scholarly journals Risk Factors for Premenopausal Breast Cancer in Bangladesh

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Javaid Iqbal ◽  
Tahmina Ferdousy ◽  
Rahela Dipi ◽  
Reza Salim ◽  
Wei Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Premenopausal Women ◽  
Breast Cancer Diagnosis ◽  
Age At Menarche ◽  
Premenopausal Breast Cancer ◽  
Factors Associated ◽  
History Of

Background. The incidence of premenopausal breast cancer is rising throughout South Asia. Our objective was to determine the role of risk factors associated with Westernization for premenopausal breast cancer in Bangladesh.Methods. We conducted a matched case-control study between January 1, 2007, and December 31, 2010, at four hospitals in Bangladesh. Cases were premenopausal women diagnosed with invasive breast cancer. Controls were premenopausal women with no personal history of breast cancer. Logistic regression was used to calculate the odds ratios (OR) for breast cancer.Results. We identified 129 age-matched pairs. The mean age of breast cancer diagnosis was 37.5 years. Each year decrease in the age of menarche significantly increased the risk of breast cancer (OR = 1.67, 95% CI 1.09–2.56,P=0.02). The risk was also increased with a current body mass index of ≥25 kg/m2(OR = 5.24, 95% CI 1.10–24.9,P=0.04). Age at first childbirth, parity, and breastfeeding were not significantly associated with premenopausal breast cancer risk (P>0.05).Conclusions. Age at menarche and adult weight gain were associated with premenopausal breast cancer risk. Other factors associated with Westernization may not be relevant to premenopausal breast cancer risk in Bangladesh.

scholarly journals Assessment of Breast Cancer Risk Based on Mammary Gland Volume Measured with CT

2010 ◽  
Vol 4 ◽  
pp. BCBCR.S5248 ◽  
Author(s):  
Megumi Kuchiki ◽  
Takaaki Hosoya ◽  
Akira Fukao
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Odds Ratio ◽  
Premenopausal Women ◽  
Breast Cancer Patients ◽  
History Of ◽  
The Relationship

We investigated the relationship between mammary gland volume (MGV) of the breast as measured with three-dimensional chest computed tomography (CT) and breast cancer risk. Univariate analysis was used to assess the relationship between MGV and known risk factors in 427 healthy women. A case control study (97 cases and 194 controls) was conducted to assess breast cancer risk. MGV was significantly smaller for postmenopausal women than for premenopausal women, and was significantly larger for women with a family history of breast cancer than for women without. MGV, body mass index (BMI), and rate of family history of breast cancer were significantly higher among breast cancer patients than among healthy women, and number of deliveries was significantly lower among breast cancer patients. In postmenopausal women, age at menarche was significantly younger for breast cancer patients. MGV correlated well with breast cancer risk factors. The highest odds ratio was 4.9 for premenopausal women with the largest MGV. Regardless of menopausal status, the greater the MGV, the higher the odds ratio. Our results constitute the first reliable data on the relationship between MGV and breast cancer obtained through exact volume analysis.

scholarly journals DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Minyuan Chen ◽  
Ee Ming Wong ◽  
Tuong L. Nguyen ◽  
Gillian S. Dite ◽  
Jennifer Stone ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Biological Age ◽  
Age At Menarche ◽  
Cancer Risk Factors ◽  
Genome Wide ◽  
Breast Cancer Risk Factors

Abstract DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict breast cancer risk. We aimed to investigate the associations between these DNA methylation-based risk factors and 18 conventional breast cancer risk factors for disease-free women. A sample of 479 individuals from the Australian Mammographic Density Twins and Sisters was used for discovery, a sample of 3354 individuals from the Melbourne Collaborative Cohort Study was used for replication, and meta-analyses pooling results from the two studies were conducted. DNAm age based on three epigenetic clocks (Hannum, Horvath and Levine) and genome-wide average DNA methylation were calculated using the HumanMethylation 450 K BeadChip assay data. The DNAm age measures were positively associated with body mass index (BMI), smoking, alcohol drinking and age at menarche (all nominal P < 0.05). Genome-wide average DNA methylation was negatively associated with smoking and number of live births, and positively associated with age at first live birth (all nominal P < 0.05). The association of DNAm age with BMI was also evident in within-twin-pair analyses that control for familial factors. This study suggests that some lifestyle and hormonal risk factors are associated with these DNA methylation-based breast cancer risk factors, and the observed associations are unlikely to be due to familial confounding but are likely causal. DNA methylation-based risk factors could interplay with conventional risk factors in modifying breast cancer risk.

