Contrast-Enhanced Endoscopic Ultrasonography for Pancreatic Tumors

BioMed Research International ◽

10.1155/2015/491782 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 16

Author(s):

Yasunobu Yamashita ◽

Jun Kato ◽

Kazuki Ueda ◽

Yasushi Nakamura ◽

Yuki Kawaji ◽

...

Keyword(s):

Endoscopic Ultrasonography ◽

Early Phase ◽

Late Phase ◽

Fibrous Tissue ◽

Phase Correlation ◽

Pancreatic Tumors ◽

Phase Image ◽

Histological Differentiation ◽

Contrast Enhanced ◽

Phase Images

Objectives. To investigate the usefulness of contrast-enhanced endoscopic ultrasonography (CE-EUS) for histological differentiation of pancreatic tumors.Methods. CE-EUS was performed for consecutive patients having a pancreatic solid lesion, and tumors were classified into three vascular patterns (hypervascular, isovascular, and hypovascular) at two time phases (early-phase and late-phase). Correlation between vascular patterns and histopathology of resected pancreatic cancer (PC) tissues was ascertained.Results. The final diagnoses of 147 examined tumors were PC(n=109), inflammatory mass(n=11), autoimmune pancreatitis(n=9), neuroendocrine tumor(n=8), and others(n=10). In late-phase images, 104 of 109 PCs had the hypovascular pattern, for a diagnostic sensitivity and specificity of 94% and 71%, respectively. Of 28 resected PCs, 10 had isovascular, and 18 hypovascular, patterns on the early-phase image. Early-phase isovascular PCs were more likely to be differentiated than were early-phase hypovascular PCs (6 well and 4 moderately differentiated versus 3 well, 14 moderately, and 1 poorly differentiated,P=0.028). Immunostaining revealed that hypovascular areas of early-phase images reflected heterogeneous tumor cells with fibrous tissue, necrosis, and few vessels.Conclusion. CE-EUS could be useful for distinguishing PC from other solid pancreatic lesions and for histological differentiation of PCs.

Download Full-text

Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis

Japanese Journal of Radiology ◽

10.1007/s11604-013-0276-7 ◽

2014 ◽

Vol 32 (3) ◽

pp. 138-144 ◽

Cited By ~ 2

Author(s):

Tomohiro Kaneta ◽

Nobuyuki Okamura ◽

Akira Arai ◽

Kentaro Takanami ◽

Katsutoshi Furukawa ◽

...

Keyword(s):

Early Phase ◽

Late Phase ◽

Anatomical Standardization ◽

Phase Images

Download Full-text

T1455: Evaluation of Pancreatic Tumors With Contrast Enhanced-Endoscopic Ultrasonography and EUS-Strain Ratio Elastography

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2010.03.668 ◽

2010 ◽

Vol 71 (5) ◽

pp. AB281 ◽

Cited By ~ 6

Author(s):

Abdenor Badaoui ◽

Ivan Borbath ◽

Tarik Aouattah ◽

Cedric Gillain ◽

Thierry De Ronde ◽

...

Keyword(s):

Endoscopic Ultrasonography ◽

Strain Ratio ◽

Pancreatic Tumors ◽

Contrast Enhanced

Download Full-text

Characterization of Pancreatic Tumors with Quantitative Perfusion Analysis in Contrast-Enhanced Harmonic Endoscopic Ultrasonography

Oncology ◽

10.1159/000481231 ◽

2017 ◽

Vol 93 (1) ◽

pp. 55-60 ◽

Cited By ~ 11

Author(s):

Shunsuke Omoto ◽

Mamoru Takenaka ◽

Masayuki Kitano ◽

Takeshi Miyata ◽

Ken Kamata ◽

...

