scholarly journals Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Tatiana Lauxen Peruzzolo ◽  
Mauricio Anes ◽  
Andre de Moura Kohmann ◽  
Ana Claudia Mércio Loredo Souza ◽  
Ramiro Borges Rodrigues ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Children And Adolescents ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Hippocampal Volume ◽  
Pediatric Bipolar Disorder ◽  
Control Group ◽  
Drug Naïve ◽  
Short Time ◽  
The Brain

Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm3, respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescents. Besides studies with larger sample sizes to confirm the present findings and longitudinal assessments, addressing brain development versus a control group and including drug-naive patients in different mood states may help clarify the role of BDNF in the brain changes consequent upon BD.

Brain-Derived Neurotrophic Factor in Children and Adolescents with Cirrhosis Due to Biliary Atresia

2016 ◽  
Vol 69 (1) ◽  
pp. 1-8
Author(s):  
Maria Inês A. Wilasco ◽  
Carolina Uribe-Cruz ◽  
Daniele Santetti ◽  
Bianca Pfaffenseller ◽  
Cristina T.L. Dornelles ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Biliary Atresia ◽  
Children And Adolescents ◽  
Neurotrophic Factor ◽  
Energy Homeostasis ◽  
Standard Deviation Score ◽  
Brain Derived Neurotrophic Factor ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Age Ratio

Background: The nutritional status in patients with cirrhosis is not so easy to assess properly. Considering the relationship between brain-derived neurotrophic factor (BDNF) and energy homeostasis, the main aim of this study was to evaluate the concentration of BDNF in children and adolescents with cirrhosis due to biliary atresia (BA) and correlate it with their nutritional status. Methods: Fifty-three children and adolescents with cirrhosis due to BA and 33 healthy controls were enrolled in this study. Nutritional status was evaluated using anthropometric parameters, and serum BDNF was measured by ELISA. Spearman coefficient was used to evaluate the correlation between variables. Results: In the cirrhosis group, 28.8% were undernourished and in the control group, 100% were well-nourished. BDNF median values for the control and cirrhosis group were 28.5 and 9.0 pg/ml respectively. BDNF and platelets were positively associated with both Standard Deviation Score (SDS) for height-for-age ratio and SDS for triceps skinfold thickness-for-age ratio. Conclusions: Considering these associations, BDNF may be an indirect biomarker of nutritional status in children and adolescents with chronic liver disease. Further studies must be conducted to clarify the role of BDNF in this population.

Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder

2010 ◽  
Vol 125 (1-3) ◽  
pp. 345-349 ◽  
Author(s):  
Georgina M. Hosang ◽  
Rudolf Uher ◽  
Robert Keers ◽  
Sarah Cohen-Woods ◽  
Ian Craig ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Life Events ◽  
Neurotrophic Factor ◽  
Stressful Life Events ◽  
Brain Derived Neurotrophic Factor ◽  
Stressful Life ◽  
Factor Gene ◽  
The Brain

Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder

2003 ◽  
Vol 337 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Kenji Nakata ◽  
Hiroshi Ujike ◽  
Ayumu Sakai ◽  
Naohiko Uchida ◽  
Akira Nomura ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
The Brain

scholarly journals Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes

2008 ◽  
Vol 30 (3) ◽  
pp. 243-245 ◽  
Author(s):  
Flávio Kapczinski ◽  
Benício N Frey ◽  
Ana C Andreazza ◽  
Márcia Kauer-Sant'Anna ◽  
Ângelo B M Cunha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Thiobarbituric Acid ◽  
Brain Derived Neurotrophic Factor ◽  
Oxidative Status ◽  
Control Group ◽  
Healthy Controls ◽  
Thiobarbituric Acid Reactive Substances ◽  
Low Levels

OBJECTIVE AND METHOD: There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder. In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress, we have examined the correlation between serum thiobarbituric acid reactive substances, a measure of lipid peroxidation, and serum brain-derived neurotrophic factor levels in bipolar disorder patients during acute mania and in healthy controls. RESULTS: Serum thiobarbituric acid reactive substances and brain-derived neurotrophic factor levels were negatively correlated in bipolar disorder patients (r = -0.56; p = 0.001), whereas no significant correlation was observed in the control group.. CONCLUSION: These results suggest that alterations in oxidative status may be mechanistically associated with abnormal low levels of brain-derived neurotrophic factor observed in individuals with bipolar disorder.

Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene

2011 ◽  
Vol 13 (7-8) ◽  
pp. 630-637 ◽  
Author(s):  
Catherine Sears ◽  
David Markie ◽  
Robin Olds ◽  
Alison Fitches
Keyword(s):  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
The Brain

scholarly journals The Brain-Derived Neurotrophic Factor Gene Confers Susceptibility to Bipolar Disorder: Evidence from a Family-Based Association Study

2002 ◽  
Vol 71 (3) ◽  
pp. 651-655 ◽  
Author(s):  
Maria Neves-Pereira ◽  
Emanuela Mundo ◽  
Pierandrea Muglia ◽  
Nicole King ◽  
Fabio Macciardi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Factor Gene ◽  
Family Based ◽  
The Brain
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