scholarly journals Relationship of Hemoglobin Level and Plasma Coproporphyrin‐I Concentrations as an Endogenous Probe for Phenotyping OATP1B

2021 ◽  
Author(s):  
Yosuke Suzuki ◽  
Yuri Sasamoto ◽  
Teruhide Koyama ◽  
Chisato Yoshijima ◽  
Ayako Oda ◽  
...  
Keyword(s):  
Hemoglobin Level ◽  
Relationship Of ◽  
Coproporphyrin I

scholarly journals Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements amongHFEC282Y Homozygotes

2015 ◽  
Vol 2015 ◽  
pp. 1-9
Author(s):  
Seyed Ali Mousavi ◽  
Faiza Mahmood ◽  
Astrid Aandahl ◽  
Teresa Risopatron Knutsen ◽  
Abid Hussain Llohn
Keyword(s):  
Correlation Analysis ◽  
Serum Ferritin ◽  
Transferrin Saturation ◽  
Hemoglobin Level ◽  
Iron Depletion ◽  
Bivariate Correlation ◽  
Treatment Characteristics ◽  
Relationship Of ◽  
Baseline Hemoglobin

Objectives. We aimed to examine whether baseline hemoglobin levels in C282Y-homozygous patients are related to the degree of serum ferritin (SF) elevation and whether patients with different baseline hemoglobin have different phlebotomy requirements.Methods. A total of 196 patients (124 males and 72 females) who had undergone therapeutic phlebotomy and had SF and both pre- and posttreatment hemoglobin values were included in the study.Results. Bivariate correlation analysis suggested that baseline SF explains approximately 6 to 7% of the variation in baseline hemoglobin. The results also showed that males who had higher (≥150 g/L) baseline hemoglobin levels had a significantly greater reduction in their posttreatment hemoglobin despite requiring fewer phlebotomies to achieve iron depletion than those who had lower (<150 g/L) baseline hemoglobin, regardless of whether baseline SF was below or above 1000 µg/L. There were no significant differences between hemoglobin subgroups regarding baseline and treatment characteristics, except for transferrin saturation between male subgroups with SF above 1000 µg/L. Similar differences were observed when females with higher (≥138 g/L) baseline hemoglobin were compared with those with lower (<138 g/L) baseline hemoglobin.Conclusion. Dividing C282Y-homozygous patients into just two subgroups according to the degree of baseline SF elevation may obscure important subgroup variations.

scholarly journals ASUPAN ZAT BESI, ASAM FOLAT, DAN SENG TERHADAP KADAR HEMOGLOBIN PADA IBU HAMIL DI PUSKESMAS PACCERAKKANG KECAMATAN BIRINGAKANAYA KOTA

2019 ◽  
Vol 26 (2) ◽  
pp. 165
Author(s):  
Abdullah Tamrin
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Hemoglobin Level ◽  
Deficiency Anemia ◽  
P Value ◽  
Iron Intake ◽  
Zinc Intake ◽  
Acid Intake ◽  
Relationship Of ◽  
The Relationship

ABSTRACTAnemia is a health problem that is often found in developing countries including indonesia. Iron deficiency anemia often occurs in pregnant women. Other micronutrient deficiencies such as folic and zinc and copper also play a role in the occurrence of anemia in pregnancy. The purpose of the study was to determine the relationship of iron determine the relationship of iron, folid acid, and zinc intake to hemoglobin levels in pregnant women in Paccerakkang health center Biringkanaya district Makassar city. This type of research was observational with a cross sectional stud design. The sample in this study were pregnant women who had normal hemoglobin levels of 15 people and abnormal hemoglobin levels of 17 people who examined at Paccerakkang health center Biringkanaya district, Makassar city. Iron intake, folid acid and zinc were obtained by using the 24 hour recall method and the respondents identity data was obtained from direct interviews using a questionnaire while the hemoglobin data was obtained through hemoglobin examination at Paccerakkang health center Biringkanaya district, Makassar city. The results of the analysis between the relationship between iron intake and hemoglobin levels with p value = 0,010 which means there is a relationship between iron and hemoglobin level.  The results of the analysis between the relationship of folic acid intake with hemoglobin levels with p value=0,020 which means there is a relationship between folid acid intake and hemoglobin level. The results of the analysis between the relationship between zinc intake and hemoglobin level were p=0,015 which means that there is a relationship between zinc intake and hemoglobin level

The basicities of the nitrogen atoms in the porphyrin nucleus; their dependence on some substituents of the tetrapyrrolic ring

1952 ◽  
Vol 213 (1114) ◽  
pp. 307-326 ◽  
Keyword(s):  
Aqueous Solution ◽  
Dissociation Constants ◽  
Free Acid ◽  
Dimethyl Ester ◽  
Ultra Violet ◽  
Spectrophotometric Titration ◽  
Ring Nitrogen ◽  
Two Stages ◽  
Relationship Of ◽  
Coproporphyrin I

