scholarly journals Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements amongHFEC282Y Homozygotes

2015 ◽  
Vol 2015 ◽  
pp. 1-9
Author(s):  
Seyed Ali Mousavi ◽  
Faiza Mahmood ◽  
Astrid Aandahl ◽  
Teresa Risopatron Knutsen ◽  
Abid Hussain Llohn
Keyword(s):  
Correlation Analysis ◽  
Serum Ferritin ◽  
Transferrin Saturation ◽  
Hemoglobin Level ◽  
Iron Depletion ◽  
Bivariate Correlation ◽  
Treatment Characteristics ◽  
Relationship Of ◽  
Baseline Hemoglobin

Objectives. We aimed to examine whether baseline hemoglobin levels in C282Y-homozygous patients are related to the degree of serum ferritin (SF) elevation and whether patients with different baseline hemoglobin have different phlebotomy requirements.Methods. A total of 196 patients (124 males and 72 females) who had undergone therapeutic phlebotomy and had SF and both pre- and posttreatment hemoglobin values were included in the study.Results. Bivariate correlation analysis suggested that baseline SF explains approximately 6 to 7% of the variation in baseline hemoglobin. The results also showed that males who had higher (≥150 g/L) baseline hemoglobin levels had a significantly greater reduction in their posttreatment hemoglobin despite requiring fewer phlebotomies to achieve iron depletion than those who had lower (<150 g/L) baseline hemoglobin, regardless of whether baseline SF was below or above 1000 µg/L. There were no significant differences between hemoglobin subgroups regarding baseline and treatment characteristics, except for transferrin saturation between male subgroups with SF above 1000 µg/L. Similar differences were observed when females with higher (≥138 g/L) baseline hemoglobin were compared with those with lower (<138 g/L) baseline hemoglobin.Conclusion. Dividing C282Y-homozygous patients into just two subgroups according to the degree of baseline SF elevation may obscure important subgroup variations.

scholarly journals Correlation between vivax malaria infection and iron deficiency in children

2015 ◽  
Vol 55 (1) ◽  
pp. 44
Author(s):  
Desmansyah Desmansyah ◽  
Rini Purnamasari ◽  
Theodorus Theodorus ◽  
Sulaiman Waiman
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Vivax Malaria ◽  
Malaria Infection ◽  
Serum Iron ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Hemoglobin Level ◽  
Ferritin Concentration ◽  
Iron Deficient

Background Iron deficiency is considered to be a major public health problem around the world due to its high prevalence as well as its effect on growth, development, and infection-resistance in children. In malaria-endemic areas, malaria infection is thought to contribute to the occurrence of iron deficiency, by means of hepcidin and hemolysis mechanisms. Objective To assess the prevalence of asymptomatic vivax malaria, compare hemoglobin levels and iron status parameters between vivax malaria-infected and uninfected children, assess the prevalence of iron deficiency, and evaluate a possible correlation between vivax malaria infection and iron deficiency. Methods This cross-sectional study was conducted from February to April 2013 at Sanana City of Sula Islands District, North Maluku. Six parameters were evaluated in 5-11-year-old children: malaria parasite infection, hemoglobin level, serum iron concentration, total iron-binding capacity (TIBC), serum transferrin saturation, and serum ferritin concentration. Results Among 296 children aged 5-11 years, 75 (25.3%) were infected with Plasmodium vivax. In infected children, hemoglobin, serum iron, transferrin saturation, TIBC and serum ferritin were significantly lower than in non-infected children (P<0.01). Using a serum ferritin cut-off of <15 μg/dL, 142 (48.0%) of the children were found to be iron deficient. There was a strong correlation between vivax malaria infection and iron deficiency (OR 3.573; 95%CI 2.03-6.29). ConclusionThe prevalence of asymptomatic vivax malaria infection was 25.3%. The hemoglobin level and iron status parameters in vivax malaria-infected subjects were significantly lower than in uninfected children. The prevalence of iron deficiency was 48.0% for all study subjects. Malaria vivax infection was correlated with iron deficiency in 5-11-year-old children at Sanana City.

