scholarly journals Systematic Review of Randomized Clinical Trials on Safety and Efficacy of Pharmacological and Nonpharmacological Treatments for Retinitis Pigmentosa

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Marta Sacchetti ◽  
Flavio Mantelli ◽  
Daniela Merlo ◽  
Alessandro Lambiase
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Retinitis Pigmentosa ◽  
Randomized Clinical Trials ◽  
Clinical Results ◽  
Medical Treatments ◽  
Safety And Efficacy ◽  
Medical Interventions ◽  
Nonpharmacological Treatments

Aims.Several treatments have been proposed to slow down progression of Retinitis pigmentosa (RP), a hereditary retinal degenerative condition leading to severe visual impairment. The aim of this study is to systematically review data from randomized clinical trials (RCTs) evaluating safety and efficacy of medical interventions for the treatment of RP.Methods.Randomized clinical trials on medical treatments for syndromic and nonsyndromic RP published up to December 2014 were included in the review. Visual acuity, visual field, electroretinogram, and adverse events were used as outcome measures.Results.The 19 RCTs included in this systematic review included trials on hyperbaric oxygen delivery, topical brimonidine tartrate, vitamins, docosahexaenoic acid, gangliosides, lutein, oral nilvadipine, ciliary neurotrophic factor, and valproic acid. All treatments proved safe but did not show significant benefit on visual function. Long term supplementation with vitamin A showed a significantly slower decline rate in electroretinogram amplitude.Conclusions.Although all medical treatments for RP appear safe, evidence emerging from RCTs is limited since they do not present comparable results suitable for quantitative statistical analysis. The limited number of RCTs, the poor clinical results, and the heterogeneity among studies negatively influence the strength of recommendations for the long term management of RP patients.

Dupilumab safety and efficacy in uncontrolled asthma: a systematic review and meta-analysis of randomized clinical trials

2018 ◽  
Vol 56 (10) ◽  
pp. 1110-1119 ◽  
Author(s):  
Yazan Zayed ◽  
Babikir Kheiri ◽  
Momen Banifadel ◽  
Michael Hicks ◽  
Ahmed Aburahma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Uncontrolled Asthma ◽  
Safety And Efficacy

scholarly journals Effect of Orthodontic Treatment on Tooth Autotransplantation: Systematic Review of Controlled Clinical Trials

2020 ◽  
Vol 14 (03) ◽  
pp. 467-482
Author(s):  
Rogério Lacerda-Santos ◽  
Rhaíssa Ferreira Canutto ◽  
José Lucas dos Santos Araújo ◽  
Fabiola Galbiatti de Carvalho ◽  
Eliseu Aldrighi Münchow ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Risk Of Bias ◽  
Significant Heterogeneity ◽  
Controlled Clinical Trials ◽  
Periodontal Tissues ◽  
Orthodontic Movement ◽  
Anterior Teeth

AbstractThis systematic review was focused on evaluating tooth autotransplantation, considering its impacts on the teeth, bone, soft tissues, and aesthetics in orthodontic patients. A bibliographic search was conducted without limitations on year of publication or language in the databases of PubMed, Web of Science, Scopus, Medline Complete, Cochrane, Clinical Trials, and Trials Central. For triage of articles, indications, surgical planning, orthodontic movement, risk factors for treatment, and long-term follow-ups were considered. For outcomes, the results with reference to teeth, alveolar bone, periodontal tissues, and esthetic satisfaction were considered. Risk of bias was evaluated using the methodological index for nonrandomized studies-MINORS. The results showed 10 controlled clinical trials, and no randomized clinical trials were found. The selected studies included 715 patients and 934 autotransplanted teeth among which there were premolars, molars, and anterior teeth evaluated in the long term, indicating that orthodontics associated with autotransplantation indicated a result that was generally clinically acceptable. The quality of the set of evidence was considered medium due to the presence of different methodological problems, risk of bias, and significant heterogeneity in the evaluated studies. There was a sufficient body of evidence that justified autotransplantation in patients who needed orthodontic movement. In teeth, there was an increase in root resorption influenced by orthodontics, but without impacting on the general clinical result in the long term. Bone and periodontal tissue do not appear to be affected by orthodontics. The patient’s aesthetic satisfaction was not considered in the studies.

scholarly journals Long-term aspirin use for primary cancer prevention: An updated systematic review and subgroup meta-analysis of 29 randomized clinical trials