Porphyrins have been shown to be stronger bases than previously supposed, two protons being added in two stages to the nitrogen atoms in the conjugated tetrapyrrolic ring as the pH of an aqueous solution is decreased from pH 12 to 0. The existence of mono-cations of certain porphyrins in aqueous solution with characteristic visible and ultra-violet absorption spectra has been established, p K' a values for the two more basic ring nitrogen atoms of coproporphyrin I, deuteroporphyrin IX dimethyl ester disulphonic acid, N -methyl coproporphyrin I free acid and its tetramethyl ester have been determined by spectrophotometric titration in various buffer systems. Information on the basicity of uroporphyrin I and mesoporphyrin IX is also included. N -Methyl coproporphyrin has been prepared. The relationship of these p K' a values to the thermodynamic dissociation constants is discussed. Comparison of the p K' values obtained has led to certain conclusions regarding the effect on its basicity of some substituents of the tetrapyrrolic ring, and possible structures for the free bases and cations are considered in the light of these findings.

scholarly journals HYPERPROLACTINEMIA AND ANEMIA IN HEMODIALYSIS PATIENTS

2020 ◽  
Vol 25 ◽  
pp. 32-34
Author(s):  
Olena Loboda
Keyword(s):  
Cohort Study ◽  
Negative Correlation ◽  
Prospective Cohort ◽  
Cardiovascular Events ◽  
Hemodialysis Patients ◽  
Albumin Level ◽  
Hemoglobin Level ◽  
Serum Prolactin ◽  
Relationship Of ◽  
The Relationship

Aims: To determine the relationship of prolactin (PL) levels with the frequency of anemia and the level of cardiovascular events in patients with CKD VD stage.Material and methods: A prospective cohort study included 55 patients with CKD VD stage with anemia. Serum prolactin levels were determined in all patients.Results and discussion: 24 patients (44%) had normal levels of PL, and 31 (56%) patients had elevated levels of PL. It was determined that PL had a negative correlation with hemoglobin level (r = -0.42; p = 0.01), as well as a negative correlation with albumin level (r = -0.38; p = 0.02). The frequency of cardiovascular events after 12 months. In patients with elevated levels of PL was significantly higher than in patients with normal levels of PL: 17 events (55%) vs 4 events (17%) (χ2 8.4, p = 0.004).Conclusions: The prevalence of hyperprolactinemia in our study was 56%. Elevated levels of PL are associated with lower levels of hemoglobin, lower levels of albumin and an increased frequency of cardiovascular events.

scholarly journals Relationship of maternal and neonatal iron status

2016 ◽  
Vol 10 (4) ◽  
Author(s):  
Iqbal Nazar ◽  
Muhammad Tayyib ◽  
Tahira Tasneem ◽  
Muhammad Farooq ◽  
Ikram Din Ujjan
Keyword(s):  
Pregnant Women ◽  
Serum Ferritin ◽  
Serum Iron ◽  
Iron Status ◽  
Hemoglobin Level ◽  
Group A ◽  
Level Of Significance ◽  
Group B ◽  
Relationship Of ◽  
Level Group

A total of 80 full term pregnant women were selected and were divided into two groups on the basis of hemoglobin level. Group A included 40 pregnant women having Hb level more than 11.0 g/dl. Group A, included neonates born to group A mothers. Group B included 40 pregnant women having Hb < 11.0 g/dl and B, included their respective neonates. Serum iron, serum TIBC and serum ferritin were done by commercially available kits. Results obtained were analyzed by using students `t` test and level of significance was done. Serum iron and serum ferritin w as reduced in mothers of group B and their respective neonates while serum TIBC was higher in mothers and neonates of group B.

The basicities of the nitrogen atoms in the porphyrin nucleus; their dependence on some substituents of the tetrapyrrolic ring

1952 ◽  
Vol 140 (898) ◽  
pp. 143-144
Keyword(s):  
Aqueous Solution ◽  
Dissociation Constants ◽  
Free Acid ◽  
Dimethyl Ester ◽  
Ultra Violet ◽  
Ring Nitrogen ◽  
Disulphonic Acid ◽  
Two Stages ◽  
Relationship Of ◽  
Coproporphyrin I

Porphyrins have been shown to be stronger bases than previously supposed, two protons being added in two stages to the nitrogen atom s in the conjugated tetrapyrrolic ring as the pH of an aqueous solution is decreased from pH 12 to 0. The existence of mono-cations of certain porphyrins in aqueous solution with characteristic visible and ultra-violet absorption spectra has been established, p K ' a values for the two more basic ring nitrogen atoms of coproporphyrin I, deuteroporphyrin IX dimethyl ester disulphonic acid, N -methyl coproporphyrin I free acid and its tetram ethyl ester have been determ ined by spectrophotom etric titratio n in various buffer systems. Inform ation on the basicity of uroporphyrin I and mesoporphyrin IX is also included. N -Methyl coproporphyrin has been prepared. The relationship of these p K ' a values to the therm odynamic dissociation constants is discussed. Comparison of the p K ' values obtained has led to certain conclusions regarding the effect on its basicity of some substituents of the tetrapyrrolic ring, and possible structures for the free bases and cations are considered in the light of these findings.

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