Breast Cancer Risk Factors in Two Distinct Ethnic Groups: Indian and Pakistani vs. American Premenopausal Women

1999 ◽  
Vol 35 (1) ◽  
pp. 16-26 ◽  
Author(s):  
Savitri K. Kamath ◽  
Genoveva Murillo ◽  
Robert T. Chatterton ◽  
Erum A. Hussain ◽  
Daxa Amin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Ethnic Groups ◽  
Premenopausal Women ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors

scholarly journals Lipoprotein and metabolite associations to breast cancer risk in the HUNT2 study

2021 ◽  
Author(s):  
Julia Debik ◽  
Hartmut Schaefer ◽  
Trygve Andreassen ◽  
Feng Wang ◽  
Fang Fang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Premenopausal Women ◽  
Health Study ◽  
Breast Cancer Patients ◽  
Serum Samples ◽  
Lipoprotein Subfractions ◽  
Premenopausal Breast Cancer

Background: The aim of this study was to investigate if serum lipoprotein and metabolic profiles of healthy women can predict the risk of developing breast cancer in the future, and to gain a better understanding of the etiology of the disease. Methods: From a cohort of 70 000 participants within the Trondelag Health Study (HUNT study), we identified 1199 women who developed breast cancer within a 22 year follow-up period. Through a nested case-control study design, future breast cancer patients and matching controls (n = 2398) were analysed. Using nuclear magnetic resonance (NMR) spectroscopy, 28 metabolites and 112 lipoprotein subfractions were quantified from prediagnostic serum samples. Logistic regression was used to test metabolites and lipoprotein subfractions for associations with breast cancer risk and partial least-squares discriminant analysis (PLS-DA) models were built to predict future disease. Results: Among premenopausal women (554 cases) 14 lipoprotein subfractions were associated with long-term breast cancer risk. In specific, different subfractions of VLDL particles (in particular VLDL-2, VLDL-3 and VLDL-4) were inversely associated with breast cancer. For total VLDL: apolipoprotein B, cholesterol, free cholesterol and phospholipids were inversely associated with premenopausal breast cancer risk, and in addition total and HDL-4 triglycerides. No significant association was found in postmenopausal women. Conclusions: We identified several associations between lipoprotein subfractions and long-term risk of breast cancer in premenopausal women. Inverse associations between several VLDL subfractions and breast cancer risk were found, revealing an altered metabolism in the endogenous lipid pathway many years prior to a breast cancer diagnosis.

scholarly journals Risk of breast cancer before and after rheumatoid arthritis, and the impact of hormonal factors

2020 ◽  
Vol 79 (5) ◽  
pp. 581-586 ◽  
Author(s):  
Hjalmar Wadström ◽  
Andreas Pettersson ◽  
Karin E Smedby ◽  
Johan Askling
Keyword(s):  
Breast Cancer ◽  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Relative Risk ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors ◽  
History Of ◽  
Incident Breast Cancer

ObjectivesTo examine the risk of incident breast cancer in women with rheumatoid arthritis (RA), and the risk of RA in women with a history of breast cancer, taking antihormonal treatment for breast cancer into account.MethodsUsing nationwide Swedish registers, women with new-onset RA diagnosed in 2006–2016 were identified and analysed using a cohort and a case–control design. Each patient with RA was matched on age, sex and place of residence to five randomly selected subjects from the general population. Through register linkages, we collected information on breast cancer, breast cancer risk factors (reproductive history and hormone replacement therapy) and socio-economy. The relative risk of breast cancer after RA was assessed using Cox regression, and the relative risk of RA in women with a history of breast cancer was assessed using conditional logistic regression.ResultsThe risk of incident breast cancer in women with RA was reduced and the association was not attenuated by adjustment for breast cancer risk factors (HR=0.80, 95% CI 0.68 to 0.93). The risk of RA in women with a history of breast cancer was similarly reduced (OR=0.87, 95% CI 0.79 to 0.95). Women with breast cancer treated with tamoxifen (OR=0.86, 95% CI 0.62 to 1.20) or aromatase inhibitors (OR=0.97, 95% CI 0.69 to 1.37) did not have an increased risk of RA compared with women with breast cancer treated differently.ConclusionsThe decreased occurrence of breast cancer in patients with RA is present already before RA diagnosis; these reduced risks are not readily explained by hormonal risk factors. Adjuvant antihormonal therapy for breast cancer does not seem to increase RA risk.

