ChemInform Abstract: An Efficient Synthesis of β,γ,γ-Trisubstituted-α-diethoxyphosphoryl-γ -lactams: A Convenient Approach to α-Methylene-γ-lactams.

ChemInform ◽  
2013 ◽  
Vol 44 (39) ◽  
pp. no-no
Author(s):  
Dariusz Deredas ◽  
Lukasz Albrecht ◽  
Henryk Krawczyk
Keyword(s):  
Efficient Synthesis ◽  
Convenient Approach

ChemInform Abstract: Mild and Efficient Synthesis of Benzo-Fused Seven- and Eight-Membered Ring Lactams: A Convenient Approach to Biologically Interesting Chemotypes.

ChemInform ◽  
2013 ◽  
Vol 44 (31) ◽  
pp. no-no
Author(s):  
Jayne L. Kenwright ◽  
Warren R. J. D. Galloway ◽  
Lars Wortmann ◽  
David R. Spring
Keyword(s):  
Membered Ring ◽  
Efficient Synthesis ◽  
Convenient Approach

Mild and Efficient Synthesis of Benzo-Fused Seven- and Eight-membered Ring Lactams: A Convenient Approach to Biologically Interesting Chemotypes

2013 ◽  
Vol 43 (11) ◽  
pp. 1508-1516 ◽  
Author(s):  
Jayne L. Kenwright ◽  
Warren R. J. D. Galloway ◽  
Lars Wortmann ◽  
David R. Spring
Keyword(s):  
Membered Ring ◽  
Efficient Synthesis ◽  
Convenient Approach

Discovery of fused azetidines as novel selective α4β2 neuronal nicotinic receptor (NNR) agonists

2005 ◽  
Vol 77 (12) ◽  
pp. 2041-2045 ◽  
Author(s):  
Jianguo Ji ◽  
William H. Bunnelle ◽  
Tao Li ◽  
Jennifer M. Pace ◽  
Michael R. Schrimpf ◽  
...  
Keyword(s):  
Trifluoroacetic Acid ◽  
Nicotinic Receptor ◽  
Ring Opening ◽  
Ethyl Carbamate ◽  
Dipolar Cycloaddition ◽  
Efficient Synthesis ◽  
Enantiomerically Pure ◽  
Neuronal Nicotinic Receptor ◽  
Ring Opening Reaction ◽  
Convenient Approach

An efficient synthesis of (1R,5S)-6-(5-cyano-3-pyridinyl)-3,6-diaza-bicyclo[3.2.0]heptane A-366833, a novel potent selective neuronal nicotinic receptor (NNR) agonist, is described. The enantiomerically pure pharmacophore benzyl (1S,5S)-3,6-diaza-bicyclo[3.2.0]heptane-3-carbamate was successfully constructed from benzyl N-allyl-N-(2-hydroxyimino-ethyl)-carbamate through a convenient approach including an intramolecular [1,3]-dipolar cycloaddition, reductive ring-opening reaction, chiral resolution, and intramolecular cyclization. Subsequent N-arylation of the pharmacophore with 3-bromo-5-cyanopyridine and N-Cbz deprotection with trifluoroacetic acid furnished A-366833.

scholarly journals Convenient and efficient synthesis of novel 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones derived from 2-bromo-(2/3-substitutedphenyl)-1H-indene-1,3(2H)-diones

RSC Advances ◽  
2019 ◽  
Vol 9 (23) ◽  
pp. 12784-12792
Author(s):  
Satbir Mor ◽  
Suchita Sindhu
Keyword(s):  
Efficient Synthesis ◽  
Metal Free ◽  
Convenient Approach

A metal-free and convenient approach to the synthesis of novel 11H-benzo[5,6][1,4]thiazino[3,4-a]isoindol-11-ones (5) is described.

A new facile and efficient synthesis of trans-(+)-sobrerol by biotransformation of α-pinene using extremophiles microorganisms

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
LA Vilaseca ◽  
J Quillaguamán ◽  
L Fuentes ◽  
O Sterner
Keyword(s):  
Efficient Synthesis
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