Elevated MCV in Patients with Hereditary Hemochromatosis.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3733-3733
Author(s):  
Sameh E. Mikhail ◽  
Pradyumna D. Phatak
Keyword(s):  
Serum Ferritin ◽  
Hereditary Hemochromatosis ◽  
Transferrin Saturation ◽  
Serum Transferrin ◽  
Weak Correlation ◽  
The Mean ◽  
Relationship Of ◽  
The Relationship ◽  
Hfe Mutation ◽  
C282y Hfe Mutation

Abstract Background: Previous studies have reported that patients with Hereditary Hemochromatosis have higher red cell volumes than normal controls. The relationship of this abnormality to the degree of iron overload and to HFE genotype has not been systematically studied. Method: We retrospectively compared the mean corpuscular volume (MCV) of patients with Hereditary Hemochromatosis with that of an age-, race- and sex-matched control population from the primary care clinic at our institution. We studied the relationship of MCV at diagnosis with serum transferrin saturation, serum ferritin level, phlebotomy-mobilizable iron stores and HFE genotype in our patients. Results: The study population included 290 patients who were treated for Hereditary Hemochromatosis at our center. 122/290 were homozygous for C282Y; the mean MCV of this group was significantly elevated at 95.2 fL (control group was 89.2 fL; p<0.001) Among all patients with phlebotomy-mobilizable iron greater than four grams, regardless of HFE genotype, the mean MCV was 94.8 fL (significantly greater than control, p<0.001); there was no significant difference between those who are homozygous for the C282Y HFE mutation and those who are not. Among C282Y homozygous individuals, there was no significant correlation between the MCV versus serum transferrin saturation, serum ferritin and phlebotomy-mobilizable iron (r= 0.07, 0.207 and −0.005 respectively). In patients with mobilizable iron greater than four grams who were not C282Y homozygous there was weak correlation between the MCV versus serum transferrin saturation and serum ferritin (r= 0.39 and 0.37 respectively) and no significant correlation versus phlebotomy-mobilizable iron (r= 0.04). Conclusion: Our study confirms the presence of elevated MCV levels in patients with Hereditary Hemochromatosis. The mean MCV was high in both C282Y homozygous individuals as well as those with elevated levels of body iron (>4 g) who were not homozygous for the C282Y HFE mutation. For the most part, the elevated MCV did not correlate with measures of body iron stores although there was a weak correlation with serum transferrin saturation and serum ferritin among iron-loaded individuals who were not homozygous for C282Y. Further studies of the factors that influence MCV in these patients may provide insights into the derangements of iron utilization that may occur in iron overload syndromes.

scholarly journals Abnormalities in Iron Metabolism in Multiple Sclerosis

1989 ◽  
Vol 16 (2) ◽  
pp. 184-186 ◽  
Author(s):  
Leslie S. Valberg ◽  
Peter R. Flanagan ◽  
Ann Kertesz ◽  
George C. Ebers
Keyword(s):  
Multiple Sclerosis ◽  
Serum Ferritin ◽  
Iron Metabolism ◽  
Transferrin Saturation ◽  
High Serum ◽  
Red Cell ◽  
Hemochromatosis Gene ◽  
Severity Of The Disease ◽  
Bilateral Assistance ◽  
Relationship Of

ABSTRACT:High iron concentrations have been reported in the brains of multiple sclerosis victims. To determine if there are abnormalities in general iron metabolism indicative of iron overload in MS, measurements of transferrin saturation, serum ferritin and red cell ferritin in 31 female and 18 male patients were compared to the results in 49 age- and sex-matched healthy controls. Compared to controls, mean serum ferritin in MS was high, whereas transferrin saturation and red cell ferritin were similar. High values in one or more individual test results were observed in eleven MS patients. They were prevalent in patients who required bilateral assistance to walk or were confined to a chair, and appeared to be related to the severity of the disease. An investigation was made into the relationship of the high serum ferritin values in MS to the HLA-A3 histocompatibility antigen, a marker of the hemochromatosis gene which is prevalent in MS. A statistically significant interaction was not found between serum ferritin and the presence of HLA-A3.

scholarly journals Relationship of maternal and neonatal iron status

2016 ◽  
Vol 10 (4) ◽  
Author(s):  
Iqbal Nazar ◽  
Muhammad Tayyib ◽  
Tahira Tasneem ◽  
Muhammad Farooq ◽  
Ikram Din Ujjan
Keyword(s):  
Pregnant Women ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Iron Status ◽  
Hemoglobin Level ◽  
Group A ◽  
Level Of Significance ◽  
Group B ◽  
Relationship Of ◽  
Level Group

