The long-term effects of bibliotherapy in depression treatment: Systematic review of randomized clinical trials

2017 ◽  
Vol 58 ◽  
pp. 49-58 ◽  
Author(s):  
M.R. Gualano ◽  
F. Bert ◽  
M. Martorana ◽  
G. Voglino ◽  
V. Andriolo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Depression Treatment ◽  
Long Term Effects

scholarly journals Effect of Orthodontic Treatment on Tooth Autotransplantation: Systematic Review of Controlled Clinical Trials

2020 ◽  
Vol 14 (03) ◽  
pp. 467-482
Author(s):  
Rogério Lacerda-Santos ◽  
Rhaíssa Ferreira Canutto ◽  
José Lucas dos Santos Araújo ◽  
Fabiola Galbiatti de Carvalho ◽  
Eliseu Aldrighi Münchow ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Risk Of Bias ◽  
Significant Heterogeneity ◽  
Controlled Clinical Trials ◽  
Periodontal Tissues ◽  
Orthodontic Movement ◽  
Anterior Teeth

AbstractThis systematic review was focused on evaluating tooth autotransplantation, considering its impacts on the teeth, bone, soft tissues, and aesthetics in orthodontic patients. A bibliographic search was conducted without limitations on year of publication or language in the databases of PubMed, Web of Science, Scopus, Medline Complete, Cochrane, Clinical Trials, and Trials Central. For triage of articles, indications, surgical planning, orthodontic movement, risk factors for treatment, and long-term follow-ups were considered. For outcomes, the results with reference to teeth, alveolar bone, periodontal tissues, and esthetic satisfaction were considered. Risk of bias was evaluated using the methodological index for nonrandomized studies-MINORS. The results showed 10 controlled clinical trials, and no randomized clinical trials were found. The selected studies included 715 patients and 934 autotransplanted teeth among which there were premolars, molars, and anterior teeth evaluated in the long term, indicating that orthodontics associated with autotransplantation indicated a result that was generally clinically acceptable. The quality of the set of evidence was considered medium due to the presence of different methodological problems, risk of bias, and significant heterogeneity in the evaluated studies. There was a sufficient body of evidence that justified autotransplantation in patients who needed orthodontic movement. In teeth, there was an increase in root resorption influenced by orthodontics, but without impacting on the general clinical result in the long term. Bone and periodontal tissue do not appear to be affected by orthodontics. The patient’s aesthetic satisfaction was not considered in the studies.

scholarly journals Long-term aspirin use for primary cancer prevention: An updated systematic review and subgroup meta-analysis of 29 randomized clinical trials

2020 ◽  
Vol 11 (21) ◽  
pp. 6460-6473
Author(s):  
Qibiao Wu ◽  
Xiaojun Yao ◽  
Hongwei Chen ◽  
Zhengtang Liu ◽  
Ting Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Cancer Prevention ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Primary Cancer

scholarly journals Systematic Review of Randomized Clinical Trials on Safety and Efficacy of Pharmacological and Nonpharmacological Treatments for Retinitis Pigmentosa

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Marta Sacchetti ◽  
Flavio Mantelli ◽  
Daniela Merlo ◽  
Alessandro Lambiase
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Retinitis Pigmentosa ◽  
Randomized Clinical Trials ◽  
Clinical Results ◽  
Medical Treatments ◽  
Safety And Efficacy ◽  
Medical Interventions ◽  
Nonpharmacological Treatments

Aims.Several treatments have been proposed to slow down progression of Retinitis pigmentosa (RP), a hereditary retinal degenerative condition leading to severe visual impairment. The aim of this study is to systematically review data from randomized clinical trials (RCTs) evaluating safety and efficacy of medical interventions for the treatment of RP.Methods.Randomized clinical trials on medical treatments for syndromic and nonsyndromic RP published up to December 2014 were included in the review. Visual acuity, visual field, electroretinogram, and adverse events were used as outcome measures.Results.The 19 RCTs included in this systematic review included trials on hyperbaric oxygen delivery, topical brimonidine tartrate, vitamins, docosahexaenoic acid, gangliosides, lutein, oral nilvadipine, ciliary neurotrophic factor, and valproic acid. All treatments proved safe but did not show significant benefit on visual function. Long term supplementation with vitamin A showed a significantly slower decline rate in electroretinogram amplitude.Conclusions.Although all medical treatments for RP appear safe, evidence emerging from RCTs is limited since they do not present comparable results suitable for quantitative statistical analysis. The limited number of RCTs, the poor clinical results, and the heterogeneity among studies negatively influence the strength of recommendations for the long term management of RP patients.

scholarly journals The Shortcomings of Clinical Practice Guidelines

Cardiology ◽  
2015 ◽  
Vol 130 (3) ◽  
pp. 187-200 ◽  
Author(s):  
Konstantinos Dean Boudoulas ◽  
Carl V. Leier ◽  
Paraschos Geleris ◽  
Harisios Boudoulas
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Randomized Clinical Trials ◽  
Medical Knowledge ◽  
Long Term Effects ◽  
New Research ◽  
Lost In Translation

