scholarly journals Mediastinal Packing for Intractable Coagulopathy in Acute Aortic Dissection (Types 1 and 2 DeBakey): A Life-Saving Technique—Report of Experiences

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Aliasghar Moeinipour ◽  
Mehdi Fathi ◽  
Alireza Sepehri Shamloo ◽  
Shahram Amini ◽  
Hamid Hoseinikhah ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Life Saving ◽  
Cardiac Surgeons ◽  
Severe Coagulopathy

Nonsurgical bleeding after complex thoracic aortic procedures (such as aortic dissection and aortic aneurysm) is a great challenge for cardiac surgeons because of severe coagulopathy, exsanguinous bleeding, and inevitable death. Temporary mediastinal packing (with sponge) in such cases is the only life-saving technique with good result in most cases. Herein, we presented three cases with acute aortic dissection with intractable bleeding that was successfully managed with mediastinal packing.

A Case of Combined Acute Aortic Dissection and Abdominal Aortic Aneurysm with Hemolysis.

2002 ◽  
Vol 31 (3) ◽  
pp. 227-229
Author(s):  
Etsuro Suenaga ◽  
Kazuhisa Rikitake ◽  
Ryo Shiraishi ◽  
Tsuyoshi Itoh
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Abdominal Aortic

scholarly journals Aortic wall thickness in patients with ascending aortic aneurysm versus acute aortic dissection

2015 ◽  
Vol 49 (3) ◽  
pp. 756-762 ◽  
Author(s):  
Joeri Van Puyvelde ◽  
Eric Verbeken ◽  
Peter Verbrugghe ◽  
Paul Herijgers ◽  
Bart Meuris
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Wall Thickness ◽  
Aortic Wall ◽  
Acute Aortic Dissection ◽  
Ascending Aortic Aneurysm ◽  
Aortic Wall Thickness

Acute Aortic Dissection Involving a Fusiform Abdominal Aortic Aneurysm

1999 ◽  
Vol 33 (3) ◽  
pp. 341-345
Author(s):  
Paul E. Y. Van Schil ◽  
Inez E. R. Rodrigus ◽  
Luc R. D. Haenen ◽  
Filip Van den Brande ◽  
Rudolphe G. M. T. Vanmaele ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Abdominal Aortic

scholarly journals Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome

2021 ◽  
Author(s):  
Cristina I. Caescu ◽  
Jens Hansen ◽  
Brittany Crockett ◽  
Wenzhen Xiao ◽  
Pauline Arnaud ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Marfan Syndrome ◽  
Thoracic Aortic Aneurysm ◽  
Acute Aortic Dissection ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Aortic Disease ◽  
Computational Analyses

Objective: Despite considerable research, the goal of finding nonsurgical remedies against thoracic aortic aneurysm and acute aortic dissection remains elusive. We sought to identify a novel aortic protein kinase that can be pharmacologically targeted to mitigate aneurysmal disease in a well-established mouse model of early-onset progressively severe Marfan syndrome (MFS). Approach and Results: Computational analyses of transcriptomic data derived from the ascending aorta of MFS mice predicted a probable association between thoracic aortic aneurysm and acute aortic dissection development and the multifunctional, stress-activated HIPK2 (homeodomain-interacting protein kinase 2). Consistent with this prediction, Hipk2 gene inactivation significantly extended the survival of MFS mice by slowing aneurysm growth and delaying transmural rupture. HIPK2 also ranked among the top predicted protein kinases in computational analyses of genes differentially expressed in the dilated aorta of 3 MFS patients, which strengthened the clinical relevance of the experimental finding. Additional in silico analyses of the human and mouse data sets identified the TGF (transforming growth factor)-β/Smad3 signaling pathway as a potential target of HIPK2 in the MFS aorta. Chronic treatment of MFS mice with an allosteric inhibitor of HIPK2-mediated stimulation of Smad3 signaling validated this prediction by mitigating thoracic aortic aneurysm and acute aortic dissection pathology and partially improving aortic material stiffness. Conclusions: HIPK2 is a previously unrecognized determinant of aneurysmal disease and an attractive new target for antithoracic aortic aneurysm and acute aortic dissection multidrug therapy.

Acute Aortic Dissection: Population-Based Incidence Compared With Degenerative Aortic Aneurysm Rupture

2004 ◽  
Vol 79 (2) ◽  
pp. 176-180 ◽  
Author(s):  
W. Darrin Clouse ◽  
John W. Hallett ◽  
Hartzell V. Schaff ◽  
Peter C. Spittell ◽  
Charles M. Rowland ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Population Based ◽  
Aneurysm Rupture
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