scholarly journals Retracted: Microwave Mediated Organic Reaction: A Convenient Approach for Rapid and Efficient Synthesis of Biologically Active Substituted 1,3-Dihydro-2H-indol-2-one Derivatives

2015 ◽  
Vol 2015 ◽  
pp. 1-1
Keyword(s):  
Biologically Active ◽  
Efficient Synthesis ◽  
Organic Reaction ◽  
Convenient Approach

scholarly journals Cover Picture: Biologically Active Compounds through Catalysis: Efficient Synthesis ofN-(Heteroarylcarbonyl)-N′-(arylalkyl)piperazines (Chem. Eur. J. 3/2004)

2004 ◽  
Vol 10 (3) ◽  
pp. 563-563
Author(s):  
Kamal Kumar ◽  
Dirk Michalik ◽  
Ivette Garcia Castro ◽  
Annegret Tillack ◽  
Alexander Zapf ◽  
...  
Keyword(s):  
Biologically Active Compounds ◽  
Biologically Active ◽  
Efficient Synthesis ◽  
Active Compounds

Biologically Active Compounds through Catalysis: Efficient Synthesis ofN-(Heteroarylcarbonyl)-N′-(arylalkyl)piperazines

2004 ◽  
Vol 10 (3) ◽  
pp. 746-757 ◽  
Author(s):  
Kamal Kumar ◽  
Dirk Michalik ◽  
Ivette Garcia Castro ◽  
Annegret Tillack ◽  
Alexander Zapf ◽  
...  
Keyword(s):  
Biologically Active Compounds ◽  
Biologically Active ◽  
Efficient Synthesis ◽  
Active Compounds

scholarly journals An Efficient Synthesis of Tetrodotoxin

2021 ◽  
Author(s):  
David Konrad ◽  
Peter Ruehmann ◽  
Hiroyasu Ando ◽  
Belinda Hetzler ◽  
Bryan Matsuura ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Stereoselective Synthesis ◽  
Primary Alcohol ◽  
Biologically Active ◽  
Dipolar Cycloaddition ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
Ready Access ◽  
Biologically Active Derivatives ◽  
Glucose Derivative

Tetrodotoxin (TTX) is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and one of the most celebrated targets of synthetic chemistry. Here, we present a stereoselective synthesis of TTX that proceeds in 22 steps starting from a readily available glucose derivative. The central cyclohexane ring of TTX and its α-tertiary amine moiety was established via the intramolecular 1,3-dipolar cycloaddition of a nitrile oxide, followed by alkynyl addition to the resultant isoxazoline. After some carefully chosen protecting group manipulations, a ruthenium-catalyzed hydroxylactonization set the stage for the formation of its dioxa-adamantane core. Installation of the guanidine, oxidation of a primary alcohol, and late-stage epimerization of the resultant aldehyde gave a mixture of TTX and anhydro TTX. Our synthesis represents one of the most effective of TTX reported to date and could give ready access to biologically active derivatives.

Triflic acid-catalyzed metal-free synthesis of (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones

2018 ◽  
Vol 42 (8) ◽  
pp. 6433-6440 ◽  
Author(s):  
Bapurao D. Rupanwar ◽  
Santosh S. Chavan ◽  
Anil M. Shelke ◽  
Gurunath M. Suryavanshi
Keyword(s):  
Biologically Active ◽  
Efficient Synthesis ◽  
Triflic Acid ◽  
Metal Free ◽  
Highly Efficient ◽  
Acid Catalyzed

A TfOH-catalyzed highly efficient synthesis of biologically active (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones has been reported with 64–94% yields under metal-free conditions.

Microwave-accelerated and efficient synthesis of structurally diverse N-(2,2-diphenylvinyl)-β-oxoamides

2021 ◽  
Author(s):  
Xingpeng Chen ◽  
Yelong Lei ◽  
Duo Fu ◽  
Jiaxi Xu
Keyword(s):  
Ring Opening ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Efficient Synthesis ◽  
Active Compounds ◽  
Dicarbonyl Compounds ◽  
Synthetic Intermediates

N-(2,2-Diphenylvinyl)-β-oxoamides are both the structural moiety of biologically active compounds and important synthetic intermediates. Structurally diverse N-(2,2-diphenylvinyl)-β-oxoamides are prepared efficiently from 2-diazo-1,3-dicarbonyl compounds and N-alkyl-2,2-diphenylaziridines via an electrophilic ring opening...

Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis

Tetrahedron ◽  
2014 ◽  
Vol 70 (42) ◽  
pp. 7686-7690 ◽  
Author(s):  
Qingfei Zheng ◽  
Shoufeng Wang ◽  
Wen Liu
Keyword(s):  
Biologically Active ◽  
Efficient Synthesis
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