scholarly journals Ovarian Seromucinous Borderline Tumor and Clear Cell Carcinoma: An Unusual Combination

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Eriko Nakamura ◽  
Yuichiro Sato ◽  
Sayaka Moriguchi ◽  
Atsushi Yamashita ◽  
Takashi Higo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Tumor Cells ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
English Literature ◽  
Borderline Tumor ◽  
Borderline Tumors ◽  
First Case ◽  
Napsin A ◽  
Unusual Combination

Ovarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous borderline tumors but are much more frequently associated with endometriosis. The coexistence of other tumors with seromucinous tumors is also extremely rare. Here, we report an unusual combination of bilateral ovarian SMBT and clear cell carcinoma associated with polypoid endometriosis of the colon, in a 62-year-old woman. There was no transitional lesion between the two tumors. Immunohistochemistry showed different staining patterns in tumor components. Seromucinous tumor cells were positive for estrogen receptor (ER) and progesterone receptor (PgR) but negative for Napsin A, p504S, and HNF1B. Clear cell tumor cells were positive for Napsin A and p504S and focally positive for HNF1B but negative for ER and PgR. Loss of ARID1A expression was not observed in SMBTs, clear cell tumors, or endometriosis. These findings suggest that these tumors arose from separate endometriosis foci and collided within the same ovary. To the best of our knowledge, this is the first case of this unusual combination of ovarian seromucinous tumor and clear cell carcinoma to be reported in the English literature.

scholarly journals PD-L1/PD-1 Expression in Endometrial Clear Cell Carcinoma: A Potential Surrogate Marker for Clinical Trials

2019 ◽  
Vol 28 (1) ◽  
pp. 31-37
Author(s):  
Cao Jin ◽  
Sean Hacking ◽  
Sharon Liang ◽  
Mansoor Nasim
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Surrogate Marker ◽  
Myometrial Invasion ◽  
Lymphocyte Infiltration ◽  
Pathological Features ◽  
Napsin A ◽  
Programmed Death ◽  
Clinical And Pathological Features

Background. Endometrial clear cell carcinoma (ECCC) represents a rare subtype of endometrial cancer. Recently, immunotherapeutic drugs targeting programmed cell death protein 1 (PD-1)/programmed death ligand-1 (PD-L1) was associated with improved survival in several types of cancer (especially in patients with mismatch-repair (MMR)-deficient status). The aim of this study is to evaluate the correlation between the PD-L1/PD-1 axis and clinical and pathological features in strictly defined ECCC diagnosed at our institution. Design. Review of ECCC (diagnosed in the period of 2000 to 2017) identified 23 cases (n = 23) in our institution. The cases were reviewed by 2 gynecological pathologists. Estrogen receptor, progesterone receptor, napsin A, p16, and p53 were also performed so that only pure CCC cases were included. PD-L1 (SP142), PD-1, and MMR antibodies were performed. PD-L1 and PD-1 were scored in both the tumor and the peritumoral lymphocyte infiltration. Clinical and pathological features were recorded to correlate with the expression of the 2 markers. Results. Among the 23 cases, 20 cases were qualified for pure CCC by histology and immunohistochemistry patterns. Regarding PD-1 expression, 6/20 (30%) patients had positive expression in peritumoral lymphocyte infiltration. While 3/20 (15%) cases had PD-L1 either tumoral or peritumoral lymphocytes expression. Loss of MMR expression was present in 1 (5%) of 20 patients. PD-1 and/or PD-L1 expression cases tended to have deeper myometrial invasion and higher stage at presentation. Conclusions. Our results are suggestive of the roles of both PD-1 and PD-L1 in ECCCs as useful therapeutic biomarkers for immunotherapy.

scholarly journals Primitive neuroectodermal tumour with synchronous ipsilateral clear cell carcinoma of the kidney

2018 ◽  
Vol 11 (1) ◽  
pp. e224273
Author(s):  
Mohamed Taha ◽  
Nur M Mohammed ◽  
Stephen Crowther ◽  
Rustom P Manecksha ◽  
Arun Z Thomas
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Left Kidney ◽  
Disease Recurrence ◽  
Cell Renal Cell Carcinoma ◽  
Primitive Neuroectodermal Tumour ◽  
Neuroectodermal Tumour ◽  
First Case ◽  
Solid Lesions

We report the first case of a synchronous ipsilateral primitive neuroectodermal tumour (PNET) and clear cell renal cell carcinoma of the kidney. A 37-year-old man presented to the emergency department with a 24-hour history of colicky abdominal pain and visible haematuria. He had no relevant surgical or medical history. Physical examination was unremarkable apart from mild left flank tenderness. Triphasic CT of the abdomen and pelvis showed two solid lesions in the left kidney. Further staging CT of the chest showed no evidence of local or distal metastasis. He subsequently underwent laparoscopic radical nephrectomy. Pathological analysis of the kidney showed two synchronous renal tumours, a clear cell carcinoma and PNET of the kidney. The patient received adjuvant chemotherapy according to Ewing’s sarcoma chemotherapy protocol. Surveillance CT scans at 3, 6 and 12 months showed no evidence of disease recurrence or metastasis.

Clear cell carcinoma arising in pleomorphic adenoma of the minor salivary gland

1989 ◽  
Vol 103 (8) ◽  
pp. 789-791 ◽  
Author(s):  
Jerzy Klijanienko ◽  
Christian Micheau ◽  
Guy Schwaab ◽  
Patrick Marandas ◽  
Sam Friedman
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
English Literature ◽  
Relevant Literature ◽  
Minor Salivary Gland ◽  
A Minor

AbstractMalignant change arising in pleomorphic adenoma of the salivary glands is uncommon, with a reported incidence of 2–10 per cent.Only one case where a pleomorphic adenoma became a clear cell carcinoma appears to have been published in the English literature. An additional case of clear cell carcinoma arising in pleomorphic adenoma of a minor salivary gland is reported and the relevant literature discussed.

scholarly journals A Case of Hyalinizing Clear Cell Carcinoma, So-Called Clear Cell Carcinoma, Not Otherwise Specified, of the Minor Salivary Glands of the Buccal Mucosa

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Takahiro Yamanishi ◽  
Kiwako Kutsuma ◽  
Keisuke Masuyama
Keyword(s):  
Cell Carcinoma ◽  
Salivary Glands ◽  
Tumor Cells ◽  
Buccal Mucosa ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Minor Salivary Glands ◽  
Hyalinizing Clear Cell Carcinoma ◽  
Not Otherwise Specified ◽  
The Right

Hyalinizing clear cell carcinoma (HCCC), so-called clear cell carcinoma, not otherwise specified (CCC (NOS)), of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS) (referred to as HCCC) of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.

Frequent Expression of Napsin A in Clear Cell Carcinoma of the Endometrium

2014 ◽  
Vol 38 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Oluwole Fadare ◽  
Mohamed M. Desouki ◽  
Katja Gwin ◽  
Krisztina Z. Hanley ◽  
Elke A. Jarboe ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Napsin A
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