Accumulation of medical knowledge related to diagnosis and management over the last 5-6 decades has altered the course of diseases, improved clinical outcomes and increased survival. Thus, it has become difficult for the practicing physician to evaluate the long-term effects of a particular therapy on survival of an individual patient. Further, the approach by each physician to an individual patient with the same disease is not always uniform. In an attempt to assist physicians in applying newly acquired knowledge to patients, clinical practice guidelines were introduced by various scientific societies. Guidelines assist in facilitating the translation of new research discoveries into clinical practice; however, despite the improvements over the years, there are still several issues related to guidelines that often appear ‘lost in translation'. Guidelines are based on the results of randomized clinical trials, other nonrandomized studies, and expert opinion (i.e. the opinion of most members of the guideline committees). The merits and limitations of randomized clinical trials, guideline committees, and presentation of guidelines will be discussed. In addition, proposals to improve guidelines will be presented.

scholarly journals Long-term randomized clinical trials of pharmacological treatment of obesity: Systematic review

1969 ◽  
Vol 41 (1) ◽  
pp. 17-25
Author(s):  
Lidia Castañeda-González ◽  
Rafael Camberos-Solís ◽  
Monserrat Bacardí-Gascón ◽  
Arturo Jiménez-Cruz
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Pharmacological Treatment ◽  
Randomized Clinical Trials ◽  
Treatment Of Obesity

scholarly journals Catheter Ablation vs. Anti-Arrhythmic Drugs as First-Line Treatment in Symptomatic Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

2021 ◽  
Vol 8 ◽  
Author(s):  
Andrea Saglietto ◽  
Fiorenzo Gaita ◽  
Roberto De Ponti ◽  
Gaetano Maria De Ferrari ◽  
Matteo Anselmino
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Clinical Trials ◽  
Catheter Ablation ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Rhythm Control ◽  
First Line ◽  
Atrial Tachyarrhythmias

Background: Catheter ablation has become a well-established indication for long-term rhythm control in atrial fibrillation (AF) patients refractory to anti-arrhythmic drugs (AADs). Efficacy and safety of AF catheter ablation (AFCA) before AADs failure are, instead, questioned.Objective: The aim of the study was to perform a systematic review and meta-analysis of randomized clinical trials (RCTs) comparing first-line AFCA with AADs in symptomatic patients with paroxysmal AF.Methods: We performed a random-effects meta-analysis of binary outcome events comparing AFCA with AADs in rhythm control-naïve patients. The primary outcomes, also stratified by the type of ablation energy (radiofrequency or cryoenergy), were (1) recurrence of atrial tachyarrhythmias and (2) recurrence of symptomatic atrial tachyarrhythmias. The secondary outcomes included adverse events.Results: Six RCTs were included in the analysis. AFCA was associated with lower recurrences of atrial tachyarrhythmias [relative risk (RR) 0.58, 95% confidence interval (CI) 0.46–0.72], consistent across the two types of ablation energy (radiofrequency, RR 0.50, 95% CI 0.28–0.89; cryoenergy, RR 0.60, 95% CI 0.50–0.72; p-value for subgroup differences: 0.55). Similarly, AFCA was related to less symptomatic arrhythmic recurrences (RR 0.46, 95% CI 0.27–0.79). Overall, adverse events did not differ. A trend toward increased periprocedural cardiac tamponade or phrenic nerve palsy was observed in the AFCA group, while more atrial flutter episodes with 1:1 atrioventricular conduction and syncopal events were reported in the AAD group.Conclusions: First-line rhythm control therapy with AFCA, independent from the adopted energy source (radiofrequency or cryoenergy), reduces long-term arrhythmic recurrences in patients with symptomatic paroxysmal AF compared with AADs.

scholarly journals Efficacy of Nebulised Tobramycin in Cystic Fibrosis Management: A Systematic Review

2019 ◽  
pp. 1-10
Author(s):  
G. T. Olowe
Keyword(s):  
Systematic Review ◽  
Cystic Fibrosis ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Genetic Diseases ◽  
Routes Of Administration ◽  
Pulmonary Functions ◽  
Different Populations ◽  
Review Study

Cystic Fibrosis (CF) is a progressive clinical condition associated with decreased functionality of glands that produce mucus, sweat, and intestinal secretions. CF is one of the most common recessive genetic diseases that affect all ethnic groups without any known identified cure, having variations in the severity of symptoms. In the treatment and management of CF, The choice and routes of administration of antibiotics taken is important in assessing effectiveness at different populations. In the light of this, current study was undertaken to determine the efficacy of Nebulised Tobramycin (NT) in the treatment of mild to moderate CF within 8years study period. Study was achieved by searching known repositories and electronic databases of various sources. Randomized Clinical Trials (RCTs) that compares patients treated on NT and placebo were selected, including six (6) RCTs comprising 609 participants to the review. Study noticed significant clinical and methodological heterogeneity among trials with NT, varying over a total of 8years study period. Also, there were recorded evidences of improvement in pulmonary function in most of the patients, following completion of the study. This review revealed inconclusive evidence in the efficacy of NT in the treatment of mild to moderate CF. It is thus clear, that long term use of NT in mild to moderate CF can provide sustained improvements in pulmonary functions.

Sign in / Sign up

Export Citation Format

Share Document