Positive association between the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder in the Han Chinese population

2009 ◽  
Vol 9999B ◽  
pp. n/a-n/a ◽  
Author(s):  
Jie Xu ◽  
Yun Liu ◽  
Peng Wang ◽  
Sheng Li ◽  
Yabing Wang ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Chinese Population ◽  
Positive Association ◽  
Brain Derived Neurotrophic Factor ◽  
Han Chinese ◽  
Bdnf Gene ◽  
Han Chinese Population ◽  
The Brain

Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder

2003 ◽  
Vol 337 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Kenji Nakata ◽  
Hiroshi Ujike ◽  
Ayumu Sakai ◽  
Naohiko Uchida ◽  
Akira Nomura ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
The Brain

Evidence of associations between bipolar disorder and the brain-derived neurotrophic factor (BDNF) gene

2011 ◽  
Vol 13 (7-8) ◽  
pp. 630-637 ◽  
Author(s):  
Catherine Sears ◽  
David Markie ◽  
Robin Olds ◽  
Alison Fitches
Keyword(s):  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
The Brain

Association between the brain-derived neurotrophic factor (BDNF) gene and Schizophrenia in the Chinese population

2006 ◽  
Vol 397 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Qing-Ying Chen ◽  
Qi Chen ◽  
Guo-Yin Feng ◽  
Chun-Ling Wan ◽  
Klaus Lindpaintner ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Chinese Population ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
The Brain

scholarly journals Brain-derived neurotrophic factor (BDNF) gene and rapid-cycling bipolar disorder

2006 ◽  
Vol 189 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Daniel J. Müller ◽  
Vincenzo De Luca ◽  
Tricia Sicard ◽  
Nicole King ◽  
John Strauss ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Rapid Cycling ◽  
Nucleotide Polymorphisms ◽  
Bdnf Gene ◽  
Single Nucleotide ◽  
Nuclear Families ◽  
Family Based ◽  
The Brain

BackgroundWe have previously reported the Val66Met and GT(n) repeat polymorphisms of the brain-derived neurotrophic factor (BDNF) gene to be associated with bipolar disorder. However, these findings have not been replicated consistently.AimsTo dissect the association of the BDNF gene with bipolar disorder by examining additional markers at the DNA level and by testing the illness categories of bipolar disorder I and II and rapid cycling.MethodWe performed a family-based association study and haplotype analyses with 312 nuclear families using four single nucleotide polymorphisms (SNPs) and the Val66Met and GT(n) repeat polymorphisms.ResultsThe SNPs hCVI1592756 and rs2049045, the Val66Met and GT(n) were significantly associated with bipolar disorder using transmission disequilibrium analyses (P=0.02, 0.009, 0.001 and 0.008 respectively). The effect at these markers was mainly driven by the rapid-cycling patients.ConclusionsWithin bipolar disorder, variation in the BDNF gene appears to predict risk for developing rapid cycling according to DSM–IV. Incorporating this clinical sub-phenotyping into other studies of the BDNF gene may help to resolve some of the inconsistencies reported thus far concerning BDNF and bipolar disorder.

Brain-Derived Neurotrophic Factor Systemic Response in the Periodontium, Trigeminal Nucleus Caudalis, and Hippocampus Induced by Occlusal Trauma

2021 ◽  
Vol 17 (7) ◽  
pp. 1371-1379
Author(s):  
Di Liu ◽  
Ying Li ◽  
Jiechen Liu ◽  
Zhiyuan Shen ◽  
Fengying Wang ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Systemic Response ◽  
Periodontal Tissue ◽  
Trigeminal Nucleus ◽  
Bdnf Gene ◽  
Dental Tissue ◽  
Injury And Repair ◽  
Activity Dependent ◽  
The Brain

Occlusal trauma (OT), by causing periodontal tissue damage, can activate and enhance the activity of the peripheral and central nervous system (CNS) neuropeptides. The brain-derived neurotrophic factor (BDNF) gene is activity-dependent and exhibits marked alterations, characterized by protection against injury and repair. Our results show the possible molecular mechanism through which noxious environmental stimuli induce alterations in BDNF activity in the local periodontal tissue, the primary sensory neurons-Vc, and the hippocampus, suggesting systemic impairment. BDNF serves a more positive and enduring trauma protection and repair function in Vc compared to that in local dental tissue.

Stressful life events and the brain-derived neurotrophic factor gene in bipolar disorder

2010 ◽  
Vol 125 (1-3) ◽  
pp. 345-349 ◽  
Author(s):  
Georgina M. Hosang ◽  
Rudolf Uher ◽  
Robert Keers ◽  
Sarah Cohen-Woods ◽  
Ian Craig ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Life Events ◽  
Neurotrophic Factor ◽  
Stressful Life Events ◽  
Brain Derived Neurotrophic Factor ◽  
Stressful Life ◽  
Factor Gene ◽  
The Brain
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