Chemotherapy sensitivity recovery of prostate cancer cells by functional inhibition and knock down of multidrug resistance proteins

The Prostate ◽  
2011 ◽  
Vol 71 (16) ◽  
pp. 1810-1817 ◽  
Author(s):  
Catherine Sánchez ◽  
Alejandro Mercado ◽  
Héctor R. Contreras ◽  
Patricia Mendoza ◽  
Juan Cabezas ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Multidrug Resistance Proteins ◽  
Prostate Cancer Cells ◽  
Chemotherapy Sensitivity ◽  
Resistance Proteins ◽  
Knock Down ◽  
Functional Inhibition

scholarly journals The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Carolina Soekmadji ◽  
Colleen C. Nelson
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Advanced Prostate Cancer ◽  
Control Cell ◽  
Extracellular Vesicle ◽  
Multidrug Resistance Proteins ◽  
Acquired Drug Resistance ◽  
Resistance Proteins

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

scholarly journals Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0131579 ◽  
Author(s):  
Lihong Mo ◽  
Vendula Pospichalova ◽  
Zhiqing Huang ◽  
Susan K. Murphy ◽  
Sturgis Payne ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins

Epothilone B Confers Radiation Dose Enhancement in DAB2IP Gene Knock-Down Radioresistant Prostate Cancer Cells

2010 ◽  
Vol 78 (4) ◽  
pp. 1210-1218 ◽  
Author(s):  
Zhaolu Kong ◽  
Pavithra Raghavan ◽  
Daxing Xie ◽  
Thomas Boike ◽  
Sandeep Burma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Dose ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Dose Enhancement ◽  
Knock Down ◽  
Epothilone B

Expression of multidrug resistance proteins in prostate cancer is related with cell sensitivity to chemotherapeutic drugs

The Prostate ◽  
2009 ◽  
Vol 69 (13) ◽  
pp. 1448-1459 ◽  
Author(s):  
Catherine Sánchez ◽  
Patricia Mendoza ◽  
Héctor R. Contreras ◽  
Jorge Vergara ◽  
James A. McCubrey ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Multidrug Resistance ◽  
Chemotherapeutic Drugs ◽  
Multidrug Resistance Proteins ◽  
Cell Sensitivity ◽  
Resistance Proteins
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