Breast Cancer Risk Factors in Italian Women: A Multicentric Case-Control Study

1986 ◽  
Vol 72 (3) ◽  
pp. 241-249 ◽  
Author(s):  
Antonio Toti ◽  
Silvio Agugiaro ◽  
Dino Amadori ◽  
Gianfranco Buzzi ◽  
Paolo Bruzzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Family History ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Female Population ◽  
History Of ◽  
Control Study

To evaluate the importance of several risk factors for breast cancer in the Italian female population, a large multicentric case-control study was conducted in 10 breast clinics in Italy. The study included 1,556 women affected by breast cancer, histologically and/or cytologically confirmed. Controls were 1,505 women admitted to a hospital in the same town, matched with cases for residence and with the same age distribution of the Italian female population. The risk factors considered in this study were family history of breast cancer, reproductive history, height and weight, use of oral contraceptives, other hormonal therapies and smoking history. The results of this study confirm the significant role of a positive family history of breast cancer (RR = 2.37); the relative risk was even higher when a first-degree relative was affected or the breast cancer was bilateral. The analysis of the reproductive history showed a significant trend of increasing risk with increasing age at first birth and, although less evident, with increasing number of children. Quetelet's index (kg/m–2) was positively correlated with breast cancer risk, mostly in postmenopausal women. Among other studied factors, only late age at menopause confirmed an increased risk for breast cancer, whereas age at menarche, use of oral contraceptives and smoking histories did not show any significant correlation with breast cancer risk. These results are in substantial agreement with other international studies, but represent an interesting contribution to studies about the Italian female population.

Indicators of Lifetime Estrogen Exposure: Effect on Breast Cancer Incidence and Interaction With Raloxifene Therapy in the Multiple Outcomes of Raloxifene Evaluation Study Participants

2001 ◽  
Vol 19 (12) ◽  
pp. 3111-3116 ◽  
Author(s):  
Marc E. Lippman ◽  
Kathryn A. Krueger ◽  
Stephen Eckert ◽  
Andreas Sashegyi ◽  
Erin L. Walls ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Family History ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Estrogen Exposure ◽  
History Of ◽  
More Trial

PURPOSE: To test the hypothesis that risk factors related to lifetime estrogen exposure predict breast cancer incidence and to test if any subgroups experience enhanced benefit from raloxifene. PATIENTS AND METHODS: Postmenopausal women with osteoporosis (N = 7,705), enrolled onto the Multiple Outcomes of Raloxifene Evaluation (MORE) trial, were randomly assigned to receive placebo, raloxifene 60 mg/d, or raloxifene 120 mg/d for 4 years. Breast cancer risk was analyzed by the following baseline characteristics indicative of estrogen exposure: previous hormone replacement therapy, prevalent vertebral fractures, family history of breast cancer, estradiol level, bone mineral density (BMD), body mass index, and age at menopause. Therapy-by-subgroup interactions were assessed using a logistic regression model. RESULTS: Overall, women with the highest one-third estradiol levels (≥ 12 pmol/L) had a 2.07-fold increased invasive breast cancer risk compared with women with lower levels. Raloxifene significantly reduced breast cancer risk in both the low- and high-estrogen subgroups for all risk factors examined (P < .05 for each comparison). The women with the highest BMD and those with a family history of breast cancer experienced a significantly greater therapy benefit with raloxifene, compared with the two thirds of patients with lower BMD or those without a family history, respectively; the subgroup-by-therapy interactions were significant (P = .005 and P = .015, respectively). CONCLUSION: The MORE trial confirms that increased lifetime estrogen exposure increases breast cancer risk. Raloxifene therapy reduces breast cancer risk in postmenopausal osteoporotic women regardless of lifetime estrogen exposure, but the reduction is greater in those with higher lifetime exposure to estrogen.

