scholarly journals Synthesis and Biological Activity of Arylspiroborate Salts Derived from Caffeic Acid Phenethyl Ester

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Martin J. G. Hébert ◽  
Andrew J. Flewelling ◽  
Trevor N. Clark ◽  
Natalie A. Levesque ◽  
Jacques Jean-François ◽  
...  
Keyword(s):  
Biological Activity ◽  
Caffeic Acid ◽  
Radical Scavenging ◽  
Antimicrobial Properties ◽  
Caffeic Acid Phenethyl Ester ◽  
Boron Compounds ◽  
Biological Assays ◽  
Radical Scavenging Ability ◽  
New Compounds ◽  
Human Polymorphonuclear Leukocytes

Two novel boron compounds containing caffeic acid phenethyl ester (CAPE) derivatives have been prepared and characterized fully. These new compounds and CAPE have been investigated for potential antioxidant and antimicrobial properties and their ability to inhibit 5-lipoxygenase and whether chelation to boron improves their biological activity. Sodium salt 4 was generally more active than ammonium salt 5 in the biological assays and surpassed the radical scavenging ability of CAPE. Compounds 4 and 5 were more active than CAPE and Zileuton in human polymorphonuclear leukocytes. These results clearly show the effectiveness of the synthesized salts as transporter of CAPE.

Preparation of Caffeic Acid Phenethyl Ester-Incorporated Nanoparticles and Their Biological Activity

2015 ◽  
Vol 104 (1) ◽  
pp. 144-154 ◽  
Author(s):  
Hyo-Young Lee ◽  
Young-Il Jeong ◽  
Eun Jin Kim ◽  
Kyung Dong Lee ◽  
Seon-Hee Choi ◽  
...  
Keyword(s):  
Biological Activity ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester

scholarly journals Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31833 ◽  
Author(s):  
Luc H. Boudreau ◽  
Jacques Maillet ◽  
Luc M. LeBlanc ◽  
Jacques Jean-François ◽  
Mohamed Touaibia ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Polymorphonuclear Leukocytes ◽  
Caffeic Acid Phenethyl Ester ◽  
Human Polymorphonuclear Leukocytes

scholarly journals Constituents of Erythrina lysistemon: Their Brine Shrimp Lethality, Antimicrobial and Radical Scavenging Activities

2006 ◽  
Vol 1 (2) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Benard F. Juma ◽  
Runner R. T. Majinda
Keyword(s):  
Radical Scavenging ◽  
Dienoic Acid ◽  
Stem Bark ◽  
Artemia Salina ◽  
Moderate Activity ◽  
Stem Wood ◽  
Brine Shrimps ◽  
Weak Activity ◽  
Radical Scavenging Ability ◽  
New Compounds

Three new compounds, 4′,7-dihydroxy-2″,2″-dimethylpyrano [5″,6″: 5,6]-isoflavone (1), (7 E) (8,2′)-3,7,9,5′,9′-pentahydroxy-4,4′-dimethoxyneolign-7-ene (2) and (9 E,11 Z) 14-hydroxyoctadecan-9,11-dienoic acid (3), along with other known flavonoids, benzenoids, alkaloids and phenylpropanoids were isolated from the twigs, leaves, stem bark, stem wood and flowers of Erythrina lysistemon. Their structures were established on the basis of spectroscopic evidence. Some of these compounds have shown high lethality against brine shrimps ( Artemia salina), moderate radical scavenging ability in the DPPH assay, moderate antifungal activity against Candida mycoderma, moderate activity against the Gram-positive ( Bacillus subtilis and Staphylococcus aureus) and weak activity against Gram-negative bacteria ( Escherichia coli).

scholarly journals Synthesis of 1,4-benzothiazinones from acylpyruvic acids or furan-2,3-diones and o-aminothiophenol

2020 ◽  
Vol 16 ◽  
pp. 2322-2331
Author(s):  
Ekaterina E Stepanova ◽  
Maksim V Dmitriev ◽  
Andrey N Maslivets
Keyword(s):  
Biological Activity ◽  
Acute Toxicity ◽  
Synthetic Approach ◽  
Biological Assays ◽  
Synthetic Approaches ◽  
New Compounds

Two synthetic approaches to enaminones fused to 1,4-benzothiazin-2-one moiety, which can be interesting in studies on biological activity, chemosensors, and fluorescence, were developed via the reaction of furan-2,3-diones or acylpyruvic acids in the presence of carbodiimides with o-aminothiophenols. The target enaminones were formed together with pharmaceutically interesting 2-hydroxy-2H-1,4-benzothiazin-3(4H)-ones. A selective synthetic approach to 2-hydroxy-2H-1,4-benzothiazin-3(4H)-ones was developed via the solvent-switchable reaction of furan-2,3-diones with o-aminothiophenol. Preliminary biological assays (antimicrobial, acute toxicity) of the new compounds were carried out.

scholarly journals Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes

2014 ◽  
Vol 5 ◽  
pp. 2316-2325 ◽  
Author(s):  
Marcela Elisabeta Barbinta-Patrascu ◽  
Stefan Marian Iordache ◽  
Ana Maria Iordache ◽  
Nicoleta Badea ◽  
Camelia Ungureanu
Keyword(s):  
Carbon Nanotubes ◽  
Zeta Potential ◽  
Lipid Bilayers ◽  
Physical Stability ◽  
Radical Scavenging ◽  
Antimicrobial Properties ◽  
Lipid Vesicles ◽  
Original Design ◽  
Artificial Lipid Bilayers ◽  
Radical Scavenging Ability

In the last decade, building biohybrid materials has gained considerable interest in the field of nanotechnology. This paper describes an original design for bionanoarchitectures with interesting properties and potential bioapplications. Multilamellar lipid vesicles (obtained by hydration of a dipalmitoyl phosphatidylcholine thin film) with and without cholesterol were labelled with a natural photopigment (chlorophyll a), which functioned as a sensor to detect modifications in the artificial lipid bilayers. These biomimetic membranes were used to build non-covalent structures with single-walled carbon nanotubes. Different biophysical methods were employed to characterize these biohybrids such as: UV–vis absorption and emission spectroscopy, zeta potential measurements, AFM and chemiluminescence techniques. The designed, carbon-based biohybrids exhibited good physical stability, good antioxidant and antimicrobial properties, and could be used as biocoating materials. As compared to the cholesterol-free samples, the cholesterol-containing hybrid structures demonstrated better stability (i.e., their zeta potential reached the value of −36.4 mV), more pronounced oxygen radical scavenging ability (affording an antioxidant activity of 73.25%) and enhanced biocidal ability, offering inhibition zones of 12.4, 11.3 and 10.2 mm in diameter, against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis, respectively.

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