2020 ◽  
Vol 11 (21) ◽  
pp. 6460-6473
Author(s):  
Qibiao Wu ◽  
Xiaojun Yao ◽  
Hongwei Chen ◽  
Zhengtang Liu ◽  
Ting Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Cancer Prevention ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Primary Cancer

scholarly journals The Effects of Nonpharmacological Treatment on Uremic Pruritus Patients: A Systematic Review

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Chiu-Feng Wu ◽  
Ya-Chu Hsiao ◽  
Pi-Chen Ko
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Cost Effective ◽  
Hemodialysis Patients ◽  
Inclusion Criteria ◽  
Uremic Pruritus ◽  
Jadad Scale ◽  
Analysis And Synthesis ◽  
Nonpharmacological Treatments

Background. Around 50–90% of hemodialysis patients develop pruritus. Although studies examining nonpharmacological treatments for itchy skin have been conducted, the conclusions have not been decisive. Purpose. Through a systematic review of the literature, this study aimed to understand nonpharmacological interventions carried out in clinical trials for uremic pruritus and to evaluate and consolidate the information regarding these improvements and their effectiveness. Methods. A literature search focusing on studies published between January 2004 and December 2013 was conducted from 5 electronic databases. After screening based on inclusion criteria and excluding duplicates, nonpharmacological treatments examined in randomized clinical trials were selected for further analysis and synthesis. A modified Jadad scale was used to evaluate the quality of the identified articles. Results. Seven nonpharmacological studies met the inclusion criteria. The interventions to improve uremic pruritus included using emollients, phototherapy, acupuncture, and thermal therapy. Research showed that using emollients, phototherapy, and acupuncture significantly reduces uremic pruritus. Conclusion. Nonpharmacological interventions are effective for hemodialysis patients with pruritus. Emollients were found to provide the most relief compared to the other methods and constitute a readily available and cost-effective intervention to improve pruritus symptoms.

scholarly journals ¿Disponemos de un protocolo "ideal" en la intubación con fibrobroncoscopio en el paciente con vía aérea difícil anticipada? Revisión

2020 ◽  
Vol 12 (5) ◽  
pp. 2
Author(s):  
Natalia Muñoz Ávalos ◽  
Jara Palamidessi Domínguez
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Usual Care ◽  
Randomized Clinical Trials ◽  
Surgical Intervention ◽  
Care Practice ◽  
Awake Patient ◽  
Safety And Efficacy ◽  
Revisión Sistemática ◽  
Great Heterogeneity

La intubación con fibrobroncoscopio en el paciente despierto supone una buena opción para aquellos pacientes con vía aérea difícil conocida que se van a someter a una intervención quirúrgica programada, lo cual permite al anestesiólogo responsable idear un plan de acción para evitar un desenlace no deseado. Son muchos los protocolos que se aplican para ello, pero, la mayoría de las veces, obedecen a la experiencia de cada anestesiólogo y a los resultados obtenidos con su aplicación en la práctica asistencial habitual.  Este artículo es la primera revisión sistemática de ensayos clínicos aleatorizados que se centran en este abordaje. Para ello, se seleccionó principalmente información de cuatro áreas de trabajo: premedicación, sedación, anestesia local y uso de dispositivos y técnicas auxiliares que faciliten la intubación en el paciente despierto. La conclusión final a la que llegan los autores de este artículo es la existencia de gran heterogeneidad en lo que a estos aspectos se refiere, sin que ninguno de los protocolos haya demostrado superioridad en seguridad y eficacia.  ABSTRACT  Do we have an "ideal" protocol in the intubation with fibrobronchoscope in the patient with difficult anticipated airway?: A review. Intubation with fibrobronchoscope in the awake patient is a good option form patient with a known difficult airway who are going to undergo a scheduled surgical intervention, which allows the responsable anesthesiologist to devise a plan of action to prevent an unwanted outcome. There are many protocols that are applied for this but most of the time are due to the experience of each anesthesiologist and the results obtained with application in the usual care practice. This article is the first systematic review or randomized clinical trials focusing on this approach. Information was mainly selected from four areas of work: premedication, sedation, local anesthesia and the use of devices and auxiliary techniques to facilitate intubation in the awake patient. The authors find a great heterogeneity as far as these aspects are concerned, without any of the protocols having demonstrated superiority in safety and efficacy.

The long-term effects of bibliotherapy in depression treatment: Systematic review of randomized clinical trials

2017 ◽  
Vol 58 ◽  
pp. 49-58 ◽  
Author(s):  
M.R. Gualano ◽  
F. Bert ◽  
M. Martorana ◽  
G. Voglino ◽  
V. Andriolo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Depression Treatment ◽  
Long Term Effects
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