition ◽  
Organ Procurement ◽  
Sporothrix Schenckii ◽  
The United States ◽  
Lung Transplant Recipient ◽  
Solid Organ ◽  
First Case

Background. De novo and donor-derived invasive fungal infections (IFIs) contribute to morbidity and mortality in solid organ transplant (SOT) recipients. Reporting of donor-derived IFIs (DDIFIs) to the Organ Procurement Transplant Network has been mandated since 2005. Prior to that time no systematic monitoring of DDIFIs occurred in the United States.Case Presentation. We report a case of primary graft dysfunction in a 49-year-old male lung transplant recipient with diffuse patchy bilateral infiltrates likely related to pulmonarySporothrix schenckiiinfection. The organism was isolated from a bronchoalveolar lavage on the second day after transplantation. Clinical and radiographic responses occurred after initiation of amphotericin B lipid formulation.Conclusion. We believe that this was likely a donor-derived infection given the early timing of theSporothrixisolation after transplant in a bilateral single lung transplant recipient. This is the first case report of sporotrichosis in a lung transplant recipient. Our patient responded well to amphotericin induction therapy followed by maintenance therapy with itraconazole. The implications of donor-derived fungal infections andSporothrixin transplant recipients are reviewed. Early recognition and management of these fungi are essential in improving outcomes.

scholarly journals Ceftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation in a lung transplant recipient

2018 ◽  
Author(s):  
Fabio Arena ◽  
Luca Marchetti ◽  
Lucia Henrici De Angelis ◽  
Enivarco Maglioni ◽  
Martina Contorni ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Transplant Recipient ◽  
Extracorporeal Membrane Oxygenation ◽  
Lung Transplant ◽  
Drug Exposure ◽  
Pulmonary Infection ◽  
Lung Transplant Recipient ◽  
Membrane Oxygenation ◽  
Optimal Drug

AbstractCeftolozane-tazobactam pharmacokinetics during extracorporeal membrane oxygenation (ECMO) has not been previously studied. In this work we report on the ceftolozane and tazobactam plasmatic levels in a lung transplant recipient during ECMO, treated with ceftolozane-tazobactam (2g/1g, intravenously every 8 h, 1 h infusion) for a Pseudomonas aeruginosa pulmonary infection. Ceftolozane Cmax and Cmin, monitored during 96 hrs, remained above 60 and 20 μg/mL, respectively, with optimal drug exposure (100% %TMIC). Tazobactam levels were above 1.9 μg/mL.

scholarly journals BDUMP: A Rare Case of Vision Loss in a Lung Transplant Recipient

2021 ◽  
Vol 40 (4) ◽  
pp. S509-S510
Author(s):  
M. Barraza ◽  
J. Rosenheck ◽  
B.C. Keller ◽  
I. Livshitz ◽  
M.M. Howsare
Keyword(s):  
Transplant Recipient ◽  
Rare Case ◽  
Lung Transplant ◽  
Vision Loss ◽  
Lung Transplant Recipient

Splenic abscess caused by Toxocara spp. in a lung transplant recipient, Marseille, France

2021 ◽  
Author(s):  
Quentin Balacheff ◽  
Jean‐Baptiste Lovato ◽  
Benjamin Coiffard ◽  
Coralie L’Ollivier ◽  
Nadim Cassir ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Lung Transplant ◽  
Splenic Abscess ◽  
Lung Transplant Recipient

scholarly journals Hemophagocytic Lymphohistiocytosis in a Lung Transplant Recipient

2021 ◽  
Vol 40 (4) ◽  
pp. S510
Author(s):  
D. Rudym ◽  
M. Lesko ◽  
S. Chang ◽  
Z. Kon ◽  
K. Sureau ◽  
...  
Keyword(s):  
Transplant Recipient ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Lung Transplant ◽  
Lung Transplant Recipient
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