Keyword(s):

Endoscopic Ultrasonography ◽

Pancreatic Tumors ◽

Quantitative Perfusion ◽

Contrast Enhanced

Download Full-text

115 Improved Diagnosis of Liver Metastases Using Kupffer-Phase Image of Contrast-Enhanced Harmonic Endoscopic Ultrasonography in Patients With Pancreatic Cancer

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2017.03.049 ◽

2017 ◽

Vol 85 (5) ◽

pp. AB53 ◽

Cited By ~ 1

Author(s):

Kosuke Minaga ◽

Mamoru Takenaka ◽

Masayuki Kitano ◽

Hajime Imai ◽

Kentaro Yamao ◽

...

Keyword(s):

Pancreatic Cancer ◽

Liver Metastases ◽

Endoscopic Ultrasonography ◽

Phase Image ◽

Contrast Enhanced

Download Full-text

Tissue Harmonic versus Contrast‐Enhanced Harmonic Endoscopic Ultrasonography for the Diagnosis of Pancreatic Tumors: A Prospective Multicenter Study

Digestive Endoscopy ◽

10.1111/den.13944 ◽

2021 ◽

Author(s):

Shunsuke Omoto ◽

Masayuki Kitano ◽

Mitsuharu Fukasawa ◽

Reiko Ashida ◽

Hironari Kato ◽

...

Keyword(s):

Endoscopic Ultrasonography ◽

Multicenter Study ◽

Pancreatic Tumors ◽

Prospective Multicenter Study ◽

Contrast Enhanced

Download Full-text

Contrast-Enhanced Harmonic Endoscopic Ultrasonography in Pancreatic Diseases

Diagnostic and Therapeutic Endoscopy ◽

10.1155/2012/786239 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Can Xu ◽

Zhaoshen Li ◽

Michael Wallace

Keyword(s):

Endoscopic Ultrasonography ◽

Pancreatic Tumors ◽

Imaging Method ◽

Pancreatic Diseases ◽

Pancreatic Cancers ◽

Novel Technology ◽

Contrast Enhanced ◽

Pancreatic Masses ◽

Adequate Sampling ◽

Solid Lesions

Endoscopic ultrasonography (EUS) is the most sensitive imaging method for diagnosis of pancreatic tumors. However, it still has limits in the differentiation between pancreatic cancers and inflammatory tumor-like masses. A novel technology, contrast-enhanced harmonic EUS (CH-EUS), has been developed recently. It can visualize both parenchymal perfusion and microvasculature in pancreas without Doppler-related artifacts. Therefore, it is superior to EUS and CT in detecting small pancreatic masses and differential diagnosis of pancreatic masses. CH-EUS could be used for adequate sampling of pancreatic tumors and may predict the pathological features of the pancreatic solid lesions but still cannot replace EUS-FNA now.

Download Full-text

Anionic Contrast–Enhanced MicroCT Imaging Correlates with Biochemical and Histological Evaluations of Osteoarthritic Articular Cartilage

Cartilage ◽

10.1177/1947603520924748 ◽

2020 ◽

pp. 194760352092474

Author(s):

Candace Flynn ◽

Mark Hurtig ◽

Alex zur Linden

Keyword(s):