A total of 80 full term pregnant women were selected and were divided into two groups on the basis of hemoglobin level. Group A included 40 pregnant women having Hb level more than 11.0 g/dl. Group A, included neonates born to group A mothers. Group B included 40 pregnant women having Hb < 11.0 g/dl and B, included their respective neonates. Serum iron, serum TIBC and serum ferritin were done by commercially available kits. Results obtained were analyzed by using students `t` test and level of significance was done. Serum iron and serum ferritin w as reduced in mothers of group B and their respective neonates while serum TIBC was higher in mothers and neonates of group B.

scholarly journals Prevalence and risk factors of anemia in under five-year-old children in children’s hospital

2018 ◽  
Vol 5 (2) ◽  
pp. 499
Author(s):  
Kanchana . ◽  
Madhusudan Sr. ◽  
Sam Ahuja ◽  
Niranjan Nagaraj
Keyword(s):  
Risk Factors ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Serum Ferritin ◽  
Transferrin Saturation ◽  
Public Health Problem ◽  
Developed Countries ◽  
Hemoglobin Level ◽  
Deficiency Anemia ◽  
Global Public Health

Background: Anemia is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. This study is conducted to assess the proportion of children, aged between 6 months to 5 years having anemia and risk factors of iron deficiency anemia among selected children with anemia. Methods: The present cross-sectional study was conducted in 500 children between the age of 6 months to 5 years, who were admitted (in patients) to the Department of Pediatrics of Dr. BR Ambedkar Medical College, Bangalore, were selected and screened for anemia by hemoglobin estimation. This study was carried out from November 2012 to April 2014. Among those children with hemoglobin <11 g/dl, were screened for iron deficiency anemia (Serum ferritin estimation is done). Among these 500 children, 100 children with a hemoglobin level of 11 gm/dl and serum ferritin <12 μg/L were taken up for detailed study. All the collected data was tabulated and statically analysed by using appropriate methods Results: 77.8% of screened children were found to have anemia. In studied children 38% had mild anemia, 54% had moderate anemia and 8% had severe anemia. Male outnumbered than female in the ratio of 1.17:1. More than 50% presented with acute gastroenteritis.79% of anemic children had malnutrition. 24% of anemic children were low birth weight. Dimorphic anemia was common in 6months to 5 years age group. Mean hemoglobin level was 9.26. Mean ferritin, mean serum iron, TIBC, transferrin saturation was 7.23 μg/l, 52.60μg/dl, 346.89mg/dl and 16.31% respectively Conclusions: The diet deficient in iron and other essential nutrients is the single most important cause of anemia in children of this age Diarrhea was the chief associated symptom in more than half the cases studied. Hence it is essential to make provision for safe drinking water and to improve sanitary facilities periodic deworming measure is advised, to reduce parasitic infestation which also contributes to the development of anemia.

Analysis of Maximum Expiratory Flow Volume Curves Using Canonical Correlation Analysis

1985 ◽  
Vol 24 (02) ◽  
pp. 91-100 ◽  
Author(s):  
W. van Pelt ◽  
Ph. H. Quanjer ◽  
M. E. Wise ◽  
E. van der Burg ◽  
R. van der Lende
Keyword(s):  
Correlation Analysis ◽  
Canonical Correlation Analysis ◽  
Canonical Correlation ◽  
Flow Volume ◽  
Non Linear ◽  
Maximum Expiratory Flow ◽  
Expiratory Flow ◽  
Relationship Of ◽  
The Relationship ◽  
Age And Sex

SummaryAs part of a population study on chronic lung disease in the Netherlands, an investigation is made of the relationship of both age and sex with indices describing the maximum expiratory flow-volume (MEFV) curve. To determine the relationship, non-linear canonical correlation was used as realized in the computer program CANALS, a combination of ordinary canonical correlation analysis (CCA) and non-linear transformations of the variables. This method enhances the generality of the relationship to be found and has the advantage of showing the relative importance of categories or ranges within a variable with respect to that relationship. The above is exemplified by describing the relationship of age and sex with variables concerning respiratory symptoms and smoking habits. The analysis of age and sex with MEFV curve indices shows that non-linear canonical correlation analysis is an efficient tool in analysing size and shape of the MEFV curve and can be used to derive parameters concerning the whole curve.

