scholarly journals The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Carolina Soekmadji ◽  
Colleen C. Nelson
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Advanced Prostate Cancer ◽  
Control Cell ◽  
Extracellular Vesicle ◽  
Multidrug Resistance Proteins ◽  
Acquired Drug Resistance ◽  
Resistance Proteins

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

The Role of Surfactants in the Reversal of Active Transport Mediated by Multidrug Resistance Proteins

2003 ◽  
Vol 92 (6) ◽  
pp. 1250-1261 ◽  
Author(s):  
Katrijn Bogman ◽  
Françoise Erne-Brand ◽  
Jochem Alsenz ◽  
Jürgen Drewe
Keyword(s):  
Multidrug Resistance ◽  
Active Transport ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins

The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis

2003 ◽  
Vol 65 (5) ◽  
pp. 765-771 ◽  
Author(s):  
Jan Hendrik Hooijberg ◽  
Godefridus J. Peters ◽  
Yehuda G. Assaraf ◽  
Ietje Kathmann ◽  
David G. Priest ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins ◽  
Folate Homeostasis

scholarly journals Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis

2015 ◽  
Vol 16 (S1) ◽  
Author(s):  
Robert M H Allen ◽  
Aniruthan Renukanthan ◽  
Kristen J Bubb ◽  
Inmaculada C Villar ◽  
Amie J Moyes ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Proteins ◽  
Vascular Homeostasis ◽  
Resistance Proteins

scholarly journals Unveiling the Role of Multidrug Resistance Proteins in Hypertension

Hypertension ◽  
2009 ◽  
Vol 54 (2) ◽  
pp. 210-216 ◽  
Author(s):  
João Marcos A. Delou ◽  
Aníbal G. Lopes ◽  
Márcia A.M. Capella
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins

scholarly journals Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)

2021 ◽  
Vol 12 ◽  
Author(s):  
José Pedro Gil ◽  
Cláudia Fançony
Keyword(s):  
Drug Resistance ◽  
Plasmodium Falciparum ◽  
Multidrug Resistance ◽  
Multi Drug Resistance ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins ◽  
Diverse Groups ◽  
Endogenous Substances

The capacity of the lethal Plasmodium falciparum parasite to develop resistance against anti-malarial drugs represents a central challenge in the global control and elimination of malaria. Historically, the action of drug transporters is known to play a pivotal role in the capacity of the parasite to evade drug action. MRPs (Multidrug Resistance Protein) are known in many phylogenetically diverse groups to be related to drug resistance by being able to handle a large range of substrates, including important endogenous substances as glutathione and its conjugates. P. falciparum MRPs are associated with in vivo and in vitro altered drug response, and might be important factors for the development of multi-drug resistance phenotypes, a latent possibility in the present, and future, combination therapy environment. Information on P. falciparum MRPs is scattered in the literature, with no specialized review available. We herein address this issue by reviewing the present state of knowledge.

scholarly journals Role of Multidrug Resistance Proteins in Nonresponders to Immunomodulatory Therapy for Noninfectious Uveitis

2020 ◽  
Vol 9 (5) ◽  
pp. 12
Author(s):  
Ravichandra Tagirasa ◽  
Khokan Rana ◽  
Hrishikesh Kaza ◽  
Debaprasad Parai ◽  
Santhoshkumar Damera ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Immunomodulatory Therapy ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins

scholarly journals Investigation of the Role of Multidrug Resistance Proteins (MRPs) in Vascular Homeostasis

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Robert Allen ◽  
Aniruthan Renukanthan ◽  
Kristen Bubb ◽  
Inmaculada Villar ◽  
Amie Moyes ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Resistance Proteins ◽  
Vascular Homeostasis ◽  
Resistance Proteins

Chemotherapy sensitivity recovery of prostate cancer cells by functional inhibition and knock down of multidrug resistance proteins

The Prostate ◽  
2011 ◽  
Vol 71 (16) ◽  
pp. 1810-1817 ◽  
Author(s):  
Catherine Sánchez ◽  
Alejandro Mercado ◽  
Héctor R. Contreras ◽  
Patricia Mendoza ◽  
Juan Cabezas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Multidrug Resistance Proteins ◽  
Prostate Cancer Cells ◽  
Chemotherapy Sensitivity ◽  
Resistance Proteins ◽  
Knock Down ◽  
Functional Inhibition
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