Apparent Density ◽

Early Phase ◽

Ex Vivo ◽

Late Phase ◽

Biochemical Properties ◽

Micro Computed Tomography ◽

Superficial Zone ◽

Contrast Enhanced

This study addressed difficulties in evaluating osteoarthritis (OA) progression in species with thin cartilage. Feasibility of using short, nonequilibrium contrast-enhanced micro–computed tomography (CE-μCT) to evaluate the physical and biochemical properties of cartilage was investigated. A preliminary in vitro study using CE-μCT study was performed using bovine osteochondral blocks with intact, mildly damaged (fibrillated), or severely damaged (delaminated) cartilage. Delamination of the superficial zone resulted in elevated apparent density compared with intact cartilage after 10 minutes of anionic contrast exposure ( P < 0.01). OA was induced by unilateral meniscal destabilization in n = 20 sheep divided into: early phase OA ( n = 9) and late phase OA ( n = 11), while n = 4 remained as naive controls. In vivo anionic nonequilibrium contrast CT of the operated stifle was conducted in the early phase sheep 13 weeks postoperatively using clinical resolution CT. Cartilage visibility in the contrasted leg was significantly improved compared with the noncontrasted contralateral stifle ( P < 0.05). Animals were sacrificed at 3 months (early phase) or 12 months (late phase) for additional ex vivo CE-μCT, and correlative tests with biochemical and histological measures. Concentration of sulfated glycosaminoglycan (sGAG) significantly varied between control, early, and late phase OA ( P < 0.005) and showed a negative ( r = −0.56) relationship with apparent density in the medial tibial plateau ( R2 = 0.28, P < 0.001). Histologically, parameters in proteoglycan and cartilage surface structure correlated with increasing attenuation. While previous studies have shown that CE-CT increases the apparent density of proteoglycan-depleted cartilage, we concluded that superficial zone disruption also contributes to this phenomenon.

Download Full-text

DIFFERENTIATION OF PANCREATIC CYSTS BY CONTRAST-ENHANCED ENDOSCOPIC ULTRASONOGRAPHY

10.1055/s-0038-1637205 ◽

2018 ◽

Author(s):

M Patricia Olar ◽

O Mosteanu ◽

I Rusu ◽

A Seicean

Keyword(s):

Endoscopic Ultrasonography ◽

Pancreatic Cysts ◽

Contrast Enhanced

Download Full-text

Improved Stage Categorization of PTZ-Induced Kindling and Late Enhanced Neurogenesis in PTZ Kindled Mice

10.31661/gmj.v8i0.1511 ◽

2019 ◽

Vol 8 ◽

pp. 1511

Author(s):

Marzieh Shahpari ◽

Hadi Aligholi ◽

Mohammad Reza Namavar ◽

Farzaneh Vafaee ◽

Masoumeh Emamghoreishi

Keyword(s):

Subventricular Zone ◽

Early Phase ◽

Hind Limb ◽

Late Phase ◽

The Other ◽

Myoclonic Jerk ◽

Ptz Kindling ◽

First Occurrence ◽

Tonic Extension ◽

Behavioral Index

Background: There is no universally accepted behavioral scoring to define the early development of phenothiazine (PTZ) kindling. Therefore, studies investigating alterations of neurogenesis in the PTZ model were mainly focused on full kindled animals rather than early stages of kindling. This study aimed to determine an appropriate behavioral index for categorizing stages of PTZ kindling progress and to evaluate neurogenesis during PTZ kindling. Materials and Methods: Twenty-four mice were intraperitoneally injected with a sub convulsive dose of PTZ (40mg/kg) every other day until they became full kindled. The first occurrence of different seizure behaviors and their durations were recorded during kindling development, and the different stages of kindling were categorized. Neurogenesis was evaluated in the lateral subventricular zone (SVZ) at each stage of kindling by immunofluorescence staining. Results: First occurrence of restlessness, motionless staring, hind limb tonic extension, Straub’s tail, myoclonic jerk, and tonic-clonic were sequentially observed in more than 80% of animals with increasing PTZ injections. The duration of the myoclonic jerk was significantly longer than the other seizure behaviors. The significantly higher percentage of BrdU-positive cells was found in SVZ of mice showing tonic-clonic in comparison to other seizure behaviors. Conclusion: A hierarchy behavior was observed during the kindling process when considering the first occurrence of seizure behaviors. We defined the first occurrence of restlessness, motionless, hind limb tonic extension and Straub’s tail behaviors as an early phase, myoclonic jerk as a borderline phase and tonic-clonic as a late phase of PTZ-induced kindling. Our results indicated an enhanced SVZ neurogenesis at the late phase of kindling. [GMJ.2019;8:e1511]

Download Full-text