Factors influencing the structure of the Russian companies' capital

2020 ◽  
Vol 26 (7) ◽  
pp. 1647-1660
Author(s):  
O.N. Likhacheva ◽  
A.S. Belikevich
Keyword(s):  
Correlation Analysis ◽  
Capital Structure ◽  
Systems Approach ◽  
Empirical Studies ◽  
Factors Influencing ◽  
Oil Contracts ◽  
Economic Landscape ◽  
Relationship Of ◽  
Trade Wars ◽  
The Capital Structure

Subject. In the uncertain market environment, the optimal structure of capital is getting more important because it influences the competitiveness of a firm, its financial sustainability and solvency and, consequently, a success. Herein we dwell upon the hypothesis presuming the existence of capital structure determinants. Objectives. We review empirical studies on the subject, analyze determinants of the Russian companies’ capital structure. Methods. The study is based on the systems approach and methods of statistical analysis. Results. It is necessary to monitor how capital is shaped and formed. We investigated proceedings on factors influencing the capital structure and discovered relevant hypotheses, carrying out the correlation analysis of such factors. Conclusions and Relevance. It is especially important to examine factors influencing the capital structure, and find the appropriate format for the economy struggling through the crisis. The coronavirus pandemic unavoidably reshapes the global economic landscape, which has already been under the pressure of deglobalization processes (trade wars, repudiation of oil contracts). The correlation analysis did not reveal any relationship of the variables in question (the company’s age, ROE, ROA, MOEX, key rate, GDP, PPI) and the capital structure. Further research should be devoted to other factors and consider the unreasonableness and psychological background of managers’ behavior who make decisions concerning the capital structure.

scholarly journals Relationship of Hemoglobin Level and Plasma Coproporphyrin‐I Concentrations as an Endogenous Probe for Phenotyping OATP1B

2021 ◽  
Author(s):  
Yosuke Suzuki ◽  
Yuri Sasamoto ◽  
Teruhide Koyama ◽  
Chisato Yoshijima ◽  
Ayako Oda ◽  
...  
Keyword(s):  
Hemoglobin Level ◽  
Relationship Of ◽  
Coproporphyrin I

scholarly journals Heat, Hills and the High Season: A Model-Based Comparative Analysis of Spatio-Temporal Factors Affecting Shared Bicycle Use in Three Southern European Islands

2021 ◽  
Vol 13 (6) ◽  
pp. 3274
Author(s):  
Suzanne Maas ◽  
Paraskevas Nikolaou ◽  
Maria Attard ◽  
Loukas Dimitriou
Keyword(s):  
Correlation Analysis ◽  
Mixed Models ◽  
Linear Mixed Models ◽  
Positive Association ◽  
Sustainable Mobility ◽  
Weather Factors ◽  
Gran Canaria ◽  
Bivariate Correlation ◽  
Temporal Factors

Bicycle sharing systems (BSSs) have been implemented in cities worldwide in an attempt to promote cycling. Despite exhibiting characteristics considered to be barriers to cycling, such as hot summers, hilliness and car-oriented infrastructure, Southern European island cities and tourist destinations Limassol (Cyprus), Las Palmas de Gran Canaria (Canary Islands, Spain) and the Valletta conurbation (Malta) are all experiencing the implementation of BSSs and policies to promote cycling. In this study, a year of trip data and secondary datasets are used to analyze dock-based BSS usage in the three case-study cities. How land use, socio-economic, network and temporal factors influence BSS use at station locations, both as an origin and as a destination, was examined using bivariate correlation analysis and through the development of linear mixed models for each case study. Bivariate correlations showed significant positive associations with the number of cafes and restaurants, vicinity to the beach or promenade and the percentage of foreign population at the BSS station locations in all cities. A positive relation with cycling infrastructure was evident in Limassol and Las Palmas de Gran Canaria, but not in Malta, as no cycling infrastructure is present in the island’s conurbation, where the BSS is primarily operational. Elevation had a negative association with BSS use in all three cities. In Limassol and Malta, where seasonality in weather patterns is strongest, a negative effect of rainfall and a positive effect of higher temperature were observed. Although there was a positive association between BSS use and the number of visiting tourists in Limassol and Malta, this is predominantly explained through the multi-collinearity with weather factors rather than by intensive use of the BSS by tourists. The linear mixed models showed more fine-grained results and explained differences in BSS use at stations, including differences for station use as an origin and as a destination. The insights from the correlation analysis and linear mixed models can be used to inform policies promoting cycling and BSS use and support sustainable mobility policies in the case-study cities and cities with similar characteristics.

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