scholarly journals Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Oana A. Zeleznik ◽  
Raji Balasubramanian ◽  
Yibai Zhao ◽  
Lisa Frueh ◽  
Sarah Jeanfavre ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Amino Acids ◽  
Amino Acid ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Kynurenic Acid ◽  
Conditional Logistic Regression ◽  
Premenopausal Women ◽  
Health Study

AbstractKnown modifiable risk factors account for a small fraction of premenopausal breast cancers. We investigated associations between pre-diagnostic circulating amino acid and amino acid-related metabolites (N = 207) and risk of breast cancer among predominantly premenopausal women of the Nurses’ Health Study II using conditional logistic regression (1057 cases, 1057 controls) and multivariable analyses evaluating all metabolites jointly. Eleven metabolites were associated with breast cancer risk (q-value < 0.2). Seven metabolites remained associated after adjustment for established risk factors (p-value < 0.05) and were selected by at least one multivariable modeling approach: higher levels of 2-aminohippuric acid, kynurenic acid, piperine (all three with q-value < 0.2), DMGV and phenylacetylglutamine were associated with lower breast cancer risk (e.g., piperine: ORadjusted (95%CI) = 0.84 (0.77–0.92)) while higher levels of creatine and C40:7 phosphatidylethanolamine (PE) plasmalogen were associated with increased breast cancer risk (e.g., C40:7 PE plasmalogen: ORadjusted (95%CI) = 1.11 (1.01–1.22)). Five amino acids and amino acid-related metabolites (2-aminohippuric acid, DMGV, kynurenic acid, phenylacetylglutamine, and piperine) were inversely associated, while one amino acid and a phospholipid (creatine and C40:7 PE plasmalogen) were positively associated with breast cancer risk among predominately premenopausal women, independent of established breast cancer risk factors.

scholarly journals Patients’ characteristics, Cytochrome P4501A1 genetic polymorphisms and breast cancer risk in Sudanese women

2021 ◽  
Vol 5 ◽  
Author(s):  
Fatima Hamad ◽  
Sulma I. Mohammed ◽  
Abdelrahim O. Mohamed ◽  
Dafalla O. Abuidris Elmustafa
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Small Sample Size ◽  
Menopausal Status ◽  
Premenopausal Women ◽  
Small Sample ◽  
Cancer History ◽  
Polycyclic Aromatic ◽  
History Of

Background: The CYP1A1 catalyses polycyclic aromatic hydrocarbons activation to reactive metabolites, causing deoxyribonucleic acid (DNA) damage and cancer. It is highly polymorphic and displays ethnic differences in various populations.Aim: To evaluate the association of three polymorphic variants in the CYP1A1 gene with breast cancer in Sudanese women.Sett ing: This is a case-control study.Methods: After consenting, the participants completed questionnaires consisting of sociodemographic data, gynaecological status, and breast cancer history. We recorded clinical data, weight, and height for each woman and drew blood for PCR and RFLP analyses for CYP1A1 genotyping.Results: The CYP1A1 M1 and CYP1A1 M3 genotypes and homozygous CYP1A1 M1 (C/C) and CYP1A1 M3 (C/C) genotypes are not associated with breast cancer risk and menopausal status in women. The homozygous CYP1A1 M2 (A/A) genotype had a significant association with a risk reduction of breast cancer in premenopausal women. In contrast, the heterozygous CYP1A1 M2 (A/G) and the homozygous (G/G) are associated with significant breast cancer risk.Conclusion: Despite the limitations encountered in this study that included the small sample size and availability of age-matched controls, the results suggest that the CYP1A1 M2 polymorphism, educational level, and family history of breast cancer may have an association with the risk of developing breast cancer amongst Sudanese women and warrant confirmation in more extensive studies.

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