scholarly journals Utility of Iron Staining in Identifying the Cause of Renal Allograft Dysfunction in Patients with Sickle Cell Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Yingchun Wang ◽  
Mona Doshi ◽  
Salman Khan ◽  
Wei Li ◽  
Ping L. Zhang
Keyword(s):  
Renal Transplant ◽  
Sickle Cell Disease ◽  
Renal Biopsy ◽  
Sickle Cell ◽  
Renal Allograft ◽  
Renal Tubules ◽  
Cell Disease ◽  
Allograft Dysfunction ◽  
Disease Case ◽  
Iron Heme

Sickle cell nephropathy (SCN) is associated with iron/heme deposition in proximal renal tubules and related acute tubular injury (ATI). Here we report the utility of iron staining in differentiating causes of renal allograft dysfunction in patients with a history of sickle cell disease. Case 1: the patient developed acute allograft dysfunction two years after renal transplant. Her renal biopsy showed ATI, supported by patchy loss of brush border and positive staining of kidney injury molecule-1 in proximal tubular epithelial cells, where diffuse increase in iron staining (2+) was present. This indicated that ATI likely resulted from iron/heme toxicity to proximal tubules. Electron microscope confirmed aggregated sickle RBCs in glomeruli, indicating a recurrent SCN. Case 2: four years after renal transplant, the patient developed acute allograft dysfunction and became positive for serum donor-specific antibody. His renal biopsy revealed thrombotic microangiopathy (TMA) and diffuse positive C4d stain in peritubular capillaries. Iron staining was negative in the renal tubules, implying that TMA was likely associated with acute antibody-mediated rejection (AAMR, type 2) rather than recurrent SCN. These case reports imply that iron staining is an inexpensive but effective method in distinguishing SCN-associated renal injury in allograft kidney from other etiologies.

P113 Hepatic sequestration crisis in sickle cell disease — case report

2003 ◽  
Vol 14 ◽  
pp. S64
Author(s):  
C. Rolao ◽  
F. Araújo ◽  
R. Simoes ◽  
F. Rego ◽  
J.L. DuclaSoares
Keyword(s):  
Case Report ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Disease Case

Hyperhemolysis syndrome in sickle cell disease: case report (recurrent episode) and literature review

Transfusion ◽  
2008 ◽  
Vol 48 (6) ◽  
pp. 1231-1238 ◽  
Author(s):  
Nay Win ◽  
Helen New ◽  
Edmond Lee ◽  
Josu de la Fuente
Keyword(s):  
Case Report ◽  
Sickle Cell Disease ◽  
Literature Review ◽  
Sickle Cell ◽  
Recurrent Episode ◽  
Cell Disease ◽  
Disease Case

scholarly journals Lupus Nephritis in a Patient with Sickle Cell Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Vinay Minocha ◽  
Fauzia Rana
Keyword(s):  
Sickle Cell Disease ◽  
Lupus Nephritis ◽  
Renal Biopsy ◽  
Sickle Cell ◽  
Lupus Erythematosus ◽  
Early Recognition ◽  
African American Female ◽  
Cell Disease ◽  
Diagnostic Challenge ◽  
Renal Abnormality

Introduction. The diagnosis of systemic lupus erythematosus (SLE) in patients with sickle cell disease (SCD) can be difficult to establish because the musculoskeletal, central nervous system, and renal manifestations are similar in both diseases. In the presented case, we highlight the diagnostic challenge that can evolve in patients with a concurrence of both diseases and we establish the importance of early recognition and treatment of lupus nephritis in patients with SCD.Case Presentation. We present a case of a 31-year-old African American female with sickle-C disease (hemoglobin SC) who was admitted to our hospital with complaints of periumbilical abdominal pain associated with intractable nausea and vomiting, abdominal distension, and worsening lower extremity edema. Urine studies revealed nephrotic range proteinuria and the immunological investigations were consistent with lupus. A renal biopsy revealed focal proliferative lupus nephritis.Conclusion. It is important to consider the presence of a coexisting autoimmune disease in a patient with sickle hemoglobinopathy who displays an atypical and multisystem presentation that is unresponsive to conventional therapies. When a significant kidney disease is present, a renal biopsy is critical in identifying the etiology of a renal abnormality in the setting of coexisting SLE and SCD.

scholarly journals Doença falciforme e o acompanhamento na atenção básica: relato de caso

2017 ◽  
Vol 4 (3) ◽  
pp. 47
Author(s):  
Daiana Márcia Melo Cruz ◽  
Seyna Ueno Rabelo Mendes ◽  
Bruno Sousa Pires
Keyword(s):  
Primary Care ◽  
Sickle Cell Disease ◽  
Health Service ◽  
Sickle Cell ◽  
Clinical Course ◽  
Recessive Inheritance ◽  
Cell Disease ◽  
Gradual Loss ◽  
Disease Case

No presente relato os autores descrevem um caso de Doença Falciforme em uma criança de 04 anos de idade destacando a importância do seu acompanhamento pela atenção básica. Essa doença decorre de uma mutação no gene que produz a hemoglobina A, originando outra, denominada hemoglobina S, de herança recessiva. O curso clínico é o de uma doença falciforme de intensidade menos grave. As crises hemolíticas são mais amenas. O baço está aumentado na criança, poedendo persistir na idade adulta. Além disso, há perda da função esplênica de forma gradual. O diagnóstico é realizado através da Eletroforese de Hemoglobina. A doença não tem cura, necessitando do acompanhamento regular do paciente pelo serviço de saúde para controle da doença e prevenção de complicações.   Palavras-chave: doença falciforme, hemoglobina, atenção básica. ABSTRACT There is no report and description of a Sickle Cell Disease case in a 4 years old child. highlighting the importance of their follow-up for primary care. This disease arises from a non-gene mutation that produces a hemoglobin A, originating another, called hemoglobin S, of recessive inheritance. The clinical course is a sickle cell disease of less severe severity. As hemolytic crises are milder. The spleen is increased in the child, and may persist in adulthood. In addition, there is gradual loss of splenic function. The diagnosis was made through Hemoglobin Electrophoresis. The disease has no cure, requiring regular monitoring by the health service to control the disease and prevent complications. Keywords: Sickle Cell Disease, hemoglobin, primary care.

Amputations in Sickle Cell Disease: Case Series and Literature Review

Hemoglobin ◽  
2016 ◽  
Vol 40 (3) ◽  
pp. 150-155 ◽  
Author(s):  
Claudia Maximo ◽  
Sara T. Olalla Saad ◽  
Eleonora Thome ◽  
Ana Maria Mach Queiroz ◽  
Clarisse Lobo ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Literature Review ◽  
Sickle Cell ◽  
Case Series ◽  
Cell Disease ◽  
Disease Case
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